Infection and Inflammation as Drivers of Aging (IIDA) Predoctoral Training Program

感染和炎症作为衰老驱动因素 (IIDA) 博士前培训计划

• 批准号: 10640924
• 负责人: Felicia D Goodrum
• 金额: $ 19.47万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10640924
• 关键词: Aging; Infection; Inflammation; Training Programs; pre-doctoral

SUMMARY The most profound demographic change confronting our world is a dramatic increase in individuals over 65 years of age, projected to reach over 80 million people in the US and 1.2 billion worldwide by 2050. The increasing number of older adults has major socioeconomic ramifications. First, the increase in longevity dramatically increases numbers of older adults with multiple chronic diseases and with reduced quality of life. Second, the challenge of managing health care of older adults consumes a disproportionally large segment of health care dollars. Therefore, biomedical innovations must target increasing resilience and healthspan in older adults. Robustly increased training in biomedical sciences pertinent to the biology of aging is critical to address the needs of the growing number of older adults. Here we propose a new, innovative multidisciplinary program designed to train pre-doctoral investigators (4 per year) to define mechanisms underlying the roles of Infection and Inflammation as Drivers of Aging (IIDA). The IIDA training program is comprised of basic scientists, clinicians, and public health mentors at the University of Arizona (UA), a top 20 public Research I University, recognized for its training history in the field of basic biomedical research and for its commitment to mentoring, diversity (designated Hispanic-serving Institution) and cross-disciplinary training. In the last 3 years, as part of unprecedented growth in biomedical sciences, UA has identified research on aging as a pillar of all four strategic initiatives of the UA Health Sciences and as one of top 10 initiatives of the UA College of Medicine. To leverage this, we propose a graduate-level training program with 3 major themes: (i) inflammation and immunity in aging, (ii) persistent infection in aging, and (iii) inflammation and age- related pathology. The 21 NIH-funded faculty supporting this training program have diverse and strong expertise in infection, inflammation, immunology, and age-related pathologies. The training program is supported by a number of UA strengths in aging, basic sciences, clinical practice, and public health. The goal if the IIDA is to harness these strengths towards the premier training program in the underserved area of infection and inflammation as drivers of the aging process. Extensive institutional support, state- of-the-art core facilities, and clinical and public health mentorship will enhance the training experience, that will also have a strong underrepresented minority (URM) outreach and diversity-building component. Thereby, the IIDA training program will provide unique opportunities for training the next generation of diverse scientists to advance our understanding of the biological basis of aging processes and develop strategies to enhance resilience and healthspan.

总结 我们世界面临的最深刻的人口变化是人口的急剧增加， 65岁以上的人，预计将达到8000多万人在美国和12亿 到2050年全球老年人人数的增加产生了重大的社会经济影响。第一、 寿命的延长使患有多种慢性疾病的老年人数量急剧增加， 生活质量下降。其次，管理老年人医疗保健的挑战消耗了 一大笔医疗费用因此，生物医学创新必须针对 增加老年人的恢复力和健康寿命。生物医学科学培训大幅增加 与老龄化生物学相关的知识对于满足日益增多的老年人的需求至关重要。 在这里，我们提出了一个新的，创新的多学科计划，旨在培养博士前 研究者（每年4名）定义感染和炎症作用的潜在机制， 老化的驱动因素（IIDA）。IIDA培训计划由基础科学家，临床医生和公众组成。 亚利桑那大学（UA）的健康导师，排名前20位的公立研究型大学，因其 在基础生物医学研究领域的培训历史及其对指导，多样性 （指定的西班牙裔服务机构）和跨学科的培训。在过去的三年里，作为 在生物医学科学前所未有的增长，UA已确定对老龄化的研究作为所有四个支柱 UA健康科学的战略举措，并作为UA大学的十大举措之一， 药为了利用这一点，我们提出了一个研究生水平的培训计划，有3个主要主题：（一） 老化中的炎症和免疫，（ii）老化中的持续感染，和（iii）炎症和老化- 相关病理学21个NIH资助的教师支持这个培训计划具有多样性和强大的 感染、炎症、免疫学和年龄相关病理学方面的专业知识。培训计划是 在老龄化、基础科学、临床实践和公共卫生方面得到了许多UA优势的支持。的 如果IIDA要利用这些优势，在服务不足的地区开展首要的培训计划， 感染和炎症区域作为老化过程的驱动因素。广泛的机构支持，国家- 最先进的核心设施以及临床和公共卫生指导将增强培训体验， 这也将有一个强大的代表性不足的少数群体（URM）的外联和多样性建设的组成部分。 因此，IIDA培训计划将为培训下一代提供独特的机会。 不同的科学家，以促进我们对衰老过程的生物学基础的理解， 加强复原力和健康的战略。