Acute Effects of Alcohol Use on Chronic Orofacial Pain

饮酒对慢性口面部疼痛的急性影响

• 批准号: 9926778
• 负责人: Jeffrey B Boissoneault
• 金额: $ 18.11万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-10 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9926778
• 关键词: Absence of pain sensation; Acute; Acute Pain; Address; Adult; Affect; Alcohol consumption; Alcoholism; Alcohols; Analgesics; Animals; Attenuated; Behavior; Brain region; Characteristics; Chronic; Clinical; Consumption; Data; Development; Dose; Drug Interactions; Expectancy; Feeling; Future; General Population; Goals; Health; Impairment; Individual; Injury; Intuition; Knowledge; Laboratories; Literature; Masseter Muscle; Medial; Modeling; Moods; Motivation; Negative Reinforcer; Neuropathy; Nucleus Accumbens; Opioid; Orofacial Pain; Pain; Pain management; Pain-Free; Patients; Pattern; Personality; Placebo Effect; Placebos; Prefrontal Cortex; Property; Rattus; Research; Risk; Risk Behaviors; Role; Self Administration; Self Medication; Sensory; Temporomandibular Joint Disorders; Testing; alcohol effect; alcohol response; alcohol sensitivity; alcohol use disorder; base; biopsychosocial; breath alcohol measurement; chronic pain; chronic pain patient; clinical pain; clinically relevant; comparison group; conditioning; drinking; expectation; experience; neurobehavioral; pain patient; pain relief; pain sensation; pain sensitivity; painful neuropathy; pressure; psychologic; response

Project Summary/Abstract It has long been suggested that alcohol has analgesic properties. Data suggest that about 25% of chronic orofacial pain patients endorse the use of alcohol for pain management. However, the biopsychosocial mechanisms underlying this intuitive interaction are not well established. Studies of healthy individuals using quantitative sensory testing (QST) have shown that familial risk for alcoholism, as well as psychological characteristics like mood and personality, may act as critical factors modulating individuals’ sensitivity to alcohol analgesia. However, to our knowledge, the acute pain-relieving effect of alcohol intake in individuals with chronic pain has never been systematically studied. This relationship is important to understand because alcohol analgesia may be associated with relief. Relief from pain may act as a potent negative reinforcer for alcohol intake, which, in turn, can have adverse health effects by increasing risk of developing an alcohol use disorder in people with chronic pain. Self-medication of pain with alcohol may also result in harmful drug interactions, risk of injury due to neurobehavioral impairment, and even development of painful alcohol neuropathy. The overall goal of this proposal is to test the analgesic effects of acute alcohol consumption in individuals with chronic pain and a comparison group of pain-free controls, and identify critical biopsychosocial modulators of alcohol analgesia. These efforts will inform research and clinical/translational efforts regarding modifiable and unmodifiable factors related to risk associated with self-medication of chronic pain using alcohol, and provide critical feasibility and effect size data for future proposals

项目总结/文摘

项目成果

Analgesic effects of alcohol in adults with chronic jaw pain.

• DOI: 10.1111/acer.14883
• 发表时间: 2022-08
• 期刊: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
• 作者: Vitus, Darya;Williams, Michelle K.;Rizk, Mehdi;Neubert, John K.;Robinson, Michael;Boissoneault, Jeff
• 通讯作者: Boissoneault, Jeff