权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Evaluation of the Neuromodulatory Mechanisms of Vagus Nerve Stimulation to Improve Motor Rehabilitation after Stroke

迷走神经刺激改善中风后运动康复的神经调节机制评估

基本信息

批准号：
9973199
负责人：
SETH ALANSON HAYS
金额：
$ 33.47万
依托单位：
UNIVERSITY OF TEXAS DALLAS
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-06-15 至 2022-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9973199
关键词：
Acetylcholine Activities of Daily Living Anatomy Area Basal Nucleus of Meynert Basic Science Brain Injuries Cell Nucleus Cerebral hemisphere hemorrhage Data Development Disease Electric Stimulation Evaluation Exhibits Forelimb Future Goals Human Impairment Intervention Ischemic Stroke Lesion Modeling Motor Motor Cortex Movement Neuromodulator Neuronal Plasticity Norepinephrine Outcome Study Pathway interactions Patients Pharmacology Rattus Recovery Recovery of Function Rehabilitation therapy Role Spinal Stroke System Techniques Testing Therapeutic Intervention Training Translations Traumatic Brain Injury Upper Extremity Viral behavior test cholinergic disability experimental study improved improved functioning insight ischemic lesion locus ceruleus structure motor function recovery motor recovery motor rehabilitation neuroregulation noradrenergic post stroke pre-clinical rehabilitation strategy safety study stroke model stroke patient stroke rehabilitation stroke therapy vagus nerve stimulation

项目摘要

PROJECT ABSTRACT Stroke is a leading cause of disability, with an estimated 795,000 cases in the US each year. As many as 70% of patients who suffer a stroke exhibit long-term impairment in upper extremity motor function. The development of rehabilitative strategies to improve the recovery of motor function is of key importance. Neuroplasticity is believed to support recovery after stroke; therefore, manipulations that enhance plasticity may increase recovery. Stimulation of the vagus nerve during motor training drives robust, specific neuroplasticity in rat motor cortex. Recent evidence indicates that vagus nerve stimulation (VNS) delivered during rehabilitative training significantly improves recovery of forelimb function in multiple models of stroke, but the mechanisms underlying VNS-dependent enhancement of recovery are not defined. The cholinergic and noradrenergic neuromodulatory systems are engaged by VNS and represent potential pathways through which VNS may support recovery. We propose to delineate the neuromodulatory pathways and mechanisms by which VNS acts to increase recovery of forelimb motor function after stroke. The first aim of the study will determine whether the cholinergic and noradrenergic systems are required for VNS-dependent enhancement of recovery after stroke. The second aim of the study will evaluate whether direct stimulation of the cholinergic or noradrenergic systems during rehabilitative training is sufficient to enhance recovery. The third aim of the proposal will examine whether anatomical reorganization in descending motor networks is enhanced by VNS therapy to support functional recovery. The results of the proposed experiments will delineate the neuromodulatory pathways and mechanisms by which VNS paired with rehabilitative training enhances recovery after stroke. Insights from these studies will help to determine whether common disease-related and pharmacological factors that influence these neuromodulatory systems may interfere with the beneficial effects of VNS. Ultimately, results from this study will improve the likelihood of successful translation of VNS therapy for stroke patients.

项目摘要中风是导致残疾的主要原因，在美国每年估计有795，000例。多达70% 的中风患者表现出上肢运动功能的长期损伤。的制定康复策略以改善运动功能的恢复至关重要。神经可塑性被认为有助于中风后的恢复;因此，可能会增加恢复。在运动训练中刺激迷走神经，大鼠运动皮层的神经可塑性。最近的证据表明，迷走神经刺激（VNS）提供在康复训练期间显著改善多种中风模型中前肢功能的恢复，但是没有定义VNS依赖的恢复增强的基础机制。胆碱能和去甲肾上腺素能神经调节系统参与VNS，并代表了潜在的途径， VNS可以支持恢复。我们建议通过以下方法来描述神经调节通路和机制：其中VNS用于增加中风后前肢运动功能的恢复。研究的第一个目标是确定VNS依赖性增强是否需要胆碱能和去甲肾上腺素能系统中风后的恢复本研究的第二个目的是评估是否直接刺激胆碱能神经元，或去甲肾上腺素能系统在康复训练期间足以增强恢复。第三个目标一项提案将研究VNS是否能增强下行运动网络的解剖重组支持功能恢复的治疗。本实验的结果将描述神经调节通路和机制，迷走神经刺激配合康复训练可促进卒中后的恢复。从这些研究中获得的见解将有助于确定是否常见的疾病相关和药理因素，影响这些神经调节系统可能干扰VNS的有益作用。最终，这项研究的结果将提高VNS治疗中风患者成功转化的可能性。