Modeling and Interacting with the Visible Molecular Cell
Modeling and Interacting with the Visible Molecular Cell
批准号:
9975197
负责人:
DAVID S GOODSELL
金额:
$47.34万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-09-15 至 2021-09-30
关键词:
3-DimensionalAddressAppearanceBacteriaBacterial ModelBiological ModelsBiologyCell modelCell physiologyCellsCellular biologyCollaborationsComplexComputer AssistedComputer softwareCrowdingData SetDatabasesDevelopmentDiseaseEducationEducation and OutreachEducational CurriculumEnvironmentEscherichia coliGenomicsGoalsHIVInterventionLipopolysaccharidesMembraneMethodsModelingMolecularOrganismPeptidoglycanPilot ProjectsPlanet EarthPolyribosomesProteomicsRecipeResearchResearch PersonnelResolutionRunningScientistSpecialistSpecific qualifier valueStructural ModelsStructureTechnologyTimeViolaVisualizationVisualization softwareWorkbasecrosslinkfluorescence imagingmethod developmentmolecular assembly/self assemblymultiscale dataoutreachprototypesimulationstructured datathree-dimensional modelingtool
中文摘要
项目总结/文摘
英文摘要
Project Summary/Abstract
It is now possible to approach the structural modeling and visualization of entire cells
with detail at the atomic level. In this project, we will expand the capabilities of
cellPACK, a method for creating integrative 3D models of cellular environments,
bridging from the level of atoms to the level of cells. These models will provide
unprecedented possibilities for the understanding of cellular function and disease states,
enabling new opportunities for intervention. They will also challenge several aspects of
the technologies needed to generate, visualize and interactively explore very large 3D
and 4D structural datasets. Our goal is to develop the modeling and visualization tools
that enable others to develop, run and analyze dynamic simulations of these complex
models. Several critical barriers must be overcome to make this effort a successful tool
for research and scientific education, including the management of large informational
databases, methods for the automated modeling of the structure and interaction of
soluble, fibrous, and membrane-bound molecular assemblies in crowded cellular
environments, and comprehensible visualization of, and interaction with these large and
heterogenous models. We will approach these challenges with four specific aims:
1) Procedural methods for mesoscale modeling of complex assemblies, such as the
bacterial nucleoid, peptidoglycan, lipopolysaccharide, and polysomes;
2) Computer-assisted tools for the management of complex multiscale data for
specifying 3D mesoscale models of cells;
3) Development of fast and effective methods to allow display of and interaction with
these complex mesoscale models;
4) Application of these methods to research in bacterial biology and creation of a Google
Earth inspired viewer for use in education and outreach.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Modeling and Interacting with the Visible Molecular Cell
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批准号:9532908
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项目类别:
-
资助金额:$47.34万
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财政年份:2016
-
负责人:DAVID S GOODSELL
-
依托单位:
Modeling and Interacting with the Visible Molecular Cell
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批准号:10689043
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项目类别:
-
资助金额:$45.45万
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财政年份:2016
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负责人:DAVID S GOODSELL
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依托单位:
Modeling and Interacting with the Visible Molecular Cell
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批准号:10443244
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项目类别:
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资助金额:$44.91万
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财政年份:2016
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负责人:DAVID S GOODSELL
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依托单位:
The Protein Structure Initiative Knowledgebase
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批准号:8152850
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项目类别:
-
资助金额:$2.03万
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财政年份:2010
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负责人:DAVID S GOODSELL
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依托单位:
Structure and Computational Modeling
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批准号:7434200
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项目类别:
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资助金额:$19.41万
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财政年份:2008
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负责人:DAVID S GOODSELL
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依托单位:
The Protein Structure Initiative Knowledgebase
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批准号:8377321
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项目类别:
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资助金额:$1.91万
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财政年份:--
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负责人:DAVID S GOODSELL
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依托单位:
The Protein Structure Initiative Knowledgebase
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批准号:8692859
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项目类别:
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资助金额:$2.06万
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财政年份:--
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负责人:DAVID S GOODSELL
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依托单位:
The Protein Structure Initiative Knowledgebase
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批准号:8502690
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项目类别:
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资助金额:$1.98万
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财政年份:--
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负责人:DAVID S GOODSELL
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依托单位:
The Protein Structure Initiative Knowledgebase
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批准号:8303269
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项目类别:
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资助金额:$1.99万
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财政年份:--
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负责人:DAVID S GOODSELL
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依托单位:
海外基金