A New Paradigm for Treating Functional Abdominal Pain Disorders in Children

治疗儿童功能性腹痛疾病的新范例

• 批准号: 10584464
• 负责人: John M Hollier
• 金额: $ 18.39万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-18 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10584464
• 关键词: Abdominal Pain; Address; Adolescent; Adult; Affect; Aftercare; Anxiety; Behavioral; Biochemical; Board Certification; Caregivers; Caring; Child; Childhood; Clinical; Clinical Research; Clinical Trials; Cognitive Therapy; Control Groups; Data; Development; Disease; Distress; Double-Blind Method; Educational workshop; Elements; Face; Feedback; Focus Groups; Foundations; Frequencies; Funding; Future; Gastroenterologist; Goals; Grant; Guided imagery; Guidelines; Health Care Costs; Health Services Accessibility; Health Technology; Health behavior; Health behavior change; Intervention; Interview; Irritable Bowel Syndrome; Literature; Manuscripts; Medical; Medicine; Mental Depression; Mental Health; Mentors; Methodology; Mobile Health Application; Morbidity - disease rate; Mothers; Pain; Pain Disorder; Parents; Patients; Persons; Physicians; Provider; Publications; Qualitative Research; Quality of life; Randomized; Randomized, Controlled Trials; Recommendation; Research; Research Methodology; Research Personnel; School-Age Population; Scientist; Secure; Severities; Specialist; Structural defect; Target Populations; Technology; Testing; Theory of Change; Therapeutic; Time; Training; Treatment Efficacy; United States National Institutes of Health; Waiting Lists; assessment application; career; career development; chronic abdominal pain; clinical center; college; cost; cost effective; deep breathing exercises; design; effective therapy; efficacy evaluation; expectation; experience; health care service utilization; health related quality of life; improved; innovation; insight; medication compliance; mobile application; multidisciplinary; novel; operation; pain catastrophizing; pain symptom; participant interview; patient engagement; patient oriented; pediatric health outcomes; pediatric patients; preference; primary outcome; professor; prototype; psychologic; psychosocial; randomized, clinical trials; remote delivery; secondary outcome; skills; symposium; systemic barrier; technology development; technology/technique development; tool; treatment as usual; treatment comparison; treatment duration; trial comparing

John M. Hollier, MD, a board-certified pediatric gastroenterologist, is an Assistant Professor at Baylor College of Medicine who seeks to obtain essential skills and mentored research experience for an independent career as a pediatric clinical researcher utilizing health technologies. Many aspects of medicine are affected by poor medication adherence, ill-advised health behaviors, and poor access to medical care. The candidate’s career goal is to conquer these barriers by harnessing the potential of current (e.g., mobile) and future technologies as tools to fulfill these endeavors. Functional abdominal pain disorders (FAPDs) affect up to 20% of school-age children (and adults) worldwide and are associated with significant morbidity and health care costs. Up to 60% of children with FAPDs go on to have similar conditions as adults. Many affected children suffer from psychosocial distress like anxiety and depression. The most effective treatment for these disorders (psychological interventions) remains out of reach for most children with FAPDs. The applicant proposes to refine his innovative mobile application (App) prototype designed to remotely deliver audio-recorded guided imagery therapy (ARGIT App) for pediatric patients with FAPDs using accepted technology development techniques. Specific Aims: 1) Refine our ARGIT App prototype’s design, operation, and guided imagery therapy (GIT) session content via patient, caregiver, and expert stakeholders’ feedback by using qualitative interviews 2) Conduct a pragmatic, randomized, waitlist-controlled trial comparing treatment with GIT versus usual care in children with FAPDs to assess the ARGIT App’s efficacy and evaluate whether psychosocial distress is altered as a result of this intervention over time. 3) Assess acceptability of the refined ARGIT App among affected children and their caregivers through qualitative interviews. Dr. Hollier has assembled a multidisciplinary team of esteemed NIH-funded mentors and collaborators with a diverse range of expertise in mobile health App development, clinical trial methodology, qualitative research methods, and health behavior change specialists. In addition, the candidate will acquire additional skills and training through didactic coursework, workshops, directed readings, and conferences. The scientific training obtained through this grant will lead to publications, data, and experience that will enable the candidate to secure NIH funding and establish himself as an independent physician scientist.

John M.Hollier医学博士是一名获得董事会认证的儿科胃肠病专家，他是贝勒医学院的助理教授，他寻求获得基本技能和指导研究经验，以便利用健康技术作为儿科临床研究员进行独立的职业生涯。医学的许多方面都受到不良用药依从性、不明智的健康行为和难以获得医疗服务的影响。应聘者的职业目标是通过利用当前(例如移动)和未来技术的潜力来实现这些努力，从而克服这些障碍。功能性腹痛障碍(FAPD)影响着全世界高达20%的学龄儿童(和成人)，并与显著的发病率和医疗费用有关。高达60%的患有FAPDS的儿童继续患有与成人类似的疾病。许多受影响的儿童患有焦虑和抑郁等心理社会痛苦。这些疾病的最有效治疗(心理干预)对大多数FAPDS儿童来说仍然遥不可及。申请人建议改进他的创新移动应用程序(App)原型，旨在使用公认的技术开发技术为患有FAPD的儿童患者远程提供录音引导成像治疗(ARGIT App)。具体目标：1)通过定性访谈，通过患者、护理者和专家利益相关者的反馈，完善我们的ARGIT App原型的设计、操作和引导意象疗法(GIT)会话内容2)对患有FAPDS的儿童进行务实、随机、等待名单控制的试验，比较治疗与GIT治疗和常规护理，以评估ARGIT App的疗效，并评估随着时间的推移，这种干预是否会改变心理社会困境。3)通过定性访谈，评估改进的ARGIT App在受影响儿童及其照顾者中的可接受性。Hollier博士组建了一个由受人尊敬的NIH资助的导师和合作者组成的多学科团队，他们在移动健康应用程序开发、临床试验方法学、定性研究方法和健康行为改变专家方面拥有不同的专业知识。此外，候选人将通过教学课程、研讨会、定向阅读和会议获得额外的技能和培训。通过这笔拨款获得的科学培训将导致出版物、数据和经验，使候选人能够获得NIH的资金并确立自己作为一名独立的内科科学家的地位。