Maternal immune activation and adolescent exposure to cannabis in rodents: Do two developmental “hits” lead to schizophrenia-like changes in brain and behaviour?

啮齿类动物的母体免疫激活和青少年接触大麻：两次发育“打击”是否会导致大脑和行为发生类似精神分裂症的变化？

• 批准号: nhmrc : 1109283
• 负责人: A/Pr Juanita Todd
• 金额: $ 43.64万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/maternal-immune-activation-brain-behaviour/663077
• 关键词: Maternal; immune; activation; adolescent; exposure

The cause of schizophrenia most likely lies in early brain development due to either genetics or adverse environments. We will examine two successive environmental ‘hits’ in a rat model: infection during pregnancy followed by early adolescent cannabis use. We will track changes in the brain that occur in late adolescence and in young adults. We will also assess behaviour and brain function in adulthood to see if the animals exhibit patterns that mimic those that we see in schizophrenia.

精神分裂症的原因最有可能在于由于遗传或不利环境导致的早期大脑发育。我们将在大鼠模型中研究两个连续的环境“命中”：怀孕期间的感染，随后是青少年早期使用大麻。我们将跟踪青春期后期和年轻人大脑中发生的变化。我们还将评估成年后的行为和大脑功能，看看这些动物是否表现出模仿我们在精神分裂症中看到的模式。