Flexible Hybrid Cloud Infrastructure for Seamless Management of HuBMAP Resources, Including Consortium-Wide and External Engagement

为匹兹堡超级计算中心HuBMAP蜂窝的基础设施组件(IC)提供 (PSC)和匹兹堡大学(PIT)将在近期创建灵活且可扩展的混合云基础设施 与蜂巢合作实验室、HuBMAP联盟和世界各地的利益相关者进行协调。这项建议 IC将HuBMAP与存储和托管计算资源无缝连接， 查询、搜索、分析和可视化原始和已处理的HuBMAP数据。数据和工具 集成到IC中将是可找到的、可访问的、可互操作的、可重复使用的(公平的)，并放在一起 可在本地和所有主要公共云上运行的可复制、可共享的工作流。IC服务将是 灵活且可扩展，可整合新数据、工具、技术、安全需求、联合身份和用户 角色通过API和容器的模块化架构实现。这些功能使工具既可以快速部署 和可修改的，定义为具有定义的输入和输出的不同功能，使得能够牢固地构造 可重复的管道。IC将为组织结构和功能的研究提供开放的数据平台 通过HuBMAP设想的人体空间框架中的3D生物分子组织图。 我们对HuBMAP基础设施的愿景是灵活、高效地交付HuBMAP的可持续发展目标 平台，由敬业和经验丰富的领导。我们看到基础架构组件扮演着关键的服务角色 其他蜂巢组件、TMC、NIH计划，以及与其他地图集项目的互动。我们的设计是基于 基于现有的大量持久的基础设施，得到许多具有30年历史的项目的支持。在PSC， HuBMAP将以合理的成本持续数十年，并/或与其他项目整合。除了……之外 领导力和扎实的技术专长，我们建议全职项目管理和成像以及 我们团队拥有数据科学方面的专业知识。这些功能将允许基础架构组件员工参与 作为“无时无刻不在”的参与者参与由 HuBMAP计划(例如，HIVE、TMCS、NIH工作人员)。蜂窝的结构使基础设施组件 专注于交付和交付所需的参与度。

To provide for the Infrastructure Component (IC) of the HuBMAP HIVE, Pittsburgh Supercomputing Center (PSC) and the University of Pittsburgh (Pitt) will create a flexible and scalable hybrid cloud infrastructure in close coordination with the HIVE Collaboratory, the HuBMAP Consortium, and stakeholders world wide. This proposed IC will seamlessly connect HuBMAP with storage and co-located compute resources for depositing, accessing, querying, searching, analyzing, and visualizing both raw and processed HuBMAP data. Data and tools incorporated into the IC will be findable, accessible, interoperable, reusable (FAIR), and put together in reproducible, shareable workflows that can be run locally and on all major public clouds. The IC services will be flexible and extensible to incorporate new data, tools, technologies, security needs, federated identity and user roles via modular architecture of APIs and containers. These features enable tools to be both rapidly deployed and modifiable, defined as distinct functions with defined inputs and outputs, enabling solidly constructed repeatable pipelines. The IC will provide the open data platform for study of tissue organization and function through 3D biomolecular tissue maps in the spatial framework of the human body envisioned by HuBMAP. Our vision for the HuBMAP infrastructure is flexible, efficient delivery on HuBMAP’s goals, on sustainable platforms, by engaged and experienced leadership. We see the infrastructure component in a key service role to other HIVE components, TMCs, NIH program, and interacting with other atlas projects. Our design is based upon existing substantial persistent infrastructure supported by many projects with a 30-year history. At PSC, HuBMAP will be sustained for decades at reasonable cost and/or integrate with other programs. In addition to leadership and grounded technology expertise, we are proposing full-time project management and imaging and data science expertise within our team. These capabilities will allow the infrastructure component staff to engage as “ever-present” participants in any aspects of the discussions of the integrated collaboratory conceived by the HuBMAP program (e.g. HIVE, TMCs, NIH staff). The structure of the HIVE enables the infrastructure component to focus on delivery and the engagement required for delivery.