Malaria Epidemiology In Southeast Asia: Intra- and Inter-Country Dynamics

东南亚疟疾流行病学：国家内部和国家间动态

• 批准号: 9915850
• 负责人: Myat Phone Kyaw
• 金额: $ 70.06万
• 依托单位: UNIVERSITY OF SOUTH FLORIDA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9915850
• 关键词: Achievement; Address; Area; Artemisinins; China; Chloroquine; Country; Effectiveness; Epidemiology; Face; Falciparum Malaria; Foundations; Genetic; Genetic Variation; Genomics; Glucosephosphate Dehydrogenase Deficiency; Goals; High Prevalence; Human; Infection; International; Interruption; Intervention; Knowledge; Malaria; Measures; Methods; Migrant; Molecular; Monitor; Morbidity - disease rate; Multi-Drug Resistance; Myanmar; Nonmigrant; Parasites; Plasmodium vivax; Politics; Population; Population Heterogeneity; Prevalence; Primaquine; Public Health; Relapse; Research; Resistance; Risk Factors; Sentinel; Severities; Site; Social Behavior; Southeastern Asia; Technology; Testing; Thailand; Time; Travel; Treatment Failure; Treatment Protocols; Variant; Vivax Malaria; World Health Organization; effectiveness evaluation; innovation; malaria infection; malaria transmission; migration; molecular diagnostics; mortality; non-compliance; prevent; programs; resilience; side effect; southeast Asian; time use; tool; transmission process; treatment duration

PROJECT 1 SUMMARY Despite the recent global reduction in malaria morbidity and mortality, malaria in the Greater Mekong Subregion (GMS) of Southeast Asia remains one of the most important public health problems. While nations in this region are moving towards malaria elimination, they face a daunting array of challenges, including continuous transmission of malaria along the international borders, introduction and spread of multidrug resistant malaria parasites by human migrants from neighboring countries, and the persistent Plasmodium vivax malaria. Accordingly, we strategically select study sites at the international borders of China, Thailand and Myanmar, which vary significantly in malaria endemicity, to address these problems. The overarching objective of this project is to gain critical epidemiological information about factors contributing to the persistence of border malaria in the GMS so that more effective malaria control strategies can be developed. In this project, we aim to (1) conduct malaria surveillance and use highly sensitive molecular diagnostic tools to identify transmission hotspots and risk factors for malaria infection; (2) determine and monitor the impact of control programs and parasite introduction in the border regions on changes in parasite population diversity in space and time using population genomic and landscape genetic tools; and 3) evaluate the effectiveness of the chloroquine-primaquine treatment regimen as a radical cure of vivax malaria in border areas with high prevalence of glucose-6-phosphate dehydrogenase deficiency. This project lays important foundations for other projects of the ICEMR program, and will provide critical knowledge for developing and evaluating integrated malaria management strategies.

项目1概要 尽管最近全球疟疾发病率和死亡率有所下降， 东南亚次区域（GMS）仍然是最重要的公共卫生问题之一。虽然各国 在该地区，正在朝着消灭疟疾的目标迈进，但他们面临着一系列令人生畏的挑战，包括 疟疾沿着国际边界持续传播， 来自邻国的人类移民的耐药性疟疾寄生虫，以及持续存在的疟原虫 间日疟因此，我们战略性地选择了位于中国、泰国和泰国边境的研究中心， 在疟疾流行率方面差异很大的缅甸，为解决这些问题，总体 这一项目的目标是获得关于造成艾滋病的因素的重要流行病学信息， （c）确保大湄公河次区域边界疟疾的持续存在，以便制定更有效的疟疾控制战略。在 在这个项目中，我们的目标是（1）进行疟疾监测，并使用高度敏感的分子诊断工具， 确定疟疾感染的传播热点和风险因素;（2）确定和监测 控制程序和寄生虫引进在边境地区的寄生虫种群多样性的变化， 空间和时间使用人口基因组和景观遗传工具;和3）评估的有效性， 氯喹-伯氨喹方案治疗边境高疟区间日疟疗效观察 葡萄糖-6-磷酸脱氢酶缺乏症的患病率。该项目奠定了重要基础， ICEMR计划的其他项目，并将为开发和评估提供关键知识 疟疾综合管理战略。