MouseCyc: A Biochemical Pathway Database for the Mouse

我们建议开发MouseCyc，一个用于小鼠的生化途径基因组数据库 整合了关于表型、基因表达数据、功能注释、 和哺乳动物的同源性，可从小鼠基因组信息学(MGI)获得小鼠基因 数据库。这项拟议工作的结果将为科学界提供一种关于老鼠基因的观点 以及生化和新陈代谢过程中的基因组数据。这一功能将进一步 加强小鼠作为了解人类生物学和疾病的模型系统的价值 流程。 为了实现MouseCyc，我们将使用称为路径工具的强大软件套件，该套件具有组件 用于创建、管理和可视化特定于生物体的生化途径数据。一次 实现了MouseCyc，我们将使用来自 出版的科学文献、其他数据库以及适当时的专题专家。进入 将使用基于Web的数据查询和浏览功能提供MouseCyc，这些功能包括在 路径工具软件开发工具包。这些数据库还将作为精选鼠标的来源 用于其他路径表示和建模项目的路径数据。我们将与 Path工具软件的开发人员实现了支持比较的机制 人类和小鼠基于精选的基因同源性和保守的共性关系的通路。 与公共卫生的相关性 MouseCyc数据库将作为可公开访问的互联网资源，科学 社区将用于在生化和生物化学的背景下分析小鼠的遗传和基因组数据 代谢过程。数据库中的数据管理和表示将优先考虑下列人员 实验室小鼠的基因，与人类的基因相对应，已知参与了 疾病。MouseCyc的可视化和查询界面将进一步提升鼠标的价值 作为了解人类生物学和疾病过程的模型系统。

We propose to develop MouseCyc, a biochemical pathway genome database for the mouse that is integrated with well-curated information on phenotypes, gene expression data, functional annotations, and mammalian homology for mouse genes that is available from the Mouse Genome Informatics(MGI) database. The results of the proposed work will provide the scientific community a view of mouse genetic and genomic data in the context of biochemical and metabolic processes. This functionality will further enhance the value of the mouse as a model system for understanding human biology and disease processes. To implement MouseCyc we will use a robust software suite called Pathway Tools that has components for the creation, curation, and visualization of organism-specific biochemical pathway data. Once MouseCyc is implemented, we will curate pathway data for the mouse using information from the published scientific literature, other databases and, where appropriate, subject matter experts. Access to MouseCyc will be provided using web-based data query and browsing capabilities that are included in the Pathway Tools software development kit. The databases will also serve as a source of curated mouse pathway data for other pathway representation and modeling projects. We will work collaboratively with the developers of the Pathway Tools software to implement mechanisms to support comparisons of human and mouse pathways based on curated gene homology and conserved synteny relationships. Relevance to Public Health The MouseCyc database will serve as a publicly accessible internet resource that the scientific community will use to analyze mouse genetic and genomic data in the context of biochemical and metabolic processes. Priority for data curation and representation in the database will be given to those genes in the laboratory mouse that have counterparts in humans that are known to be involved in disease. The visualization and query interfaces for MouseCyc will further enhance the value of the mouse as a model system for understanding human biology and disease processes.