Integrative Training in the Neurocircuitry of Affective Disorders

 描述(申请人提供)：标题：情感障碍神经回路的综合培训拟议修订的机构国家研究服务奖培训计划将为基础和临床神经科学家提供技能和导师指导的经验，以推动他们进入跨学科研究生涯，旨在加深对大脑回路和情感的理解。我们要求为第一年的两个职位和随后的每一年四个职位提供资金。应用于理解精神病理学的大脑回路领域是一个迅速发展的领域，具有极大的潜力来帮助理解情感性精神疾病的原因路径和机制。抑郁症和应激神经调节中心(CNDS)与宾夕法尼亚大学(Penn)多个系、中心和研究所合作，准备推出这一基于已有的成像创新以及拟议的多学科导师小组提供的一系列相关专业知识的新型博士后奖学金。拟议的培训认识到，了解大脑电路病理学所需的工具需要培训，涉及精神病理学、人类神经成像方法学、统计学、工程学、神经科学、遗传学和具有相关成像的基本翻译模型，如光遗传学。该项目将由伊维特·谢林(Yvette Sheline)博士(抑郁症和压力的神经成像)指导。John Detre博士(功能神经成像的临床神经科学和方法开发)将担任副主任。宾夕法尼亚大学的许多研究人员也加入了他们的行列，他们在情感障碍的成像方面有着丰富的记录，其中包括一支走在新方法开发前沿的调查人员队伍；这些实验室中的许多将与受训人员一起设在一个新的设施中。使用神经科学模型将大脑回路方法用于精神病理学的研究是一种新的训练方法。鉴于佩雷尔曼医学院临床和基础系的神经影像研究人员之间已经建立的合作关系，以及他们与生物医学研究生研究计划的接口，项目导师提供了一个独特的多学科培训环境，在其中追求这一令人兴奋的新方法。该大学在神经成像和翻译神经科学领域的前沿作用提供了一个机会，帮助培养下一代年轻科学家，他们可以从核心心理、神经和翻译机制的角度探讨情感疾病中大脑回路异常的基本问题，这些机制可以告知和跨越精神病理学的传统界限，并导致更有效的治疗和确定新的预防目标。

 DESCRIPTION (provided by applicant):Title: Integrated Training in Neurocircuitry of Affective Disorders The proposed revised Institutional National Research Service Award Training Program will provide basic and clinical neuroscientists with the skills and mentor-guided experiences to propel them into an interdisciplinary research career designed to further the understanding of brain circuitry and affect. We request funds for two positions in Year 1 and four positions each subsequent year. The area of brain circuitry as applied to understanding psychopathology is a rapidly growing domain with great potential to inform the understanding of the causal pathways and mechanisms of affective mental illness. The Center for Neuromodulation in Depression and Stress (CNDS), in collaboration with multiple University of Pennsylvania (PENN) departments, centers and institutes is well poised to launch this novel post-doctoral fellowship based on established innovations in imaging, as well as the range of related expertise offered by the proposed multidisciplinary mentor group. The proposed training recognizes that the tools necessary to understand brain circuitry pathology require training across psychopathology, human neuroimaging methodology, statistics, engineering, neuroscience, genetics and basic translational models with associated imaging, such as optogenetics. The program will be guided by Dr. Yvette Sheline, (neuroimaging of depression and stress). Dr. John Detre (clinical neuroscience and methods development in functional neuroimaging) will be Associate Director. They are joined by numerous investigators at PENN with a rich track record of experience in imaging of affective disorders, including a cadre of investigators at the forefront of new methods development; many of these labs will be co-located, along with trainees, in a new facility. Research taking a brain circuit approach to psychopathology using a neuroscience model is a novel approach for training. The program mentors provide a unique multidisciplinary training environment in which to pursue this exciting new approach, given the established collaborations between neuroimaging researchers in the clinical and basic departments of the Perelman School of Medicine and their interface with the Biomedical Graduate Studies program. The University's role at the forefront of neuroimaging and translational neuroscience offers an opportunity to help train the next generation of young scientists who can pursue fundamental questions about abnormalities in brain circuitry in affective illness from the perspective of core psychological, neural and translational mechanisms that can inform and span traditional boundaries of psychopathology and lead to more effective treatments and identification of new targets for prevention.