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HUMANIZED MOUSE MODELS FOR HIV THERAPEUTICS DEVELOPMENT

HUMANIZED MOUSE MODELS FOR HIV THERAPEUTICS DEVELOPMENT
用于艾滋病毒治疗开发的人源化小鼠模型
批准号：
9915757
负责人：
Cheryl Stoddart
金额：
$104.22万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
项目状态：
已结题
起止时间：
2019-03-06 至 2019-06-05
来源：
https://reporter.nih.gov/project-details/9915757
关键词：
AIDS/HIV problemAcquired Immunodeficiency SyndromeAnimal ModelContractsElementsHIVHIV-1Immunodeficient MouseInfectionInfectious AgentInterventionModelingNational Institute of Allergy and Infectious DiseasePreventionProgram DevelopmentQuality ControlResourcesTechniquesTechnologyTestingTherapeuticTherapeutic AgentsTissue DonorsViraldrug developmentdrug discoveryefficacy evaluationhumanized mouseimprovedin vitro Modelin vivomouse modelnovelnovel therapeuticspathogenpreclinical evaluationreconstitutiontherapeutic development

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中文摘要
翻译
NIAID支持全面的合同资源组合，以发现和开发用于预防和治疗HIV-1、艾滋病相关机会病原体和其他传染性病原体引起的感染的新型治疗药物。动物模型 资源是这个药物发现和开发计划的一个要素。NIAID启动了对新型HIV-1治疗药物的疗效和耐受性的临床前评估，并选择了要测试的药物。本合同的目的是 提供可用于评估HIV-1感染的潜在治疗剂的小动物模型。
英文摘要
NIAID supports a comprehensive portfolio of contract resources to discover and develop novel therapeutic agents for the prevention and treatment of infections caused by HIV-1, AIDS-associated opportunistic pathogens, and other infectious agents. Animal model resources constitute one element of this drug discovery and development program. NIAID initiates the preclinical evaluations of the efficacy and tolerability of novel HIV-1 therapeutics and selects the agents to be tested. The purpose of this contract is to provide small animal models that can be used to evaluate potential therapeutics for HIV-1 infection.
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Single-chain antibodies to block HIV transcription and prevent reactivation from latently infected resting CD4+ T cells
Inhibition of heat shock protein 90 for sustained remission of HIV from persistent tissue reservoirs
Heat shock protein 90 and HIV persistence
Heat shock protein 90 and HIV persistence
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