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A Genome-Wide Analysis of Nociception Molecules, from Expression to Function

从表达到功能的伤害感受分子的全基因组分析

基本信息

批准号：
9923647
负责人：
William D Tracey
金额：
$ 35.1万
依托单位：
TRUSTEES OF INDIANA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-05 至 2021-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9923647
关键词：
Adhesions Affect Afferent Neurons Animal Model Basal lamina Behavioral Binding Biological Assay Biological Models Collagen Data Dendrites Detection Development Diabetes Mellitus Drosophila genus Epidermis Extracellular Matrix Funding Gene Expression Genes Genetic Genetic Screening Goals Heart Diseases Homologous Gene Human Hypersensitivity Integral Membrane Protein Integrins Ion Channel Laboratories Mechanics Mediating Modeling Molecular Morphology Mutation Nerve Endings Neurons Nociception Nociceptors Orthologous Gene Pain Pain management Pathway interactions Pattern Phenotype Physiological Physiology Play Property Proteins RNA Interference Research Rodent Role Sensory Series Signal Pathway Signal Transduction Smoke Stimulus Syndrome System Testing Thermal Hyperalgesias Tissues cancer pain central sensitization chronic pain discoidin receptor experimental study extracellular gene discovery gene function genetic approach genome-wide analysis in vivo inflammatory pain insight interest knock-down mutant nociceptive response novel novel therapeutics optogenetics pain signal painful neuropathy prescription opioid response

项目摘要

Project Summary Abstract This project seeks to identify new molecular pathways that are involved in pain signaling. The PI has pioneered a system that uses Drosophila as a platform for discovering genes required for the function of nociceptive sensory neurons. Understanding molecular mechanisms in nociceptors is of significance because sensory drive in nociceptors contributes to the development of central sensitization and subsequent chronic pain. Furthermore, congenital pain syndromes are caused by mutations in genes that affect the function of nociceptive sensory afferents in humans. Thus, a fundamental and basic understanding of the molecular mechanisms of nociceptive neurons is important for an understanding of chronic, neuropathic, and inflammatory pain. The laboratory of the PI has conducted a genetic screen which has led to the identification of a set of genes that are of importance to the function of nociceptive neurons. During the funding period experiments will be performed that seek to elucidate the molecular, cellular and physiological mechanisms of these newly implicated molecules.

项目摘要该项目旨在确定参与疼痛信号传导的新分子途径。 PI开创了一个系统，使用果蝇作为发现基因的平台这是伤害感受神经元功能所必需的。了解分子伤害感受器中的感觉驱动具有重要意义，因为伤害感受器中的感觉驱动有助于中枢致敏和随后的慢性疼痛的发展。此外，先天性疼痛综合征是由基因突变引起的，人类伤害性感觉传入的功能。因此，一个基本的和基本的了解伤害感受神经元的分子机制对于了解慢性、神经性和炎性疼痛。PI的实验室进行了一次基因筛选，发现了一组基因，对伤害感受神经元的功能具有重要意义。在供资期间将进行实验，试图阐明分子，细胞和这些新涉及的分子的生理机制。