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IGF::OT::IGF "HUMANIZED MOUSE MODELS FOR HIV THERAPEUTICS DEVELOPMENT"

IGF::OT::IGF "HUMANIZED MOUSE MODELS FOR HIV THERAPEUTICS DEVELOPMENT"
IGF::OT::IGF“用于艾滋病治疗开发的人性化小鼠模型”
批准号：
9004371
负责人：
Cheryl Stoddart
金额：
$199.76万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
项目状态：
已结题
起止时间：
2013-12-06 至 2015-12-05
来源：
https://reporter.nih.gov/project-details/9004371
关键词：
Animal ModelClinical ResearchComplementContractsDataDrug EvaluationHIVIn VitroNational Institute of Allergy and Infectious DiseasePharmaceutical PreparationsPhasePrevention strategyProcessResearch PersonnelResearch SupportResourcesTherapeuticTimeTranslationsdrug discoveryin vitro activityin vivomouse modelnonhuman primateprogramstherapeutic developmenttool development

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中文摘要
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英文摘要
This initiative will support NIAID DAIDS drug discovery and evaluation programs by providing a contract to evaluate potential HIV therapeutics in small animal models. The proposed mouse models provide a bridge from in vitro studies to more costly non-human primate studies and early-phase clinical studies.
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Single-chain antibodies to block HIV transcription and prevent reactivation from latently infected resting CD4+ T cells
Inhibition of heat shock protein 90 for sustained remission of HIV from persistent tissue reservoirs
HUMANIZED MOUSE MODELS FOR HIV THERAPEUTICS DEVELOPMENT
Heat shock protein 90 and HIV persistence
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