Epigenome modification by a dietary pattern rich in polyunsaturated fatty acids
富含多不饱和脂肪酸的饮食模式改变表观基因组
基本信息
- 批准号:9977788
- 负责人:
- 金额:$ 14.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-07-15 至 2023-03-31
- 项目状态:已结题
- 来源:
- 关键词:AdherenceAlaska NativeBehavioralBiologicalBiological MarkersBody WeightC-reactive proteinCandidate Disease GeneCarbohydratesCardiovascular DiseasesCollaborationsCommunitiesConsumptionDNADNA MethylationDataDevelopmentDietDietary PracticesDietary intakeDocosahexaenoic AcidsEatingEicosapentaenoic AcidEnvironmental ExposureEpigenetic ProcessEvaluationExhibitsFatty acid glycerol estersFishesFoodGene ExpressionGene Expression ProfilingGene-ModifiedGeneral PopulationGenesGeneticGenetic Predisposition to DiseaseGenetic RiskGenetic TranscriptionGenetic VariationGenomic DNAGoalsHealthHealth Care CostsHeritabilityIndividualInsulinIntakeInuitsLeptinLinkLipidsMammalsMapsMeasuresMediatingMetabolicMetabolic DiseasesMetabolic syndromeMethylationModificationMolecularMorbidity - disease rateN-3 polyunsaturated fatty acidNative-BornNitrogenNon-Insulin-Dependent Diabetes MellitusObesityOverweightParticipantPathway interactionsPhenotypePlayPolyunsaturated Fatty AcidsPopulationPositioning AttributePrevalenceProcessProteinsPublishingRNAReportingResearchRisk FactorsRoleSample SizeSamplingSiteSuggestionTestingTimeTriglyceridesVitamin AVitamin DWorkYup&aposikadiponectinbasebiobankbisulfite sequencingcardioprotectioncohortepigenetic markerepigenetic variationepigenomeepigenome-wide association studiesepigenomicsexperiencegenetic variantglobal healthinflammatory markerinsightinsulin sensitivitymetabolic profilemethylation biomarkermethylation patternmortalityperipheral bloodpreventprotein intakescreeningstable isotope
项目摘要
Revised Project Summary/Abstract
The overall goal of the proposed research is to identify epigenetic changes in biological pathways associated with protection from Type 2 Diabetes (T2D) in Yup’ik Alaska Native people consuming a traditional diet. The Yup’ik traditional dietary pattern is characterized by high protein, high fat, and low carbohydrate intakes, as well as n-3 polyunsaturated fatty acid levels that are up to 20 times higher than in the general U.S. population. High levels of traditional food intake in Yup’ik people are positively associated with adiponectin and inversely associated with c-reactive protein, triglycerides, and the leptin:adiponectin ratio, suggestive of increased insulin sensitivity. However, the diet of Yup’ik people is transitioning to increased consumption of highly processed market foods, and the prevalence of overweight and obesity is beginning to mirror that of the general U.S. population. Even so, the prevalence of metabolic syndrome (15%) and T2D (3%) among Yup’ik people remains lower than in the general U.S. population. Adherence to a Yup’ik traditional dietary pattern is likely to be protective in Yup’ik people, although the mechanisms of protection are not well understood. We will use the nitrogen stable isotope ratio (δ15N) as a validated, objective measure of the traditional dietary pattern to explore these mechanisms.
Although considerable advances have been made in the identification of genetic factors contributing to metabolic diseases, less than 10% of the heritability of T2D phenotypes is explained by known genetic variation. Epigenetic mechanisms have recently been proposed as a link between genetic risk and environmental exposures such as diet, thereby providing a mechanism for the modification of genetic predisposition and insight into 90% of the heritability that is not explained. The proposed research will fine map epigenetic biomarkers in the 20 most promising candidate genes identified using Illumina MethylationEPIC microarrays on stored peripheral blood DNA samples from 569 Yup’ik people at the highest and lowest deciles of traditional dietary intake (DK104347) using targeted bisulfite sequencing to reveal detailed DNA methylation patterns not apparent in the array data, and to identify genetic variants that influence methylation at these genes. These findings will be replicated in a Greenlandic Inuit cohort to determine the generalizability of the findings from Yup’ik people. The downstream functional consequences of methylation patterns in the candidate genes will be assessed using gene expression assays in 192 peripheral blood RNA samples from individuals at the extremes of the distribution of our dietary measure, δ15N. By identifying epigenomic biomarkers associated both with adherence to a traditional diet and with insulin sensitivity, the proposed research will test the hypothesis that a traditional Yup’ik diet modifies the downstream transcription of key genes that contribute to metabolic health of Yup’ik people.
修订后的项目摘要/摘要
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Diet quality is positively associated with intake of traditional foods and does not differ by season in remote Yup'ik communities.
在偏远的尤皮克社区,饮食质量与传统食物的摄入量呈正相关,并且不随季节而变化。
- DOI:10.1080/22423982.2023.2221370
- 发表时间:2023-12
- 期刊:
- 影响因子:1.3
- 作者:Hill, Courtney M.;Nash, Sarah H.;Hopkins, Scarlett E.;Boyer, Bert B.;OBrien, Diane M.;Bersamin, Andrea
- 通讯作者:Bersamin, Andrea
Corrigendum to 'Habitual Intake of Marine-Derived n-3 PUFAs is Inversely Associated with a Cardiometabolic Inflammatory Profile in Yup'ik Alaska Native People' [J Nutrition 2022 Mar 3;152(3):844-855].
“习惯性摄入海洋来源的 n-3 PUFA 与尤皮克阿拉斯加原住民的心脏代谢炎症呈负相关”[J Nutrition 2022 Mar 3;152(3):844-855]。
- DOI:10.1016/j.tjnut.2023.04.005
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Boyer,BertB;Hopkins,ScarlettE;Wiener,HowardW;Purnell,JonathanQ;O'Brien,DianeM;Zhang,CindyX;Aslan,JosephE;Aliwarga,Theresa;Pomeroy,JeremyJ;Thummel,KennethE;Tiwari,HemantK
- 通讯作者:Tiwari,HemantK
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Devin Michael Absher其他文献
Devin Michael Absher的其他文献
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{{ truncateString('Devin Michael Absher', 18)}}的其他基金
Epigenome modification by a dietary pattern rich in polyunsaturated fatty acids
富含多不饱和脂肪酸的饮食模式改变表观基因组
- 批准号:
9246287 - 财政年份:2017
- 资助金额:
$ 14.97万 - 项目类别:
Epigenome modification by a dietary pattern rich in polyunsaturated fatty acids
富含多不饱和脂肪酸的饮食模式改变表观基因组
- 批准号:
9766282 - 财政年份:2017
- 资助金额:
$ 14.97万 - 项目类别:
Epigenome modification by a dietary pattern rich in polyunsaturated fatty acids
富含多不饱和脂肪酸的饮食模式改变表观基因组
- 批准号:
9037551 - 财政年份:2016
- 资助金额:
$ 14.97万 - 项目类别:
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