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Nanoparticle contrast agents for earlier breast cancer detection

用于早期乳腺癌检测的纳米粒子造影剂

基本信息

批准号：
9925060
负责人：
David Peter Cormode
金额：
$ 52.44万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-01 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9925060
关键词：
Address Affect Behavior Biological Blood Blood Circulation Body Weights and Measures Breast Breast Cancer Detection Breast Cancer Early Detection Breast Cancer Model Breast Cancer Risk Factor Breast Cancer Treatment Caliber Claustrophobias Clinical Clinical Chemistry Clinical Data Contrast Media Data Detection Digital Mammography Disease Drug Kinetics Early Diagnosis Effectiveness Elements Encapsulated Equipment Excretory function Formulation Gold High Risk Woman Histology Hour Hypersensitivity Image In Vitro Inductively Coupled Plasma Mass Spectrometry Iodine Kidney Kidney Failure Libraries Magnetic Resonance Imaging Malignant Neoplasms Mammographic screening Mammography Methods Minor Nanosphere Nanostructures Organ Patients Polymers Population Procedures Property Publishing Roentgen Rays Safety Scanning Screening procedure Silver Solubility Specificity Structure System Techniques Testing Time Toxic effect Transgenic Model Translations Variant Woman anti-cancer base biodegradable polymer biomaterial compatibility cancer imaging cancer type comparative contrast enhanced cost cost effective design flexibility high risk high risk population hydrophilicity imaging potential improved in vitro Assay in vivo malignant breast neoplasm mortality nanocrystal nanomaterials nanoparticle novel polyphosphazene prevent public health relevance screening screening program silver sulfide small molecule tool tumor

项目摘要

PROJECT SUMMARY Breast cancer is by far the most common type of cancer and is the second most deadly cancer in women. Breast cancer mammography screening programs for early detection are widespread. Mammography screening reduces mortality from breast cancer and is cost-effective. However, it has emerged that mammography is not very effective in women with dense breasts (about 10% of women), with sensitivity of 30- 60%. Moreover, independent of the lower chance of tumor detection, women with dense breasts are at a higher risk of breast cancer. Therefore to reduce mortality from breast cancer in this population, better screening techniques are needed. Dual-energy mammography has recently emerged as a technique that is highly sensitive and specific for detecting cancer in women with dense breasts. A contrast agent for dual-energy mammography that can identify tumors would be highly beneficial in women with dense breasts, as well as in selected high-risk populations. Currently available iodine-based contrast agents have poor pharmacokinetics, low tumor accumulation and are contraindicated in many patients. While other techniques such as contrast-enhanced MRI can be used for screening women with dense breasts, the high costs and practical obstacles prevent the use of those techniques. We herein propose to develop novel, biodegradable silver-based nanoparticles (SBNP) to allow safe detection of tumors in patients at higher risk of breast cancer. We have found that silver is an element that produces excellent contrast in dual-energy mammography a new variation of mammography where two images are acquired at different x-ray energies. We have found methods that make the nanoparticles stable and biocompatible. We have chosen a comparatively simple, yet flexible nanoparticle design in order to improve the likelihood of translation. The nanoparticles should quickly accumulate in tumors, rendering them conspicuous on mammography, before gradually breaking down into their components for renal excretion. This proposal addresses a key challenge in the use of nanoparticles in cancer: excretion. As part of this proposal we will develop a biodegradable carrier system that can deliver small, highly hydrophilic nanoparticles to tumors, before breakdown and renal excretion. This carrier system could have a broad impact, since it could be applied to numerous different nanoparticle types and anti-cancer approaches.

项目总结