A MULTIPOTENTIAL MITIGATION AGENT FOR GASTROINTESTINAL SYNDROME

为了获得许可，并根据FDA的动物规则，承包商将开发环状成纤维细胞生长因子-肽(FGF-P)，这是一种建议的成纤维细胞生长因子-2的生物改良剂，作为辐射诱导的胃肠道毒性的缓释剂。成纤维细胞生长因子-P通过多种机制发挥作用，包括减少细胞损失和促进小肠粘膜的增殖，通过减少细菌移位来改善肠道屏障功能，以及通过诱导粒细胞集落刺激因子(G-CSF)来支持骨髓。

The Contractor, in pursuit of licensure and in accordance with the FDA Animal Rule, will develop circular fibroblast growth factor-peptide (FGF-P), a proposed bio-better of FgF-2, as a mitigation agent for radiation-induced GI toxicity. FGF-P acts through a variety of mechanisms, including decreased cell loss and improved proliferation of small bowel mucosa, improved gut barrier function with reduced bacterial translocation, and support of bone marrow with induction of granulocyte-colony stimulating factor (G-CSF).