Determinants of Idiopathic Inflammatory Myopathy Associated Interstitial Lung Disease

项目摘要 这一职业发展奖将支持Cheilonda博士的职业发展 约翰霍普金斯大学的全职初级临床研究员约翰逊说。约翰逊博士 建议确定与炎症性肌病相关的遗传和临床决定因素 间质性肺疾病(IIM-ILD)。IM-ILD是一种罕见的高度病态疾病， 影响非裔美国人。不幸的是，IIM-ILD的稀有性和异质性有限 对IIM-ILD危险因素和长期结果进行充足的临床研究。约书亚 霍普金斯大学是完成这项提议的理想环境。约翰逊博士和她的团队 访问欧洲、美国人和非洲人现有的大型HLA分型数据库 来自美国国立卫生研究院的美国人以及一大批特征鲜明的欧洲裔美国人 和来自约翰·霍普金斯肌炎中心和华盛顿大学的非裔美国患者 芝加哥间质性肺病项目。她计划探索人类白细胞抗原I类和II类如何 IIM-ILD、种族/民族背景和肌炎特异性自身抗体影响的相关性 IIM-ILD的临床表型和预后。约翰逊博士接受了极好的训练， 但需要其他技能才能完成当前的提案并实现其最终目标 职业目标是成为专注于种族差异和 自身免疫相关性间质性肺病的疾病变异。这包括(1)附加 设计和分析遗传关联研究的经验，(2)建立 在护理特发性炎症性肌病和相关患者方面有更多的临床专业知识 间质性肺疾病，以及(3)基于以下方面的复杂疾病变异评估培训 种族/民族。她与一群优秀的资深临床科学家合作，他们将 监督她的研究和培训计划的实施。总而言之，这份受过指导的职业生涯 促进生物医学研究教师多样性的发展奖(K01)将支持Dr。 致力于改善临床护理的新兴初级临床研究员Cheilonda Johnson 患有自身免疫相关性间质性肺病的患者。

Project Summary This career development award will support the professional advancement of Dr. Cheilonda Johnson a full-time junior clinical investigator at Johns Hopkins University. Dr. Johnson proposes to identify genetic and clinical determinants of inflammatory myopathy associated interstitial lung disease (IIM-ILD). IM-ILD is a rare highly morbid condition that disproportionately affects African Americans. Unfortunately, the rarity IIM and heterogeneity of IIM-ILD has limited adequately powered clinical studies of IIM-ILD risk factors and long-term outcomes. Johns Hopkins is the ideal environment to complete this proposal. Dr. Johnson and her team have access to a large existing database of HLA typing in European Americans and African Americans from the NIH in addition to a large highly characterized cohort of European American and African American patients from the Johns Hopkins Myositis Center and University of Chicago Interstitial Lung Disease Program. She plans to explore how HLA class I and II associations in IIM-ILD, racial/ethnic background, and myositis specific autoantibodies influence clinical phenotypes and outcomes in IIM-ILD. Dr. Johnson has received excellent training to date but requires additional skills to complete the current proposal and achieve her ultimate career goal to become an expert clinical epidemiologist focusing on racial disparities and disease variation in autoimmune associated interstitial lung disease. This includes (1) additional experience in the design and analysis of genetic association studies, (2) the establishment of more clinical expertise in the care of patients with idiopathic inflammatory myopathy and related interstitial lung disease, and (3) training in the evaluation of complex disease variation based on race/ethnicity. She has partnered with an excellent group of senior clinical scientists who will oversee the conduct of her research and training plan. In summary, this Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research (K01) will support Dr. Cheilonda Johnson an emerging junior clinical investigator working to improve the clinical care of those with autoimmune associated interstitial lung disease.