Infection and Inflammation as Drivers of Aging (IIDA) Predoctoral Training Program

摘要 我们的世界面临的最深刻的人口变化是 65岁以上的个人，预计在美国将达到8000多万人和12亿人 到2050年在全球范围内。老年人数量的增加对社会经济产生了重大影响。第一, 寿命的延长大大增加了患有多种慢性病的老年人的数量 生活质量下降。其次，管理老年人医疗保健的挑战消耗了 医疗保健资金中不成比例的一大部分。因此，生物医学创新必须以 提高老年人的复原力和健康寿命。大力加强生物医学方面的培训 与老龄化生物学相关的研究对于满足越来越多的老年人的需求至关重要。 在这里，我们提出了一个新的、创新的多学科计划，旨在培养博士前 研究人员(每年4名)，以确定感染和炎症作用的潜在机制 老龄化驱动因素(IIDA)。IIDA培训计划由基础科学家、临床医生和公众组成 亚利桑那大学(UA)的健康导师，一所排名前20的公共研究I大学，因其 基础生物医学研究领域的培训历史及其对指导、多样性的承诺 (指定的拉美裔服务机构)和跨学科培训。在过去的3年里，作为 在生物医学领域史无前例的增长，UA已将衰老研究确定为这四个领域的支柱 UA健康科学的战略倡议，并作为UA学院的十大倡议之一 医学。为了利用这一点，我们提出了一个研究生级别的培训计划，主要有三个主题：(I) 衰老中的炎症和免疫，(Ii)衰老中的持续感染，以及(Iii)炎症和年龄- 相关病理学。支持这一培训计划的21名NIH资助的教职员工具有多样化和强大的 在感染、炎症、免疫学和年龄相关病理学方面的专业知识。培训计划是 由UA在老龄化、基础科学、临床实践和公共卫生方面的一系列优势支持。这个 如果IIDA要利用这些优势，在服务不足的人中开展主要的培训计划，那么目标就是 感染区域和炎症是衰老过程的驱动因素。广泛的制度支持，国家- 最先进的核心设施以及临床和公共卫生指导将增强培训体验， 这也将有一个强有力的代表不足的少数群体(URM)外联和多样性建设的组成部分。 因此，IIDA培训计划将为培训下一代 不同的科学家推动我们对衰老过程的生物学基础的理解并发展 增强复原力和健康寿命的战略。

SUMMARY The most profound demographic change confronting our world is a dramatic increase in individuals over 65 years of age, projected to reach over 80 million people in the US and 1.2 billion worldwide by 2050. The increasing number of older adults has major socioeconomic ramifications. First, the increase in longevity dramatically increases numbers of older adults with multiple chronic diseases and with reduced quality of life. Second, the challenge of managing health care of older adults consumes a disproportionally large segment of health care dollars. Therefore, biomedical innovations must target increasing resilience and healthspan in older adults. Robustly increased training in biomedical sciences pertinent to the biology of aging is critical to address the needs of the growing number of older adults. Here we propose a new, innovative multidisciplinary program designed to train pre-doctoral investigators (4 per year) to define mechanisms underlying the roles of Infection and Inflammation as Drivers of Aging (IIDA). The IIDA training program is comprised of basic scientists, clinicians, and public health mentors at the University of Arizona (UA), a top 20 public Research I University, recognized for its training history in the field of basic biomedical research and for its commitment to mentoring, diversity (designated Hispanic-serving Institution) and cross-disciplinary training. In the last 3 years, as part of unprecedented growth in biomedical sciences, UA has identified research on aging as a pillar of all four strategic initiatives of the UA Health Sciences and as one of top 10 initiatives of the UA College of Medicine. To leverage this, we propose a graduate-level training program with 3 major themes: (i) inflammation and immunity in aging, (ii) persistent infection in aging, and (iii) inflammation and age- related pathology. The 21 NIH-funded faculty supporting this training program have diverse and strong expertise in infection, inflammation, immunology, and age-related pathologies. The training program is supported by a number of UA strengths in aging, basic sciences, clinical practice, and public health. The goal if the IIDA is to harness these strengths towards the premier training program in the underserved area of infection and inflammation as drivers of the aging process. Extensive institutional support, state- of-the-art core facilities, and clinical and public health mentorship will enhance the training experience, that will also have a strong underrepresented minority (URM) outreach and diversity-building component. Thereby, the IIDA training program will provide unique opportunities for training the next generation of diverse scientists to advance our understanding of the biological basis of aging processes and develop strategies to enhance resilience and healthspan.