Scientific Information Management and Literature-Based Evaluations for the National Toxicology Program (NTP) – Support for the DNTP Office of Health Assessment and Translation

一些支持dNTP健康评估和转换办公室(OHAT)的项目已经执行或正在进行中。OHAT为公众以及健康研究和监管机构提供环境健康资源。OHAT进行科学评估，重点是了解试剂、物质、混合物或暴露环境对人类健康的潜在不利影响。根据目前已知的人类暴露水平，这些评估可以得出NTP关于这些物质是否可能对人类健康造成担忧的结论。OHAT还组织研讨会或科学现状评估，以解决环境健康科学中的其他重要问题。这些项目涉及科学和技术专长以及承包商的支持，以汇编、审查和分析来自科学文献和其他来源的信息和数据，这些信息和数据涉及环境物质的影响和可能影响公众健康的其他问题。 关键词：系统综述、毒理学、流行病学、暴露、癌症、非癌症影响

A number of projects to support the DNTP Office of Health Assessment and Translation (OHAT) have been performed or are in progress. OHAT serves as an environmental health resource to the public as well as health research and regulatory agencies. OHAT conducts scientific assessments focused on understanding the potential for adverse effects on human health by agents, substances, mixtures, or exposure circumstances. These evaluations can lead to NTP conclusions on whether these substances may be a human health concern based upon what is known about current human exposure levels. OHAT also organizes workshops or state-of-the-science evaluations to address other issues of importance in environmental health sciences. These projects involve scientific and technical expertise and support from the contractor to compile, review, and analyze information and data from the scientific literature and other sources regarding the effects of environmental substances and other issues that may impact public health. Keywords: Systematic review, toxicology, epidemiology, exposure, cancer, non-cancer effects