HIGH THROUGHPUT BIOMARKER-BASED BIODOSIMETRY

基于高通量生物标志物的生物剂量测定

• 批准号: 9915374
• 负责人: GEORGE SIGAL
• 金额: $ 73.07万
• 依托单位: MESO SCALE DIAGNOSTICS, LLC
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-15 至 2020-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9915374
• 关键词: Algorithms; Biological Assay; Biological Markers; Blood; Data; Devices; Emergency Situation; Goals; Immunoassay; Nuclear Accidents; Nuclear Radiology; Patients; Performance; Plasma; Population; Radiation; Sampling; Testing; Triage; Validation; base; biodosimetry; biomarker panel; mass casualty; programs; radiation absorbed dose

The goal of the program is to develop a high throughput biodosimetry test suitable for use in mass casualty situations following a radiological/nuclear incident. The device, the UHT Biodosimetry Test, will quantitate six blood biomarkers in patient plasma samples using multiplexed immunoassays and apply a multi-parameter algorithm to estimate absorbed radiation dose. The radiation markers have been developed and tested during MSD’s on-going biodosimetry program to develop a triage test

该计划的目标是开发一种高通量生物剂量测定测试，适用于放射性/核事件后的大规模伤亡情况。该设备名为 UHT 生物剂量测试，将使用多重免疫测定法对患者血浆样本中的六种血液生物标志物进行定量，并应用多参数算法来估计吸收的辐射剂量。辐射标记物是在默沙东正在进行的生物剂量测定计划中开发和测试的，以开发分类测试