Gene regulatory and metabolic network structure, function and evolution

基因调控和代谢网络的结构、功能和进化

基本信息

项目摘要

Biological networks describe relationships between biomolecules. We study two types of biological networks and the interactions between them. First, we characterize physical and functional gene regulatory networks that are primary controllers of gene transcription during development and growth, to maintain homeostasis and to respond to environmental cues and insults. We will expand our studies on physical interactions between gene promoters and transcription factors in C. elegans to focus on true functional, tissue-specific regulatory networks in vivo. This will involve the examination of non-transcription factor regulators that affect transcription indirectly. Second, we study metabolic networks that convert nutrients into biomass and energy. We will perform experiments to gain insight into how metabolic networks are wired in different tissues and under different nutritional conditions. In addition, we will continue to develop our WormFlux website to enable data integration and flux balance analysis with selected parameters such as biomass composition and different objective functions. Finally, and importantly, we study how gene regulatory networks affect metabolic networks and vice versa. We will test how intestinal transcription is affected by perturbations in metabolic genes. In addition, we will generate gene expression data under different conditions to examine how gene expression changes influence metabolism. Our data will provide broad phenomenological and deep mechanistic insights, as well as a set of resources for the larger community.
生物网络描述生物分子之间的关系。我们研究两种生物

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

A. J. Marian Walhout其他文献

A. J. Marian Walhout的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('A. J. Marian Walhout', 18)}}的其他基金

Gene regulatory and metabolic network structure, function and evolution
基因调控和代谢网络的结构、功能和进化
  • 批准号:
    9276189
  • 财政年份:
    2017
  • 资助金额:
    $ 81.93万
  • 项目类别:
Gene regulatory and metabolic network structure, function and evolution
基因调控和代谢网络的结构、功能和进化
  • 批准号:
    10604398
  • 财政年份:
    2017
  • 资助金额:
    $ 81.93万
  • 项目类别:
Gene regulatory and metabolic network structure, function and evolution
基因调控和代谢网络的结构、功能和进化
  • 批准号:
    10159103
  • 财政年份:
    2017
  • 资助金额:
    $ 81.93万
  • 项目类别:
Gene regulatory and metabolic network structure, function and evolution
基因调控和代谢网络的结构、功能和进化
  • 批准号:
    10409002
  • 财政年份:
    2017
  • 资助金额:
    $ 81.93万
  • 项目类别:
Modeling of the metabolic network of Caenorhabditis elegans
秀丽隐杆线虫代谢网络的建模
  • 批准号:
    8989126
  • 财政年份:
    2015
  • 资助金额:
    $ 81.93万
  • 项目类别:
Gene-centered protein-RNA interaction mapping
以基因为中心的蛋白质-RNA相互作用作图
  • 批准号:
    8268978
  • 财政年份:
    2011
  • 资助金额:
    $ 81.93万
  • 项目类别:
Gene-centered protein-RNA interaction mapping
以基因为中心的蛋白质-RNA相互作用作图
  • 批准号:
    8139551
  • 财政年份:
    2011
  • 资助金额:
    $ 81.93万
  • 项目类别:
Identifying transcription factor binding sites in the C. elegans genome
鉴定秀丽隐杆线虫基因组中的转录因子结合位点
  • 批准号:
    7897420
  • 财政年份:
    2009
  • 资助金额:
    $ 81.93万
  • 项目类别:
Transcription networks in C elegans organogenesis
线虫器官发生中的转录网络
  • 批准号:
    7865571
  • 财政年份:
    2009
  • 资助金额:
    $ 81.93万
  • 项目类别:
Gene regulatory network structure, function and evolution
基因调控网络的结构、功能和进化
  • 批准号:
    8641704
  • 财政年份:
    2008
  • 资助金额:
    $ 81.93万
  • 项目类别:

相似海外基金

Improving the quality and coherence of biochemical pathway information resources and developing tools to facilitate the investigation of intestinal microflora
提高生化途径信息资源的质量和一致性,开发促进肠道微生物群研究的工具
  • 批准号:
    442760-2013
  • 财政年份:
    2013
  • 资助金额:
    $ 81.93万
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Master's
MouseCyc: A Biochemical Pathway Database for the Mouse
MouseCyc:小鼠生化通路数据库
  • 批准号:
    7351830
  • 财政年份:
    2006
  • 资助金额:
    $ 81.93万
  • 项目类别:
MouseCyc: A Biochemical Pathway Database for the Mouse
MouseCyc:小鼠生化通路数据库
  • 批准号:
    7215571
  • 财政年份:
    2006
  • 资助金额:
    $ 81.93万
  • 项目类别:
MouseCyc: A Biochemical Pathway Database for the Mouse
MouseCyc:小鼠生化通路数据库
  • 批准号:
    7033357
  • 财政年份:
    2006
  • 资助金额:
    $ 81.93万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了