Center for Prevention Implementation Methodology for Drug Abuse and HIV (Ce-PIM)

药物滥用和艾滋病毒预防实施方法中心 (Ce-PIM)

• 批准号: 9975784
• 负责人: C. HENDRICKS BROWN
• 金额: $ 104.09万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9975784
• 关键词: AIDS prevention; AIDS/HIV problem; Address; Affect; Age; Anti-Retroviral Agents; Back; Behavior; Biological Models; Biomedical Research; Communities; Community Healthcare; Complex; Decision Making; Development; Discrimination; Drug abuse; Drug usage; Early identification; Early treatment; Effectiveness; Engineering; Environmental Risk Factor; Ethnic Origin; Ethnic group; Feedback; Gender; Gender Identity; Generations; Goals; Grant; HIV; HIV Infections; HIV Seropositivity; HIV risk; Hand; Health; Health Services Accessibility; Healthcare Systems; Heroin; High Prevalence; Human immunodeficiency virus test; Incidence; Individual; Intervention; Knowledge; Long-Term Care; Measurement; Mentors; Methamphetamine; Methodology; Methods; Modeling; Movement; Municipalities; National Institute of Drug Abuse; Outcome; Pattern; Persons; Pharmaceutical Preparations; Play; Policies; Population; Prevention; Prevention approach; Prevention program; Public Health; Publishing; Qualifying; Quality of life; Race; Research; Research Design; Research Personnel; Resources; Risk; Role; Science; Seeds; Services; Sex Orientation; Structure; System; Technology; Testing; Training; United States Substance Abuse and Mental Health Services Administration; Viral Load result; Virus; Vision; Work; antiretroviral therapy; base; black men who have sex with men; career; cocaine use; design; ecstasy; effectiveness trial; efficacy trial; ethnic minority population; health care delivery; implementation research; implementation science; implementation strategy; implementation trial; improved; innovation; men who have sex with men; minority communities; next generation; novel; pre-exposure prophylaxis; prevent; programs; racial and ethnic; ranpirnase; research to practice; scientific organization; social; social stigma; socioeconomics; success; support tools; tool; transmission process; young men who have sex with men

PROJECT SUMMARY/ABSTRACT This application is for a competing renewal of the Center for Prevention Implementation Methodology for HIV and Drug Abuse, a NIDA P30 Center of Excellence. The number of new HIV cases in the US remains stable at 56,000 per year and continues to disproportionately affect some groups, including young men who have sex with men (YMSM), especially from racial/ethnic minorities. The purpose of this methodology center is to develop new methodologies that can be used by federal and local agencies and communities to reduce HIV incidence. Biomedical interventions and strategies, including pre-exposure prophylaxis (PrEP), rapid testing for HIV and early and consistent treatment for persons who are HIV positive (Treatment as Prevention, TasP) have been shown to have high efficacy and effectiveness in reducing HIV transmission, but there remains a giant gap between what research knows and what services needed to reduce population level incidence of HIV. The major premise of this application is that the effective biomedical to reduce HIV incidence and disparities are in hand, but success will only be achieved when they are implemented in ways that meet individual, community, and health care delivery system needs. This methods proposal addresses this major gap between research and practice through implementation science and methodology, focusing on innovative ways to address the complex, mulitilevel interactions needed to implement HIV prevention programs effectively. Two Cores, an Administrative Core and an Innovative Implementation Methods Core for HIV and Drug Abuse will carry out this work. Aim 1 is to develop innovative methods to maximize the impact of implementation research in HIV prevention. We do this through an extended set of systems science and engineering methods that focus on improving the measurement of implementation, the modeling of implementation strategies, and the testing of implementation strategies through rigorous trials. Five qualifying grants support this work. Aim 2 is to apply these innovative methods to close the gap between existing research, policy, and practice for HIV prevention. In addition to working closely with our five qualifying grants, we work locally with municipal Departments of Public Health and the federal Substance Abuse and Mental Health Services Administration (SAMHSA) HIV programs to identify and prioritize gaps in knowledge, find optimal implementation strategies for reduction of HIV transmission, and design the next large implementation trials. Aim 3 is to disseminate methods and train/mentor leaders at the intersection of HIV prevention, implementation science, and drug abuse fields to improve implementation of HIV prevention programs. This involves mentoring the early career researchers, publishing, and providing training to networks of HIV and drug abuse researchers.

项目总结/摘要 此申请是为了预防中心实施方法的竞争性更新 艾滋病毒和药物滥用，NIDA P30卓越中心。美国新增艾滋病病例数 仍然稳定在每年56 000人，并继续不成比例地影响一些群体，包括年轻人， 男男性行为者（YMSM），特别是来自少数种族/民族的男性。这样做的目的 方法中心的任务是开发新的方法，供联邦和地方机构使用， 社区减少艾滋病发病率。生物医学干预措施和战略，包括接触前 预防措施（PrEP）、艾滋病毒快速检测以及对艾滋病毒感染者的早期和持续治疗 积极的（治疗即预防，TasP）已被证明具有高疗效和有效性， 减少艾滋病毒的传播，但在研究所知和服务之间仍然存在巨大差距。 需要降低艾滋病毒的人口发病率。本申请的大前提是， 目前正在采取有效生物医学措施，减少艾滋病毒的发病率和差距，但只有 当它们以满足个人、社区和卫生保健提供的方式实施时， 系统需要。该方法提案通过以下方式解决了研究与实践之间的这一重大差距： 执行科学和方法，重点是创新方法，以解决复杂的， 有效实施艾滋病预防计划所需的多层次互动。两个核心， 艾滋病毒和药物滥用问题行政核心和创新执行方法核心将开展 这项工作 目标1是开发创新方法，以最大限度地发挥实施研究的影响， 预防艾滋病毒。我们通过一套扩展的系统科学和工程方法来做到这一点， 重点是改进实施的衡量、实施战略的建模以及 通过严格的试验来检验执行战略。五个合格的赠款支持这项工作。 目标2是应用这些创新方法来缩小现有研究、政策和 预防艾滋病毒的做法。除了与我们的五个合格的赠款密切合作，我们在当地与 市公共卫生部和联邦药物滥用和精神卫生部 服务管理局（SAMHSA）的艾滋病毒方案，以确定和优先考虑知识的差距， 找到减少艾滋病毒传播的最佳实施战略，并设计下一个大规模的 执行试验。 目标3是传播艾滋病毒交叉领域的方法并培训/指导领导人 预防、实施科学和药物滥用领域，以改进艾滋病毒预防工作的实施 程序.这包括指导早期职业研究人员，出版和提供网络培训 艾滋病和药物滥用研究人员的研究。