The effects of maternal infection on glutamate-related behavioural, electrophysiological and neuropathological measures relevant to schizophrenia

点击翻译按钮获取中文摘要

There are two well known facts about schizophrenia: maternal infection increases the risk of a schizophrenia diagnosis in adulthood and certain drugs, such as PCP, that affect particular brain chemicals induce symptoms and brain changes in healthy individuals that are similar to schizophrenia. Here we bring these two facts together by attempting to develop a maternal infection model in rodents that mimics the brain changes seen in schizophrenia, thus opening up new options for treatment.