UAB Diabetes Research Center

该提案将继续2008年首次成立的UAB DRC的进展。我们的使命是：“减轻 糖尿病和心脏代谢疾病造成的痛苦和社会负担， 多学科，基础和转化研究和研究培训，促进对 疾病机制、预防和治疗”。9年来，DRC激发了UAB的研究 社区围绕糖尿病的研究，导致成员增加了69%，从115人增加到194人， 积极的校外糖尿病研究经费增加到每年直接费用总额62 427 510美元。我们 该中心的目标是促进糖尿病研究的卓越，进一步培养有凝聚力的知识分子， 社区促进合作和创新，并为培训和 职业发展。我们的研究强调糖尿病作为一种代谢和血管疾病的研究 并包括卓越的研究领域，包括分子信号，胰岛生物学和自身免疫， 综合代谢血管疾病/炎症，糖尿病并发症，遗传学和流行病学，以及 干预措施和社区研究。我们的具体目标是： 1.通过赞助我们明确要求的研究核心设施，促进和加强糖尿病研究。 以研究人员为基础，涵盖广泛的翻译范围：生物分析REDOX生物学，动物 生理学，人类生理学，干预和翻译核心。 2.通过一个强调创新的试点和可行性资助计划来加强糖尿病研究， 翻译，以及非常有前途的初级调查员的职业发展。 3.赞助一个综合的丰富计划，促进一个有凝聚力的环境，为杰出的 多学科调查员基地，这将加强学习，协作，合议和创新。 4.强调研究，培训和推广，是响应我们的学员的需求，实现 为我们的患者带来更好的结果，并减轻我们社区和国家的糖尿病负担。 5.响应我们调查人员不断变化的需求，并通过领导力推动新的想法， 调查路线，并利用UAB领导层的决心，实质性的机构承诺， 慷慨的慈善事业，从我们的社会，以进一步推动发展的卓越中心， 糖尿病研究在南方腹地的心脏卓越。 DRC对UAB的糖尿病研究卓越产生了显著的影响， 美国糖尿病发病率最高，并围绕共同主题联合研究人员研究糖尿病 在心脏代谢疾病的背景下。我们有信心，将实现进一步的发展和增长 在未来五年内。

This proposal will continue progress of the UAB DRC first established in 2008. Our mission is: “Alleviate suffering and the social burden caused by diabetes and cardiometabolic disease through innovative, multidisciplinary, basic and translational research and research training, which advances understanding of disease mechanisms, prevention, and treatment”. Over 9 years, the DRC has galvanized the UAB research community around the study of diabetes resulting in increased membership by 69% from 115 to 194 and an increase in active extramural diabetes research funding to a total of $62,427,510 annual direct costs. Our center’s goals are to facilitate excellence in diabetes research, further develop a cohesive intellectual community promoting collaboration and innovation, and provide an outstanding environment for training and career development. Our research emphasizes the study of diabetes as both a metabolic and vascular disease and includes areas of research excellence including molecular signaling, islet biology & autoimmunity, integrative metabolism vascular disease/inflammation, diabetes complications, genetics & epidemiology, and interventions & community based research. Our specific aims are to: 1. Facilitate and enhance diabetes research by sponsoring research core facilities expressly required by our investigator base and that cover a broad translational spectrum: Bioanalytical REDOX Biology, Animal Physiology, Human Physiology, and Interventions & Translation Cores. 2. Augment diabetes research via a pilot & feasibility grant program that will emphasize innovation, translation, and career development of highly promising junior investigators. 3. Sponsor an integrated Enrichment Program that promotes a cohesive environment for an outstanding multi-disciplinary investigator base, which will enhance learning, collaboration, collegiality, and innovation. 4. Emphasize research, training, and outreach that are responsive to the needs of our trainees, achieve better outcomes for our patients, and lessen the high burden of diabetes in our community and nation. 5. Respond to the evolving needs of our investigators and through leadership that impels new ideas and lines of investigation, and leverage the resolve of UAB leadership, substantial institutional commitments, and generous philanthropy from our community to further impel the development of a pre-eminent center of diabetes research excellence in the heart of the Deep South. The DRC has exerted a pronounced impact on diabetes research excellence at UAB in a community with the highest rates of diabetes in the US, and has united investigators around common themes to study diabetes in the context of cardiometabolic disease. We are confident that further evolution and growth will be achieved over the next 5 years.