Regulation of NOD signalling by IAPs and RIP kinases

IAP 和 RIP 激酶对 NOD 信号传导的调节

• 批准号: nhmrc : 1046986
• 负责人: Dr Andrew Webb
• 金额: $ 42.89万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-nod-signalling-rip-kinases/111894
• 关键词: Regulation; NOD; signalling; IAPs; RIP

Alterations in NOD signalling have been implicated in various human inflammatory diseases, particularly in Crohn’s disease and asthma. In this project we will identify new molecules that regulate NOD signalling and test the effect of drugs that inhibit known components of these pathways to determine their utility in treating inflammatory diseases.

NOD信号传导的改变与各种人类炎症性疾病有关，特别是克罗恩病和哮喘。在这个项目中，我们将确定调节NOD信号传导的新分子，并测试抑制这些途径的已知成分的药物的作用，以确定它们在治疗炎症性疾病中的效用。