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Dissecting serotonergic and dopaminergic contributions to the neural circuits underlying impulsive behavior.

剖析血清素能和多巴胺能对冲动行为背后的神经回路的贡献。

基本信息

批准号：
9925296
负责人：
Katherine M Nautiyal
金额：
$ 24.9万
依托单位：
DARTMOUTH COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2021-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9925296
关键词：
Adult Advanced Development Aggressive behavior Antisocial Personality Disorder Attention deficit hyperactivity disorder Basic Science Behavior Behavioral Paradigm Binge Eating Binge eating disorder Bipolar Disorder Calcium Cells Chronic Clinical Research Cognitive Complex Conduct Disorder Data Development Dimensions Disease Disinhibition Dopamine Dopamine Agonists Dopamine D1 Receptor Dopamine D2 Receptor Financial Hardship Foundations Genetic Polymorphism Head Health Human Image Imaging Device Imaging Techniques Imaging technology Impulsive Behavior Impulsivity Knock-out Knockout Mice Knowledge Learning Link Manic Maps Measures Mental disorders Mentorship Methods Microscope Motor Mus Neurons Nucleus Accumbens Pathogenesis Pharmacological Treatment Phenotype Play Population Psychiatric therapeutic procedure Regulation Research Research Personnel Research Training Rodent Serotonin Serotonin Receptor 5-HT1B Signal Transduction Societies Techniques Time Tissues Training Transgenic Mice Transgenic Organisms Ventral Tegmental Area Viral Work addiction career design experimental study gamma-Aminobutyric Acid genetic technology imaging modality improved in vivo calcium imaging in vivo imaging knock-down mouse model neural circuit neural correlate novel public health relevance receptor relating to nervous system response skills trait impulsivity

项目摘要

DESCRIPTION (provided by applicant): Impulsive behavior is characterized as acting without forethought and lacking the ability to withold responses. Disordered impulsivity is a major feature of a number of psychiatric disorders including attention deficit hyperactivity disorder (ADHD), conduct disorder, and antisocial personality disorder, as well as binge eating and manic episodes in bipolar disorders. Pharmacological treatments for impulsive behavior are inadequate, and a limiting factor in the development of new pharmacological treatments is a lack of understanding of the neural circuits underlying impulsivity. In the proposed research, I aim to extend progress in this field by using novel transgenic and in vivo imaging tools to study the neural circuitry underlying impulsivity. My previous work shows that adult expression of the serotonin 1B receptor (5-HT1BR) on non-serotonergic cells influences the impulsive action (response inhibition) component of impulsivity. The experiments in this project aim to characterize the scope of 5-HT1BR modulation of the multiple subcomponents of impulsivity including impulsive choice (deferred gratification). Additionally, I will identify the population(s of 5-HT1BRs that contribute to impulsive behavior and define the neural circuit mechanisms. Lastly, through the use of state-of- the-art in vivo calcium imaging methods, the effect of 5-HT1BRs on nodes of the neural circuits will be measured during impulsive behaviors. These studies will serve as a foundation for translational projects investigating the neural basis of disordered impulsivity with the aim to identify targets for the development of new treatments for psychiatric disorders in which impulsivity is a key component. Additionally, this project will provide me with career mentorship as well as technical, statistical, and theoretical training to enable my transition to an independent primary investigator.