A New Paradigm for Treating Functional Abdominal Pain Disorders in Children

工程摘要 John M.医学博士Hollier是一位委员会认证的儿科胃肠病学家，是贝勒学院的助理教授 寻求获得独立职业所需的基本技能和指导研究经验的医学博士 作为一名儿科临床研究人员利用健康技术。医学的许多方面都受到 药物依从性差，不明智的健康行为，以及难以获得医疗保健。候选人的 职业目标是通过利用电流的潜力来克服这些障碍（例如，移动的）和未来 技术作为工具来实现这些努力。功能性腹痛疾病（FAPD）影响高达 全世界20%的学龄儿童（和成人），并与显著的发病率和健康相关 护理费用。高达60%的FAPD儿童继续与成人有类似的情况。许多受影响 儿童患有焦虑和抑郁等社会心理困扰。最有效的治疗方法 对于大多数患有FAPD的儿童来说，治疗精神障碍（心理干预）仍然遥不可及。申请人 建议完善他的创新移动的应用程序（App）原型，旨在远程传输音频- 使用公认的技术对患有FAPD的儿科患者进行记录引导成像治疗（ARGIT App） 开发技术。具体目标：1）完善我们的ARGIT应用程序原型的设计，操作和GIT 通过使用定性访谈，通过患者、护理人员和专家利益相关者的反馈确定会议内容2） 进行一项双盲、随机对照试验，比较GIT与深呼吸练习（对照） 在患有FAPD的儿童中使用经过改进的ARGIT App超过8周，以评估引导成像的有效性 治疗和评估是否改变了心理社会困扰作为这种干预的结果随着时间的推移。第三章 通过以下方式评估受影响儿童及其照顾者对改进后的ARGIT应用程序的可接受性： 定性访谈。Hollier博士组建了一个由NIH资助的受人尊敬的导师组成的多学科团队 以及在移动的健康应用程序开发、临床试验 方法学、定性研究方法和健康行为改变专家。此外该 候选人将获得额外的技能和培训，通过教学课程，讲习班，指导 阅读和会议。通过这项赠款获得的科学培训将导致出版物，数据， 和经验，使候选人能够获得NIH的资金，并建立自己作为一个独立的 医学科学家

Project Abstract John M. Hollier, MD, a board-certified pediatric gastroenterologist, is an Assistant Professor at Baylor College of Medicine who seeks to obtain essential skills and mentored research experience for an independent career as a pediatric clinical researcher utilizing health technologies. Many aspects of medicine are affected by poor medication adherence, ill-advised health behaviors, and poor access to medical care. The candidate’s career goal is to conquer these barriers by harnessing the potential of current (e.g., mobile) and future technologies as tools to fulfill these endeavors. Functional abdominal pain disorders (FAPDs) affect up to 20% of school-age children (and adults) worldwide and are associated with significant morbidity and health care costs. Up to 60% of children with FAPDs go on to have similar conditions as adults. Many affected children suffer from psychosocial distress like anxiety and depression. The most effective treatment for these disorders (psychological interventions) remains out of reach for most children with FAPDs. The applicant proposes to refine his innovative mobile application (App) prototype designed to remotely deliver audio- recorded guided imagery therapy (ARGIT App) for pediatric patients with FAPDs using accepted technology development techniques. Specific Aims: 1) Refine our ARGIT App prototype’s design, operation, and GIT session content via patient, caregiver, and expert stakeholders’ feedback by using qualitative interviews 2) Conduct a double-blind, randomized controlled trial comparing GIT versus deep breathing exercises (control) utilizing the refined ARGIT App over 8 weeks in children with FAPDs to assess the efficacy of guided imagery therapy and evaluate whether psychosocial distress is altered as a result of this intervention over time. 3) Assess acceptability of the refined ARGIT App among affected children and their caregivers through qualitative interviews. Dr. Hollier has assembled a multidisciplinary team of esteemed NIH-funded mentors and collaborators with a diverse range of expertise in mobile health App development, clinical trial methodology, qualitative research methods, and health behavior change specialists. In addition, the candidate will acquire additional skills and training through didactic coursework, workshops, directed readings, and conferences. The scientific training obtained through this grant will lead to publications, data, and experience that will enable the candidate to secure NIH funding and establish himself as an independent physician scientist.