Advanced Tissue Pathology and Imaging Core

摘要 高级组织病理学和成像(ATPI)核心提供了广泛的组织病理学和 满足哥伦比亚大学及其附属机构糖尿病研究人员日益增长的需求的显微镜服务 机构。最初是作为组织病理学实验室组织的，核心已经进化以满足日益增长的 通过增加先进的显微镜服务，满足DRC成员的需求。此核心的服务将继续 包括高质量的基本组织学和显微镜服务，并已扩展到适应 DRC用户不断变化和不断增长的需求，并纳入新开发的试剂和技术。 在前核心主任苏塞尔博士离职后，他领导了大学的芭芭拉·戴维斯中心 科罗拉多州，核心一直由保罗·哈里斯博士干练地领导着，他是一位在小岛上享誉国际的调查员 成像和细胞生物学。在过去的一个周期中，ATPI Core处理了21,312个组织样本，Cut 248,342个切片，进行了21,381个免疫组织化学染色，其中包括4,862个样本 免疫荧光。向30名刚果民主共和国成员提供了这些服务，并得到84笔赠款的支持。这个 由此产生的数据为12份新赠款和93份核心支助出版物(61份为主要出版物， 32作为次要核心)(总表D和F分别)。核心计划继续提供 为蓬勃发展的哥伦比亚大学糖尿病研究社区提供先进的组织表型鉴定能力。至 为此，该中心将其运作与刚果民主共和国其他核心设施的运作结合起来，以维持一名调查员-- 以服务和开发为导向的方法，实施和维持有效的业务实践，以及 协助刚果民主共和国履行其总体使命，促进我们对糖尿病及其并发症和 为这些疾病开发新的治疗方法。

Summary The Advanced Tissue Pathology and Imaging (ATPI) Core provides a wide spectrum of histopathology and microscopy services to meet the growing needs of diabetes researchers at Columbia University and affiliated institutions. Originally organized as a histopathology laboratory, the Core has evolved to meet the growing demands of DRC members by adding advanced microscopy services. The services of this Core continue to include high quality basic histological and microscopy services, and have been expanded to accommodate the changing and growing needs of DRC users and to incorporate newly developed reagents and technologies. Following the departure of former Core Director Dr. Sussel to lead the Barbara Davis Center at the University of Colorado, the Core has been ably led by Dr. Paul Harris, an internationally known investigator in islet imaging and cell biology. During the past cycle, the ATPI Core has processed 21,312 tissue samples, cut 248,342 sections and performed 21,381 immunohistochemical stains, including 4,862 samples by immunofluorescence. These services were provided to 30 DRC members supported by 84 grants. The resultant data have contributed to 12 new grants, and 93 Core-supported publications (61 as primary, 32 as secondary Core) (Overall Tables D and F, respectively). The Core plans to continue to provide advanced histophenotyping capabilities to the thriving Columbia University diabetes research community. To this end, the Core integrates its operation with that of the other DRC Core facilities, to maintain an investigator- oriented approach to service and development, to implement and sustain effective business practices, and to assist the DRC in its overall mission to advance our understanding of diabetes and its complications and develop new treatments for these conditions.