MouseCyc: A Biochemical Pathway Database for the Mouse

我们建议开发MouseCyc，这是一个小鼠的生化途径基因组数据库， 与精心策划的表型信息、基因表达数据、功能注释 和小鼠基因的哺乳动物同源性，可从小鼠基因组信息学（MGI）获得 数据库这项工作的结果将为科学界提供一个关于小鼠遗传学的观点。 以及生物化学和代谢过程背景下的基因组数据。该功能将进一步 提高小鼠作为了解人类生物学和疾病的模型系统的价值 流程. 为了实现MouseCyc，我们将使用一个名为Pathway Tools的强大软件套件， 用于生物体特定生化途径数据的创建、管理和可视化。一旦 MouseCyc实现后，我们将使用来自 已发表的科学文献、其他数据库以及适当的专题专家。获得 MouseCyc将使用包含在 Pathway Tools软件开发工具包。这些数据库还将作为策划鼠标的来源 用于其他途径表示和建模项目的途径数据。我们将携手合作， Pathway Tools软件的开发人员，以实现支持比较 人类和小鼠途径的基础上策划的基因同源性和保守的同线性关系。 与公共卫生的相关性 MouseCyc数据库将作为一个可公开访问的互联网资源， 社区将用于分析小鼠遗传和基因组数据的背景下，生物化学和 代谢过程数据库中的数据管理和表示优先权将给予那些 实验室小鼠中的基因与人类中的基因相似， 疾病MouseCyc的可视化和查询接口将进一步提升鼠标的价值 作为理解人类生物学和疾病过程的模型系统。

We propose to develop MouseCyc, a biochemical pathway genome database for the mouse that is integrated with well-curated information on phenotypes, gene expression data, functional annotations, and mammalian homology for mouse genes that is available from the Mouse Genome Informatics(MGI) database. The results of the proposed work will provide the scientific community a view of mouse genetic and genomic data in the context of biochemical and metabolic processes. This functionality will further enhance the value of the mouse as a model system for understanding human biology and disease processes. To implement MouseCyc we will use a robust software suite called Pathway Tools that has components for the creation, curation, and visualization of organism-specific biochemical pathway data. Once MouseCyc is implemented, we will curate pathway data for the mouse using information from the published scientific literature, other databases and, where appropriate, subject matter experts. Access to MouseCyc will be provided using web-based data query and browsing capabilities that are included in the Pathway Tools software development kit. The databases will also serve as a source of curated mouse pathway data for other pathway representation and modeling projects. We will work collaboratively with the developers of the Pathway Tools software to implement mechanisms to support comparisons of human and mouse pathways based on curated gene homology and conserved synteny relationships. Relevance to Public Health The MouseCyc database will serve as a publicly accessible internet resource that the scientific community will use to analyze mouse genetic and genomic data in the context of biochemical and metabolic processes. Priority for data curation and representation in the database will be given to those genes in the laboratory mouse that have counterparts in humans that are known to be involved in disease. The visualization and query interfaces for MouseCyc will further enhance the value of the mouse as a model system for understanding human biology and disease processes.