Influence of gut microbiota on vector competence of disease transmitting insects

肠道微生物群对传播疾病的昆虫媒介能力的影响

基本信息

  • 批准号:
    9924459
  • 负责人:
  • 金额:
    $ 14.18万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-04-12 至 2022-03-31
  • 项目状态:
    已结题

项目摘要

Diseases transmitted by insects (vector borne) account for over 17% of the infectious disease burden globally. Most of these diseases lack efficient mammalian vaccines or treatments, and thus heavily rely on vector control to prevent or reduce transmission. Anopheles and tsetse fly are the two vectors involved in malaria and sleeping sickness transmission, respectively. Current vector control methods largely involve the use of insecticides that are environmentally undesirable, and have diminishing efficacy in light of the emergence of insecticide resistance observed in insects. Understanding the mechanisms that influence vector-parasite transmission biology can help develop new control methods. There is growing evidence that the capacity to transmit parasites (vector competence) is influenced by vector innate immune responses and associations with native microbes. The two disease vectors, mosquitoes and tsetse flies, have varying life histories and different associations with gut microbiota. An important component of the innate immune response to pathogens involves Peptidoglycan Recognition Proteins, PGRPs, which recognize pathogen specific molecules and regulate host immune responses that ultimately clear pathogens. We have identified that the PGRP repertoire and functions in tsetse and mosquito vary in accordance with their different life histories and symbiotic associations. We also found that native microbiota influence vector competence through essential roles they play in host immunity and metabolism. This proposal builds on our preliminary studies and expands our previous findings to: 1) characterize and compare PGRP functions that differ in Anopheles and tsetse focusing on PGRP-LB and PGRP-LD and 2) investigate immune and metabolic contribution of the gut microbiota to vector competence. Implementation of our goals will expand our knowledge on 1) the structure and regulation of PGRPs contributing to vector competence, and 2) influence of metabolic interactions between vectors and microbiota on disease transmission traits. These findings have the potential to advance knowledge on tripartite interactions between vectors, symbionts and parasites, and to develop novel targets for disrupting pathogen transmission.
昆虫传播的疾病(媒介传播)占全球传染病负担的17%以上。这些疾病大多缺乏有效的哺乳动物疫苗或治疗方法,因此严重依赖病媒控制来预防或减少传播。按蚊和采采蝇分别是疟疾和昏睡病传播的两种媒介。目前的病媒控制方法主要涉及使用环境不受欢迎的杀虫剂,并且由于在昆虫中观察到杀虫剂抗药性的出现,其药效降低。了解影响媒介寄生虫传播生物学的机制有助于开发新的控制方法。越来越多的证据表明,传播寄生虫的能力(媒介能力)受到媒介先天免疫反应和与本地微生物的联系的影响。蚊子和采采蝇这两种病媒有不同的生活史,与肠道微生物区系有不同的联系。对病原体的先天性免疫反应的一个重要组成部分涉及肽聚糖识别蛋白,它识别病原体特定的分子,并调节宿主免疫反应,最终清除病原体。我们已经确定采采子和蚊子的PGRP谱系和功能随着它们不同的生活史和共生关系而不同。我们还发现,本土微生物区系通过在宿主免疫和新陈代谢中发挥重要作用来影响媒介能力。这一建议建立在我们初步研究的基础上,并将我们以前的发现扩展到:1)表征和比较不同于按蚊和采采集的PGRP功能,重点是PGRP-LB和PGRP-LD;2)调查肠道微生物区系对媒介能力的免疫和代谢贡献。我们目标的实现将扩大我们在1)有助于媒介能力的PGRPs的结构和调控,以及2)媒介和微生物区系之间的代谢相互作用对疾病传播特征的影响方面的知识。这些发现有可能促进对病媒、共生体和寄生虫之间三方相互作用的了解,并开发干扰病原体传播的新靶点。

项目成果

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Jingwen Wang其他文献

Jingwen Wang的其他文献

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{{ truncateString('Jingwen Wang', 18)}}的其他基金

Influence of gut microbiota on vector competence of disease transmitting insects
肠道微生物群对传播疾病的昆虫媒介能力的影响
  • 批准号:
    10117165
  • 财政年份:
    2017
  • 资助金额:
    $ 14.18万
  • 项目类别:

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