UAB Diabetes Research Center

这项提议将继续推进2008年首次成立的UAB刚果民主共和国的进程。我们的使命是：“缓解 糖尿病和心脏代谢性疾病带来的痛苦和社会负担， 多学科、基础和转化性研究和研究培训，这有助于加深对 疾病机制、预防和治疗“。14年来，刚果民主共和国推动了UAB的研究 围绕糖尿病研究的努力，并建立了一个优秀的研究社区，现已发展到150个 科学研究人员目前的校外糖尿病研究经费每年直接费用为91,388,610美元。我们的 中心的目标是促进糖尿病研究的卓越，进一步发展一个有凝聚力的智力社区 促进协作和创新，为培训和职业生涯提供良好的环境 发展。我们的研究强调糖尿病既是一种代谢性疾病，也是一种血管疾病 包括卓越的研究领域，包括分子信号、胰岛生物学和自身免疫、综合 代谢、血管疾病/炎症、糖尿病并发症、遗传学和流行病学以及干预措施 &基于社区的研究。我们的具体目标是： 1.通过资助下列明确要求的研究核心设施，促进和加强糖尿病研究 我们的研究人员基础涵盖了广泛的翻译范围：动物生理学、人类生理学和 干预与翻译核心。 2.通过一项强调创新的试点和可行性拨款计划，加强糖尿病研究。 翻译，以及非常有前途的初级调查人员的职业发展。 3.发起一项综合充实计划，为杰出的 多学科调查员基础，这将加强学习、培训、协作、合作和 创新。 4.强调研究和拓展，以满足学员的需求，取得更好的成果 为我们的患者带来更好的结果，并减轻我们社区和国家的糖尿病沉重负担。 5.响应我们调查人员不断变化的需求，并通过推动新想法和 调查路线，并利用UAB领导层的决心、实质性的机构承诺以及 来自我们社区的慷慨慈善事业，进一步推动一个卓越的糖尿病中心的发展 在南方腹地的卓越研究。 DRC对UAB在糖尿病研究方面的卓越表现产生了显著影响 糖尿病发病率在美国最高，并已联合调查人员围绕共同主题研究糖尿病 心脏代谢性疾病的背景。我们有信心实现更大的发展和增长。 接下来的5年。

This proposal will continue progress of the UAB DRC first established in 2008. Our mission is: “Alleviate suffering and the social burden caused by diabetes and cardiometabolic disease through innovative, multidisciplinary, basic and translational research and research training, which advances understanding of disease mechanisms, prevention, and treatment”. Over 14 years, the DRC has galvanized the UAB research efforts around the study of diabetes and established an outstanding research community that has grown to 150 scientific investigators with current extramural diabetes research funding of $91,388,610 annual direct costs. Our center’s goals are to facilitate excellence in diabetes research, further develop a cohesive intellectual community promoting collaboration and innovation, and provide an outstanding environment for training and career development. Our research emphasizes the study of diabetes as both a metabolic and vascular disease and includes areas of research excellence including molecular signaling, islet biology & autoimmunity, integrative metabolism, vascular disease/inflammation, diabetes complications, genetics & epidemiology, and interventions & community based research. Our specific aims are to: 1. Facilitate and enhance diabetes research by sponsoring research core facilities expressly required by our investigator base and that cover a broad translational spectrum: Animal Physiology, Human Physiology, and Interventions & Translation Cores. 2. Augment diabetes research via a pilot & feasibility grant program that will emphasize innovation, translation, and career development of highly promising junior investigators. 3. Sponsor an integrated Enrichment Program that promotes a cohesive environment for an outstanding multi-disciplinary investigator base, which will enhance learning, training, collaboration, collegiality, and innovation. 4. Emphasize research and outreach that are responsive to the needs of our trainees, achieve better outcomes for our patients, and lessen the high burden of diabetes in our community and nation. 5. Respond to the evolving needs of our investigators and through leadership that impels new ideas and lines of investigation, and leverage the resolve of UAB leadership, substantial institutional commitments, and generous philanthropy from our community to further impel the development of a pre-eminent center of diabetes research excellence in the heart of the Deep South. The DRC has exerted a pronounced impact on diabetes research excellence at UAB in a community with the highest rates of diabetes in the US, and has united investigators around common themes to study diabetes in the context of cardiometabolic disease. We are confident that further evolution and growth will be achieved over the next 5 years.