Scientific Information Management and Literature-Based Evaluations for the National Toxicology Program (NTP) – Support for the DNTP Office of Health Assessment and Translation

一些支持DNTP健康评估和翻译办公室（OHAT）的项目已经完成或正在进行中。OHAT是公众以及卫生研究和管理机构的环境卫生资源。OHAT进行科学评估，重点是了解制剂、物质、混合物或接触环境对人类健康的潜在不利影响。这些评价可根据目前已知的人类接触水平得出NTP关于这些物质是否可能对人类健康造成影响的结论。OHAT还组织研讨会或科学现状评估，以解决环境卫生科学中的其他重要问题。这些项目需要承包者提供科学和技术专门知识和支持，以汇编、审查和分析来自科学文献和其他来源的关于环境物质的影响和可能影响公众健康的其他问题的信息和数据。 关键词：系统综述、毒理学、流行病学、暴露、癌症、非癌症效应

A number of projects to support the DNTP Office of Health Assessment and Translation (OHAT) have been performed or are in progress. OHAT serves as an environmental health resource to the public as well as health research and regulatory agencies. OHAT conducts scientific assessments focused on understanding the potential for adverse effects on human health by agents, substances, mixtures, or exposure circumstances. These evaluations can lead to NTP conclusions on whether these substances may be a human health concern based upon what is known about current human exposure levels. OHAT also organizes workshops or state-of-the-science evaluations to address other issues of importance in environmental health sciences. These projects involve scientific and technical expertise and support from the contractor to compile, review, and analyze information and data from the scientific literature and other sources regarding the effects of environmental substances and other issues that may impact public health. Keywords: Systematic review, toxicology, epidemiology, exposure, cancer, non-cancer effects