Acute Effects of Alcohol Use on Chronic Orofacial Pain

饮酒对慢性口面部疼痛的急性影响

• 批准号: 9926778
• 负责人: Jeffrey B Boissoneault
• 金额: $ 18.11万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-10 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9926778
• 关键词: Absence of pain sensation; Acute; Acute Pain; Address; Adult; Affect; Alcohol consumption; Alcoholism; Alcohols; Analgesics; Animals; Attenuated; Behavior; Brain region; Characteristics; Chronic; Clinical; Consumption; Data; Development; Dose; Drug Interactions; Expectancy; Feeling; Future; General Population; Goals; Health; Impairment; Individual; Injury; Intuition; Knowledge; Laboratories; Literature; Masseter Muscle; Medial; Modeling; Moods; Motivation; Negative Reinforcer; Neuropathy; Nucleus Accumbens; Opioid; Orofacial Pain; Pain; Pain management; Pain-Free; Patients; Pattern; Personality; Placebo Effect; Placebos; Prefrontal Cortex; Property; Rattus; Research; Risk; Risk Behaviors; Role; Self Administration; Self Medication; Sensory; Temporomandibular Joint Disorders; Testing; alcohol effect; alcohol response; alcohol sensitivity; alcohol use disorder; base; biopsychosocial; breath alcohol measurement; chronic pain; chronic pain patient; clinical pain; clinically relevant; comparison group; conditioning; drinking; expectation; experience; neurobehavioral; pain patient; pain relief; pain sensation; pain sensitivity; painful neuropathy; pressure; psychologic; response

Project Summary/Abstract It has long been suggested that alcohol has analgesic properties. Data suggest that about 25% of chronic orofacial pain patients endorse the use of alcohol for pain management. However, the biopsychosocial mechanisms underlying this intuitive interaction are not well established. Studies of healthy individuals using quantitative sensory testing (QST) have shown that familial risk for alcoholism, as well as psychological characteristics like mood and personality, may act as critical factors modulating individuals’ sensitivity to alcohol analgesia. However, to our knowledge, the acute pain-relieving effect of alcohol intake in individuals with chronic pain has never been systematically studied. This relationship is important to understand because alcohol analgesia may be associated with relief. Relief from pain may act as a potent negative reinforcer for alcohol intake, which, in turn, can have adverse health effects by increasing risk of developing an alcohol use disorder in people with chronic pain. Self-medication of pain with alcohol may also result in harmful drug interactions, risk of injury due to neurobehavioral impairment, and even development of painful alcohol neuropathy. The overall goal of this proposal is to test the analgesic effects of acute alcohol consumption in individuals with chronic pain and a comparison group of pain-free controls, and identify critical biopsychosocial modulators of alcohol analgesia. These efforts will inform research and clinical/translational efforts regarding modifiable and unmodifiable factors related to risk associated with self-medication of chronic pain using alcohol, and provide critical feasibility and effect size data for future proposals

项目概要/摘要 长期以来，人们一直认为酒精具有镇痛作用。数据表明，大约 25% 的慢性 口面部疼痛患者赞成使用酒精来控制疼痛。然而，生物心理社会 这种直观交互的机制尚未得到很好的建立。对健康个体的研究使用 定量感官测试（QST）表明，酗酒的家族风险以及心理因素 情绪和性格等特征可能是调节个人敏感度的关键因素 酒精镇痛。然而，据我们所知，饮酒对个体的急性疼痛缓解作用 与慢性疼痛的关系从未被系统地研究过。理解这种关系很重要，因为 酒精镇痛可能与缓解有关。缓解疼痛可能是一种有效的负面强化物 酒精摄入量反过来会增加酗酒的风险，从而对健康产生不利影响 患有慢性疼痛的人的疾病。用酒精自我治疗疼痛也可能导致有害药物 相互作用、因神经行为损伤而受伤的风险，甚至产生痛苦的酒精 神经病。该提案的总体目标是测试急性饮酒的镇痛效果 患有慢性疼痛的个体和无痛对照组的对照组，并确定关键的生物心理社会 酒精镇痛调节剂。这些努力将为以下方面的研究和临床/转化工作提供信息 与使用慢性疼痛自我治疗相关的风险相关的可改变和不可改变的因素 酒精，并为未来的提案提供关键的可行性和效果大小数据

项目成果

Analgesic effects of alcohol in adults with chronic jaw pain.

• DOI: 10.1111/acer.14883
• 发表时间: 2022-08
• 期刊: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
• 作者: Vitus, Darya;Williams, Michelle K.;Rizk, Mehdi;Neubert, John K.;Robinson, Michael;Boissoneault, Jeff
• 通讯作者: Boissoneault, Jeff