权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Metamaterial-Enabled magnetic Resonance Imaging Enhancement

超材料磁共振成像增强

基本信息

批准号：
9923694
负责人：
Stephan William Anderson
金额：
$ 24.75万
依托单位：
BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9923694
关键词：
Address Advanced Development Anatomy Cells Clinic Clinical Contrast Media Development Diagnostic Disease Electromagnetic Energy Electromagnetic Fields Engineering Evolution Exhibits FDA approved Financial cost Gadolinium Goals Healthcare Human Image Image Enhancement Imaging Phantoms Imaging Techniques Ionizing radiation Magnetic Resonance Imaging Modern Medicine Modernization Morphologic artifacts Noise Performance Phase Physiologic pulse Property Protocols documentation Reporting Resolution Safety Scanning Signal Transduction Techniques Technology Thick Thinness Time Tissues Translating Ultrasonography United States Validation Vertebral column Work X-Ray Computed Tomography base clinical imaging design flexibility image processing imaging capabilities imaging platform imaging system improved indexing interest magnetic field metallicity novel operation radio frequency tool trend

项目摘要

Project Summary The proposal herein seeks to potentiate magnetic resonance imaging (MRI) using metamaterials in order to improve signal-to-noise ratio (SNR). MRI represents a cornerstone among the diagnostic tools available in modern healthcare. There has been an ongoing drive towards increasing static magnetic fields of MRI systems over the previous two decades in an effort to improve SNR, which may be translated into improved image resolution or decreasing scan times. However, the development of increasingly powerful magnetic fields incurs several trade-offs, including financial costs, safety concerns, and a host of image artifacts, among others. Alternative approaches that have also been developed in order to improve the overall SNR in MRI include the development of advanced RF coil technologies as well as the use of gadolinium-based contrast agents, both of which are routinely applied in the clinic. More recently, early efforts towards the application of metamaterials in MRI have been reported to enable improvements in SNR and efficiency through their capacity to interact with electromagnetic radiation in a novel fashion. While promising, the reported efforts applying MMs to MRI remain impractical and fail to realize the full potential of these unique materials. In this work, the use of metamaterials in MRI will be more fully developed, allowing for an engineered control of the RF electromagnetic field in MRI. Ultimately, this approach offers the potential to dramatically boost SNR without increasing the static magnetic field of the MRI system. In this work, metamaterials featuring metallic helices will be developed and optimized for operation at both 1.5T and 3.0T MRI platforms. Furthermore, tunable metamaterials based on the integration of a nonlinear material will be designed, yielding the capacity for RF enhancement only during the reception phase of the MRI signal acquisition. Following fabrication, the performance (SNR, image quality) of the metamaterials will be validated at both 1.5T and 3.0T MRI platforms using configurations specifically optimized towards spine imaging. The application of metamaterials in MRI has the potential to be rapidly translated towards the clinic, offering marked enhancements in SNR, image resolution, and scan efficiency, thereby enabling an evolution of the utility of this powerful diagnostic tool.

项目摘要本文中的提议寻求使用超材料来增强磁共振成像（MRI），以便改善信噪比（SNR）。MRI代表了现有诊断工具的基石，现代医疗一直在不断地推动MRI系统的静磁场的增加在过去的二十年中，为了提高SNR，这可以转化为改善的图像质量，分辨率或减少扫描时间。然而，日益强大的磁场的发展引起了几个权衡，包括财务成本、安全问题和大量图像伪影等。为了改善MRI中的总体SNR，还开发了替代方法，包括先进的射频线圈技术的开发以及钆基造影剂的使用，这是临床上的常规应用。最近，早期的努力，对超材料的应用，据报道，MRI能够通过其相互作用的能力来提高SNR和效率。电磁辐射的新方式。虽然前景看好，但将MRI应用于MRI的报告仍在继续不切实际并且不能实现这些独特材料的全部潜力。在这项工作中，使用超材料，将得到更充分的发展，允许对MRI中的RF电磁场进行工程控制。最终，这种方法提供了在不增加静态磁场的情况下显著提高SNR的潜力。 MRI系统的领域。在这项工作中，将开发和优化具有金属螺旋的超材料可在1.5T和3.0T MRI平台上运行。此外，可调谐超材料的基础上，将设计一种非线性材料的集成，仅在发射过程中产生射频增强的能力。 MRI信号采集的接收阶段。在制造之后，性能（SNR，图像质量）超材料将在1.5T和3.0T MRI平台上使用特定配置进行验证优化了脊柱成像。超材料在磁共振成像中的应用具有迅速发展的潜力转化为临床，提供SNR、图像分辨率和扫描效率的显著增强，从而使这种强大的诊断工具的效用得以发展。