Defining the Relationships of Retinal Microcirculation with Glaucoma, Systemic Disease, and Ocular Anatomic Factors in African Americans

定义非裔美国人视网膜微循环与青光眼、全身性疾病和眼部解剖因素的关系

• 批准号: 9915923
• 负责人: Grace Marie Richter
• 金额: $ 22.36万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9915923
• 关键词: Adrenergic beta-Antagonists; Affect; African American; Age; Anatomy; Angiography; Angiotensin Receptor; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Area; Axon; Biostatistical Methods; Blindness; Blood; Blood Pressure; Blood Vessels; Blood capillaries; Blood flow; California; Clinical; Clinical Research; Cohort Studies; Color; Cornea; Data; Deltastab; Diabetes Mellitus; Diagnosis; Diastolic blood pressure; Disease; Disease Progression; Diuretics; Eye; Eye diseases; Foundations; Functional disorder; Future; Glaucoma; Glycosylated hemoglobin A; Goals; Hypertension; Image; Inner Plexiform Layer; Institutes; International; Intervention; Intervention Studies; Investigation; Longitudinal Studies; Measures; Mentors; Methods; Microcirculation; Myopia; Ophthalmology; Optical Coherence Tomography; Participant; Pathogenesis; Patients; Perfusion; Persons; Pharmaceutical Preparations; Physiologic Intraocular Pressure; Play; Population; Population Heterogeneity; Posterior eyeball segment structure; Primary Open Angle Glaucoma; Public Health; Reporting; Research; Research Proposals; Research Training; Retina; Retinal macula; Risk; Risk Factors; Role; Severities; Specialist; Staging; Structure; Subgroup; Systemic disease; Testing; Thick; Training; Training Programs; Universities; Vascular Diseases; Visual Fields; Work; arteriole; base; burden of illness; career development; epidemiology study; experience; field study; ganglion cell; high intraocular pressure; high resolution imaging; improved; insight; medical schools; meetings; optic nerve disorder; population based; prevent; professor; programs; research in practice; retinal nerve fiber layer; sex; vascular factor; vascular risk factor

PROJECT SUMMARY This K23 application is submitted by Grace Richter, MD, MPH, an Assistant Professor of Ophthalmology in the Glaucoma Division at the USC Roski Eye Institute at Keck School of Medicine of University of Southern California. The primary objectives of this K23 career development proposal are: 1) to provide an academic glaucoma specialist with the additional training and mentored research experience necessary to direct clinical studies independently; and 2) to perform cross-sectional research investigating the relationships of various retinal microcirculation perfusion parameters with primary open angle glaucoma (POAG), systemic vascular disease, and ocular anatomic factors in African Americans, who have a greater burden of POAG compared to other populations. Together, this will provide the foundation for me to establish an independent clinical research program using optical coherence tomography angiography (OCTA) to study factors that affect OBF and to elucidate how OBF affects glaucoma in an R01-sponsored longitudinal clinical study. While I already have a Masters in Public Health (MPH), this K23 training program will provide additional necessary training for this research. My training efforts will focus on four areas: (1) vessel quantification methods using OCTA; (2) methods in population-based and clinical cohort studies; (3) advanced biostatistical methods for epidemiology and clinical research; and (4) best research practices in diverse populations. In addition to formal coursework, training will be greatly enhanced by regular meetings with renowned mentors (Dr. Rohit Varma, Dr. Ruikang Wang, Dr. James Gauderman, and Dr. Roberta McKean-Cowdin), as well as participation in local and international meetings. This research proposal will utilize OCTA data collected on participants of the African American Eye Disease Study to define the relationships of 4 different measures of retinal perfusion with: (1) glaucoma, including both structural and functional measures; (2) systemic vascular diseases including diabetes and hypertension; and (3) ocular anatomic features including intraocular pressure, central corneal thickness, and axial myopia in glaucoma and non-glaucoma patients. These systemic and ocular factors are thought to be risk factors for glaucoma, but the underlying mechanisms are not well understood. Defining the relationships of these entities with retinal perfusion parameters will give us better insight into the pathogenesis of glaucoma and will generate improved hypotheses for glaucoma pathophysiology. This research will provide key data for subsequent longitudinal studies and generate refined hypotheses for possible interventional studies. Ultimately, it will lead to improved treatments that prevent blindness from glaucoma.

项目摘要 这个K23申请是由Grace Richter，医学博士，公共卫生硕士，眼科助理教授提交的。 南加州大学凯克医学院Roski眼科研究所青光眼科 加州。本K23职业发展计划的主要目标是：1）提供学术 青光眼专家，具有指导临床所需的额外培训和指导研究经验 独立研究; 2）进行横断面研究，调查各种 视网膜微循环灌注参数与原发性开角型青光眼（POAG），全身血管 非裔美国人的POAG负担更大， 其他人口。总之，这将为我建立一个独立的临床 使用光学相干断层扫描血管造影术（OCTA）研究影响OBF的因素的研究计划 并在R01赞助的纵向临床研究中阐明OBF如何影响青光眼。虽然我已经 有公共卫生硕士（MPH），这个K23培训计划将提供额外的必要培训， 这项研究。我的培训工作将集中在四个方面：（1）使用OCTA的血管量化方法;（2） 基于人群和临床队列研究的方法;（3）流行病学的先进生物统计方法 和临床研究;（4）在不同人群中的最佳研究实践。除了正式的课程外， 通过与知名导师（Rohit Varma博士、Ruikang博士）定期会面，培训将得到极大的加强 Wang，James Gauderman博士和Roberta McKean-Cowdin博士），以及参与当地和 国际会议。这项研究提案将利用OCTA收集的非洲参与者数据， 美国眼科疾病研究，以确定视网膜灌注的4种不同测量方法与以下各项的关系：（1） 青光眼，包括结构和功能测量;（2）全身性血管疾病，包括糖尿病 和高血压;和（3）眼部解剖学特征，包括眼内压，中央角膜厚度， 青光眼和非青光眼患者的轴性近视。这些全身和眼部因素被认为是 青光眼是青光眼的危险因素，但其潜在的机制还不清楚。定义 这些实体与视网膜灌注参数的关系将使我们更好地了解发病机制 并将产生青光眼病理生理学的改进假说。这项研究将提供 为后续纵向研究提供关键数据，并为可能的干预性研究产生精确的假设。 问题研究最终，它将导致预防青光眼失明的治疗方法的改进。