The Persistence of Longevity Across Generations: An Exploratory Investigation of Grandchildren of ex-POWs

世代相传的长寿：对前战俘孙辈的探索性调查

• 批准号: 9976426
• 负责人: DORA L COSTA
• 金额: $ 20.25万
• 依托单位: NATIONAL BUREAU OF ECONOMIC RESEARCH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-15 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9976426
• 关键词: Adult; Affect; Age; Aging; Animals; Biological Factors; Birth; Brothers; Caring; Cessation of life; Child; Child Health; Data; Databases; Daughter; Dietary Supplementation; Documentation; Environment; Epigenetic Process; Exercise; Exposure to; Family; Famines; Funding; Future Generations; Generations; Genetic; Grant; Health; Health Status; Human; Imprisonment; Infection; Intervention; Investigation; Investments; Life; Link; Longevity; Maternal Exposure; Metabolic; Outcome; Pattern; Personal Satisfaction; Population; Pregnancy; Process; Psychological Stress; Records; Research Personnel; Sampling; Socioeconomic Status; Son; Stress; Trauma; Veterans; War; grandparent; intergenerational; male; psychologic; sex; transmission process; user-friendly

OTHER PROJECT INFORMATION – Project Summary/Abstract The Persistence of Longevity Across Generations: An Exploratory Investigation of Grandchildren of ex-POWs The overarching purpose of this project is to investigate whether there is any evidence for the transmission of ancestral paternal trauma to grandchildren. There is growing concern that health can be transmitted across generations, leading to the persistence of poor health and socioeconomic status within families. Maternal exposure to famines, infection, and psychological stress during pregnancy has been linked to poor health of children at birth and in adulthood, but studies of the intergenerational transmission of paternal health in human populations are few. The findings from this project will provide “proof of concept” for the transmission of paternal trauma in a human population and determine whether further studies are needed in a larger population, whether additional information should be collected to elucidate the mechanisms of any potential transmission, whether future generations should be followed, and, if so, which descendants should be followed. This project will study the transmission of paternal ex-POW status to children of Union Army veterans of the US Civil War (1861-5). It will build on a subsample of a previously NIA funded database that has collected the records of more than 53,000 children of 1,999 Union Army ex-POW and 8,500 non-POW veterans (“Early Indicators, Intergenerational Processes, and Aging,” NIA grant P01AG10120, PI: Costa). Data limitations preclude similar studies in more recent populations. The project will investigate whether ancestral paternal ex-POW trauma is transmitted to the grandchildren of veterans to affect their longevity and whether this transmission is sex-specific. Identification will come from a comparison of grandchildren of ex-POWs when camp conditions were at their worst, ex-POWs when camp conditions were better, and non-POWs. The analysis will require obtaining death information for the granddaughters and grandsons of Union Army veterans, with an over-sample of grandchildren of ex-POWs. The analytical sample will consist of the records of more than 23,000 granddaughters and grandsons who survived to age 45 and who were born after the war to 2,847 veterans. Studying the effects of ancestral exposures will increase our understanding of the health and well-being of descendants and can inform health interventions.

其他项目信息-项目概要/摘要 长寿的世代延续性：对老年人孙辈的探索性调查 前战俘 该项目的首要目的是调查是否有任何证据表明， 对孙子孙女的影响越来越多的人担心健康可以通过 这导致家庭中健康状况和社会经济地位持续不佳。产妇 怀孕期间遭受饥荒、感染和心理压力与妇女的健康状况不佳有关。 出生时和成年时的儿童，但人类父亲健康的代际传递研究 人口很少。该项目的研究结果将为传播 父亲的创伤在人群中，并确定是否需要进一步的研究，在更大的 人群，是否应收集额外的信息，以阐明任何潜在的机制， 传播，后代是否应该遵循，如果是，哪些后代应该 跟踪了 该项目将研究父亲的前战俘身份的传递给联合军退伍军人的子女， 美国内战（1861- 1865）。它将建立在以前NIA资助的数据库的子样本上，该数据库收集了 超过53，000名1，999名联邦军前战俘和8，500名非战俘退伍军人的子女的记录（“早期 指标，代际过程和老龄化，”NIA资助P01 AG 10120，PI：科斯塔）。数据限制 排除了在更近的人群中进行类似的研究。 该项目将调查祖先父亲的前战俘创伤是否会遗传给孙子孙女， 退伍军人影响他们的寿命，以及这种传播是否是性别特异性的。身份将来自 比较前战俘的孙子时，营地条件最差，前战俘时，营地 条件更好，非战俘。分析将需要获得死亡信息， 联邦军老兵的孙女和孙子，以及前战俘的孙子。 分析样本将包括23,000多名孙女和孙子的记录， 幸存到45岁，战后出生的2，847名退伍军人。 研究祖先暴露的影响将增加我们对人类健康和福祉的理解。 后代，并可以为健康干预提供信息。