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中文摘要
翻译
食物过敏研究正在迅速发展,越来越多的多学科,因为全球意识 这种复杂的、多因素的、威胁生命的疾病正在加速。有史以来第一个III期试验 最近已经完成了治疗,像其他过敏性疾病一样,生物制剂 在未来几年内重塑临床治疗方法的潜力。 然而,关于饮食抗原免疫机制的非常基本的问题, 健康和疾病问题仍然没有得到解决,在某些情况下, 系统地处理。更好地理解机制,如先天和适应性 免疫细胞与神经感觉通路相互作用,以感知饮食并调节消化和 免疫系统将很可能导致新的更合理和有效的预防策略 和治疗。更好地理解Th2免疫在神经发育中的作用, 肿瘤学可能为安全应用快速出现的潜在 食物过敏、特应性皮炎、哮喘等问题的转化生物制剂 和其他过敏性疾病。2020年食物过敏戈登会议的总体目标是 提高食物过敏研究的质量和数量。我们致力于吸引顶级 研究人员在该领域,并充分整合学员,早期职业调查员,特别是 妇女和少数民族研究人员,以更好地反映并最终增加真正的多样性, 这一新兴领域的影响力越来越大。
英文摘要
Food allergy research is rapidly evolving and increasingly multidisciplinary, as global awareness of this complex, multifactorial, life-threatening disease accelerates. The first ever phase III trials of therapeutics have recently been completed, and like other allergic disease, biologics have the potential to reshape treatment approaches in the clinic over the coming next few years. However, very fundamental questions about the mechanisms of immunity to dietary antigens in health and disease remain unanswered and in some cases are just beginning to be systematically addressed. Better understanding mechanisms such as how innate and adaptive immune cells interact with neurosensory pathways to sense diet and regulate the digestive and immune systems will very likely lead to new more rational and effective prevention strategies and treatments. Better understanding the role of Th2 immunity in neurodevelopment and oncology may provide important insights for safe application of rapidly emerging and potentially transformational biologics to the problems of food allergy as well as atopic dermatitis, asthma and other allergic diseases. The overall aim for the 2020 Food Allergy Gordon Conference is to enhance the quality and quantity of food allergy research. We are committed to attracting top researchers in the field, and fully integrating trainees, early career investigators, and especially women and minority researchers, to better reflect and ultimately increase the true diversity of this emerging field of high and increasing impact.
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Immune progression and plasticity in relation to child age
  • 批准号:
    10416402
  • 项目类别:
  • 资助金额:
    $23.5万
  • 财政年份:
    2017
  • 负责人:
    WAYNE G SHREFFLER
  • 依托单位:
Immune progression and plasticity in relation to child age
  • 批准号:
    9308334
  • 项目类别:
  • 资助金额:
    $23.5万
  • 财政年份:
    2017
  • 负责人:
    WAYNE G SHREFFLER
  • 依托单位:
Immune progression and plasticity in relation to child age
  • 批准号:
    10579324
  • 项目类别:
  • 资助金额:
    $23.5万
  • 财政年份:
    2017
  • 负责人:
    WAYNE G SHREFFLER
  • 依托单位:
Regulatory and effector T cells in oral immunotherapy for food allergy
  • 批准号:
    8196488
  • 项目类别:
  • 资助金额:
    $35.13万
  • 财政年份:
    2011
  • 负责人:
    WAYNE G SHREFFLER
  • 依托单位:
海外基金