Scientific Information Management and Literature-Based Evaluations for the National Toxicology Program (NTP) – Support for the conduct of Systematic Reviews

国家毒理学规划对文献进行系统审查，以根据有关人类接触的信息，评估药剂、物质、混合物或接触情景对人类健康的潜在不利影响。这些评论的发现通常集中在癌症或非癌症效应上，并以专著的形式发表。这些审查主要由DNTP健康评估和翻译办公室（OHAT）和致癌物报告（ORoC）进行。ORoC准备了国会授权的致癌物报告（RoC），其中列出了对居住在美国的人构成癌症危害的物质，以及与报告中潜在新清单物质的癌症危害评估相关的文件。目前正在对氟化物、空气污染、沙林、炎症/动脉粥样硬化、夜间灯光/轮班、熟肉、多环芳烃、卤乙酸和幽门螺杆菌进行系统审查。

The NTP performs systematic reviews of literature to assess the potential for adverse effects on human health by agents, substances, mixtures, or exposure scenarios, based on information about human exposure. The findings of these reviews generally focused on either cancer or non-cancer effects and published as monographs. These reviews are conducted primarily by the DNTP Offices of Health Assessment and Translation (OHAT) and the Report on Carcinogens (ORoC). The ORoC prepares the congressionally mandated Report on Carcinogens (RoC), which lists substances that pose a cancer hazard for people living in the United States, and documents related to the cancer hazard evaluation of substances as potential new listings in the report. Systematic reviews are in progress for fluoride, air pollution, Sarin, inflammation/atherosclerosis, light at night/shiftwork, cooked meat, polycyclic aromatic hydrocarbons, haloacetic acids, and H. pylori. Keywords: Systematic review, toxicology, epidemiology, exposure, cancer, non-cancer effects