Dissecting serotonergic and dopaminergic contributions to the neural circuits underlying impulsive behavior.
Dissecting serotonergic and dopaminergic contributions to the neural circuits underlying impulsive behavior.
批准号:
9925296
负责人:
Katherine M Nautiyal
金额:
$24.9万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-07-01 至 2021-10-31
关键词:
AdultAdvanced DevelopmentAggressive behaviorAntisocial Personality DisorderAttention deficit hyperactivity disorderBasic ScienceBehaviorBehavioral ParadigmBinge EatingBinge eating disorderBipolar DisorderCalciumCellsChronicClinical ResearchCognitiveComplexConduct DisorderDataDevelopmentDimensionsDiseaseDisinhibitionDopamineDopamine AgonistsDopamine D1 ReceptorDopamine D2 ReceptorFinancial HardshipFoundationsGenetic PolymorphismHeadHealthHumanImageImaging DeviceImaging TechniquesImaging technologyImpulsive BehaviorImpulsivityKnock-outKnockout MiceKnowledgeLearningLinkManicMapsMeasuresMental disordersMentorshipMethodsMicroscopeMotorMusNeuronsNucleus AccumbensPathogenesisPharmacological TreatmentPhenotypePlayPopulationPsychiatric therapeutic procedureRegulationResearchResearch PersonnelResearch TrainingRodentSerotoninSerotonin Receptor 5-HT1BSignal TransductionSocietiesTechniquesTimeTissuesTrainingTransgenic MiceTransgenic OrganismsVentral Tegmental AreaViralWorkaddictioncareerdesignexperimental studygamma-Aminobutyric Acidgenetic technologyimaging modalityimprovedin vivo calcium imagingin vivo imagingknock-downmouse modelneural circuitneural correlatenovelpublic health relevancereceptorrelating to nervous systemresponseskillstrait impulsivity
中文摘要
英文摘要
DESCRIPTION (provided by applicant): Impulsive behavior is characterized as acting without forethought and lacking the ability to withold responses. Disordered impulsivity is a major feature of a number of psychiatric disorders including attention deficit hyperactivity disorder (ADHD), conduct disorder, and antisocial personality disorder, as well as binge eating and manic episodes in bipolar disorders. Pharmacological treatments for impulsive behavior are inadequate, and a limiting factor in the development of new pharmacological treatments is a lack of understanding of the neural circuits underlying impulsivity. In the proposed research, I aim to extend progress in this field by using novel transgenic and in vivo imaging tools to study the neural circuitry underlying impulsivity. My previous work shows that adult expression of the serotonin 1B receptor (5-HT1BR) on non-serotonergic cells influences the impulsive action (response inhibition) component of impulsivity. The experiments in this project aim to characterize the scope of 5-HT1BR modulation of the multiple subcomponents of impulsivity including impulsive choice (deferred gratification). Additionally, I will identify the population(s of 5-HT1BRs that contribute to impulsive behavior and define the neural circuit mechanisms. Lastly, through the use of state-of- the-art in vivo calcium imaging methods, the effect of 5-HT1BRs on nodes of the neural circuits will be measured during impulsive behaviors. These studies will serve as a foundation for translational projects investigating the neural basis of disordered impulsivity with the aim to identify targets for the development of new treatments for psychiatric disorders in which impulsivity is a key component. Additionally, this project will provide me with career mentorship as well as technical, statistical, and theoretical training to enable my transition to an independent primary investigator.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
DIY-NAMIC Behavior: A High-Throughput Method to Measure Complex Phenotypes in the Homecage.
DIY-NAMIC 行为:一种测量 Homecage 中复杂表型的高通量方法。
DOI:
10.1523/eneuro.0160-20.2020
发表时间:
2020
期刊:
eNeuro
影响因子:
3.4
作者:
[Lee,JunHo, Capan,Selin, Lacefield,Clay, Shea,YvonneM, Nautiyal,KatherineM]
通讯作者:
Nautiyal,KatherineM
DOI:
10.1111/nyas.13356
发表时间:
2017-04
期刊:
Annals of the New York Academy of Sciences
影响因子:
5.2
作者:
[Nautiyal KM, Okuda M, Hen R, Blanco C]
通讯作者:
Blanco C
Serotonin modulation of the development of neural circuits underlying reward processing and impulsivity in adolescents
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批准号:10381539
-
项目类别:
-
资助金额:$60.42万
-
财政年份:2021
-
负责人:Katherine M Nautiyal
-
依托单位:
Serotonin modulation of the development of neural circuits underlying reward processing and impulsivity in adolescents
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批准号:10200242
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项目类别:
-
资助金额:$56.9万
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财政年份:2021
-
负责人:Katherine M Nautiyal
-
依托单位:
Serotonin modulation of the development of neural circuits underlying reward processing and impulsivity in adolescents
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批准号:10569661
-
项目类别:
-
资助金额:$55.53万
-
财政年份:2021
-
负责人:Katherine M Nautiyal
-
依托单位:
Dissecting serotonergic and dopaminergic contributions to the neural circuits underlying impulsive behavior.
-
批准号:9690972
-
项目类别:
-
资助金额:$24.9万
-
财政年份:2018
-
负责人:Katherine M Nautiyal
-
依托单位:
Dissecting serotonergic and dopaminergic contributions to the neural circuits underlying impulsive behavior
-
批准号:9903618
-
项目类别:
-
资助金额:$9.32万
-
财政年份:2018
-
负责人:Katherine M Nautiyal
-
依托单位:
Genetic and Optogenetic Models to Dissect the Role of the Serotonin 1B Receptor
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批准号:8685028
-
项目类别:
-
资助金额:$5.51万
-
财政年份:2013
-
负责人:Katherine M Nautiyal
-
依托单位:
Genetic and Optogenetic Models to Dissect the Role of the Serotonin 1B Receptor
-
批准号:8527294
-
项目类别:
-
资助金额:$5.22万
-
财政年份:2013
-
负责人:Katherine M Nautiyal
-
依托单位:
Beyond allergy: Mast cells mediate brain-behavior-immune interactions.
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批准号:7929482
-
项目类别:
-
资助金额:$2.2万
-
财政年份:2009
-
负责人:Katherine M Nautiyal
-
依托单位:
海外基金