A structural HIV prevention intervention targeting high-risk women

针对高危女性的结构性艾滋病毒预防干预措施

• 批准号: 9922254
• 负责人: Susan G. Sherman
• 金额: $ 55.15万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9922254
• 关键词: AIDS prevention; Address; Area; Baltimore; Behavioral; Biological; Caring; Communities; Complex; Cost Measures; Counseling; Crack Cocaine; Cross-Sectional Studies; Dancing; Data; Distant; Drug usage; Education; Effectiveness; Enrollment; Environment; Epidemic; Exposure to; Funding; Geography; Goals; HIV; HIV Infections; HIV risk; HIV/STD; High Risk Woman; Homelessness; Hotlines; Hour; Housing; Human immunodeficiency virus test; Incidence; Infection; Intervention; Interview; Legal; Link; Location; Maryland; Measures; Mediator of activation protein; Medical; National Institute of Drug Abuse; Nature; Occupational activity of managing finances; Opioid; Outcome Study; Participant; Pharmacotherapy; Population; Poverty; Prevention approach; Preventive Intervention; Primary Health Care; Reporting; Reproductive Health; Research; Risk; Risk Behaviors; Risk Reduction; Role; Sampling; Service provision; Services; Sex Behavior; Statistical Data Interpretation; Structure; Testing; Time; Training; Unsafe Sex; Visit; base; behavioral health; behavioral outcome; cocaine use; cohort; comparison group; cost; design; effectiveness evaluation; empowerment; experience; female sex worker; financial literacy; follow-up; geographically distant; high risk; implementation research; innovation; intervention effect; intimate partner violence; member; multidisciplinary; outreach; peer; professional atmosphere; program costs; programs; public health relevance; recruit; referral services; sex; skills; social cohesion; social stigma; social structure; systematic review; theories; therapy development

 DESCRIPTION (provided by applicant): Three decades into the HIV epidemic, high HIV/STI rates persist among FSWs throughout the world, and research on this population in the U.S. is scarce. FSWs experience a unique set of vulnerabilities associated with structural factors such stigma, and unsafe work environments. These factors inhibit protective sexual behaviors and seeking of HIV testing, care, and treatment. HIV prevention approaches that address social and structural vulnerabilities to HIV infection among FSWs have demonstrated effectiveness worldwide. We aim to develop and evaluate the effectiveness of a community-based combination HIV prevention package to include a range of biomedical, behavioral, and structural services, provided through the "STILETTO" Center. Trained peer educators (N=20) will conduct outreach in exotic dance club and street venues, promote the use of the Center, and enact community mobilization. The study's overall goal is to stimulate community empowerment, through such mechanisms as social cohesion and collective action, resulting in sustainable HIV risk reduction. We hypothesize that addressing structural drivers and more immediate medical needs, in combination with peer education, will lead to community empowerment and reduce HIV/STIs incidence and risk. The study aims to: 1) examine the effects of the intervention on FSWs' HIV risk behaviors (drug use/unprotected sex), and HIV/STI cumulative incidence over 18 months in the intervention (n=200) compared to those in the comparison (N=150) communities, and how these changes are associated with intervention exposure; 2) examine how socio-structural (e.g., social cohesion, stigma) and structural vulnerability indicators (e.g., financial and housing stability) change and are associated with the biological and behavioral outcomes over time in intervention (n=200) versus comparison (n=150) participants; and to 3) examine the intervention's implementation through qualitative (e.g., in-depth interviews) and quantitative (e.g., assessment of program fit, reach, facilitators and barriers, and program costs) measures. To achieve these aims, we propose developing and evaluating a theoretically informed, community-based comprehensive intervention comprised of the STILETTO Center, training FSW peer educators (N=20), and a 24-hour crisis hotline line. Our extensive community partners will provide services at the Center, thereby increasing sustainability. The study is innovative in its comprehensive approach targeting U.S. FSWs and addresses the growing call for designing and evaluating structural interventions, a NIDA priority (PA-12-281).

 描述（由申请人提供）：艾滋病毒流行三十年来，世界各地的FSW中艾滋病毒/性传播感染率居高不下，美国对这一人群的研究很少。FSW经历了一系列与耻辱和不安全工作环境等结构性因素相关的独特脆弱性。这些因素抑制了保护性的性行为和寻求艾滋病毒检测，护理和治疗。针对性工作者感染艾滋病毒的社会和结构脆弱性的艾滋病毒预防方法在世界范围内证明是有效的。我们的目标是开发和评估一个以社区为基础的艾滋病毒综合预防包的有效性，包括一系列的生物医学，行为和结构服务，通过“STILETTO”中心提供。受过培训的同伴教育者（N=20）将在异国情调的舞蹈俱乐部和街头场所进行外展，促进中心的使用，并制定社区动员。这项研究的总体目标是通过社会凝聚力和集体行动等机制，促进社区赋权，从而可持续地减少艾滋病毒风险。我们假设，解决结构性驱动因素和更直接的医疗需求，结合同伴教育，将导致社区赋权和减少艾滋病毒/性传播感染的发病率和风险。这项研究的目的是：1）检查干预措施对FSW的艾滋病毒风险行为（吸毒/无保护性行为）的影响，以及与对照社区（N=150）相比，干预社区（n=200）18个月内的艾滋病毒/性传播感染累积发病率，以及这些变化如何与干预暴露相关; 2）检查社会结构（例如，社会凝聚力、耻辱感）和结构脆弱性指标（例如， 金融和住房稳定性）变化，并且与干预（n=200）与比较（n=150）参与者中随时间的生物和行为结果相关;以及3）通过定性（例如，深入访谈）和定量（例如，评估计划的适合性、覆盖范围、促进者和障碍，以及计划成本） 措施为了实现这些目标，我们建议开发和评估一个理论上知情的，以社区为基础的综合干预组成的STILETTO中心，培训FSW同伴教育者（N=20），和24小时危机热线。我们广泛的社区合作伙伴将在中心提供服务，从而提高可持续性。该研究在针对美国FSW的综合方法方面具有创新性，并解决了日益增长的对设计和评估结构性干预措施的需求，这是NIDA的优先事项（PA-12-281）。