HUMANIZED MOUSE MODELS FOR HIV THERAPEUTICS DEVELOPMENT

用于艾滋病毒治疗开发的人源化小鼠模型

• 批准号: 9915757
• 负责人: Cheryl Stoddart
• 金额: $ 104.22万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-06 至 2019-06-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9915757
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Animal Model; Contracts; Elements; HIV; HIV-1; Immunodeficient Mouse; Infection; Infectious Agent; Intervention; Modeling; National Institute of Allergy and Infectious Disease; Prevention; Program Development; Quality Control; Resources; Techniques; Technology; Testing; Therapeutic; Therapeutic Agents; Tissue Donors; Viral; drug development; drug discovery; efficacy evaluation; humanized mouse; improved; in vitro Model; in vivo; mouse model; novel; novel therapeutics; pathogen; preclinical evaluation; reconstitution; therapeutic development

NIAID supports a comprehensive portfolio of contract resources to discover and develop novel therapeutic agents for the prevention and treatment of infections caused by HIV-1, AIDS-associated opportunistic pathogens, and other infectious agents. Animal model resources constitute one element of this drug discovery and development program. NIAID initiates the preclinical evaluations of the efficacy and tolerability of novel HIV-1 therapeutics and selects the agents to be tested. The purpose of this contract is to provide small animal models that can be used to evaluate potential therapeutics for HIV-1 infection.

NIAID支持全面的合同资源组合，以发现和开发用于预防和治疗HIV-1、艾滋病相关机会病原体和其他传染性病原体引起的感染的新型治疗药物。动物模型 资源是这个药物发现和开发计划的一个要素。NIAID启动了对新型HIV-1治疗药物的疗效和耐受性的临床前评估，并选择了要测试的药物。本合同的目的是 提供可用于评估HIV-1感染的潜在治疗剂的小动物模型。