Imaging Cell and Tissue Architecture using Confocal and Super-Resolution Microscopy

使用共焦和超分辨率显微镜对细胞和组织结构进行成像

• 批准号: LE140100166
• 负责人: Prof Peter Gunning
• 金额: $ 24.67万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE140100166
• 关键词: Imaging; Cell; Tissue; Architecture; using

Imaging cell and tissue architecture using confocal and super-resolution microscopy: This project aims to understand how the architecture of cells and tissues is controlled. This is because the organisation of biological space underpins the function of cells, tissues and organisms. This project will test the role of identified parts of cell architecture in regulating specific animal functions/pathologies. It will do this by using new microscope technologies which are at the frontier of visualising cell structure in isolation and in the context of tissue including application to the living animal. The dynamic organisation of structures in cells will be imaged in living tissue. Novel insights into structure/function relationships in the body will impact the health industry and generate opportunities for new diagnostics and therapeutics.

使用共聚焦和超分辨率显微镜成像细胞和组织结构：该项目旨在了解细胞和组织的结构是如何控制的。这是因为生物空间的组织支撑着细胞、组织和有机体的功能。该项目将测试细胞结构的确定部分在调节特定动物功能/病理学中的作用。它将通过使用新的显微镜技术来实现这一点，这些技术处于孤立和组织背景下可视化细胞结构的前沿，包括应用于活体动物。细胞中结构的动态组织将在活组织中成像。对身体结构/功能关系的新见解将影响健康产业，并为新的诊断和治疗带来机会。