Urothelial Stem Cells
尿路上皮干细胞
基本信息
- 批准号:9978775
- 负责人:
- 金额:$ 54.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-01 至 2023-06-30
- 项目状态:已结题
- 来源:
- 关键词:AdultAttentionBiological ProcessBladderBladder DiseasesBladder UrotheliumCell LineageCell SeparationCellsCorneaDiagnosisDiseaseEngineered GeneEpidermisEpithelialEpitheliumGoalsGrowthHarvestHomeostasisIn VitroInfectionInterstitial CystitisLabelLeadLigandsLocationMesenchymeMetaplasiaMolecularNatural regenerationOrganPathway interactionsPatternPlayPrincipal InvestigatorPropertyRegulationRenal pelvisRestRoleSiteStratum BasaleTissue EngineeringTissuesUreterUrethraUrinary tractUrinary tract infectionUrothelial CellUrotheliumWorkbasebeta catenincorneal epitheliumexperiencegene therapyimprovedin vivokeratinocytelimbalmigrationmolecular markernovelprogenitorrepairedstem cellstissue repairtumorigenesisureteric orificeurothelial injurywound healing
项目摘要
Summary
This project builds upon the Principal Investigator’s extensive experience in studying urothelial
differentiation and keratinocyte stem cells, and aims at providing a better understanding of bladder
urothelial stem cells. Despite the central importance of urothelial stem cells in the homeostasis,
regeneration and tumorigenesis of the bladder, their precise location and properties are still
incompletely understood. There are several issues that hinder the progress in this field. For example,
since the term “urothelium” is used to describe the uroplakin-expressing epithelium that covers the
entire urinary tract including the renal pelvis, ureter, bladder and proximal urethra, it is often assumed
that urothelia of all these sites are the same. In addition, studies on bladder urothelial stem cells have
been limited to the bladder per se and no attention has been paid to urothelial stem cells outside of
the bladder proper. However, we have recently discovered that ureterovesicular junction (UVJ)
harbors a large cluster of strongly labeled (label-retaining) stem cells. The presence of a major cluster
of stem cells outside of the bladder proper, located near the bladder-ureter orifice, is reminiscent of
the corneal epithelium whose stem cells reside outside of the corneal proper in the limbal zone, and
the follicular bulge stem cells that, although outside of the epidermis, are involved in epidermal repair.
The goals of this project are to better understand the properties and in vivo functions of the UVJ stem
cells, and their relationships with the bladder and ureteral urothelial stem cells. These studies can
improve our understanding of urothelial homeostasis, regeneration, and diseases including
metaplasia and urinary tract infection. To reach these goals, we will pursue three Specific Aims that
will study: (i) molecular markers of urothelial lineages and stem cells, (ii) biological functions of the
urothelial stem cells, and (iii) the possible roles of the Wnt pathway in regulating the urothelial stem
cells.
概括
该项目建立在首席研究员研究尿路上皮的丰富经验的基础上
分化和角质形成细胞干细胞,旨在提供对膀胱更好的了解
尿路上皮干细胞。尽管尿路上皮干细胞在体内平衡中具有核心重要性,
膀胱的再生和肿瘤发生,其精确位置和特性仍然未知
不完全理解。有几个问题阻碍了这一领域的进展。例如,
因为术语“尿路上皮”用于描述表达尿斑蛋白的上皮,覆盖
整个泌尿道,包括肾盂、输尿管、膀胱和近端尿道,通常认为
所有这些部位的尿路上皮都是相同的。此外,对膀胱尿路上皮干细胞的研究
仅限于膀胱本身,并且没有关注膀胱以外的尿路上皮干细胞
膀胱本身。然而,我们最近发现输尿管膀胱连接处(UVJ)
拥有一大群强标记(标记保留)干细胞。主要集群的存在
膀胱本身外部的干细胞位于膀胱输尿管口附近,让人想起
角膜上皮,其干细胞位于角膜本身之外的角膜缘区,以及
毛囊隆起干细胞虽然位于表皮之外,但参与表皮修复。
该项目的目标是更好地了解 UVJ 干的特性和体内功能
细胞及其与膀胱和输尿管尿路上皮干细胞的关系。这些研究可以
提高我们对尿路上皮稳态、再生和疾病的理解,包括
化生和尿路感染。为了实现这些目标,我们将追求三个具体目标:
将研究:(i) 尿路上皮谱系和干细胞的分子标记,(ii) 尿路上皮谱系和干细胞的生物学功能
尿路上皮干细胞,以及 (iii) Wnt 通路在调节尿路上皮干中的可能作用
细胞。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
XUE-RU WU其他文献
XUE-RU WU的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('XUE-RU WU', 18)}}的其他基金
BCCMA: Basic and Translational Mechanisms of Cancer Initiation of the Urothelium in Veterans Exposed to Carcinogens: Role of PPARg in theFormation and Progression of Carcinoma in situ of the Bladder
BCCMA:暴露于致癌物的退伍军人尿路上皮癌症发生的基本和转化机制:PPARg 在膀胱原位癌形成和进展中的作用
- 批准号:
10361590 - 财政年份:2022
- 资助金额:
$ 54.52万 - 项目类别:
BCCMA: Basic and Translational Mechanisms of Cancer Initiation of the Urothelium in Veterans Exposed to Carcinogens: Role of PPARg in theFormation and Progression of Carcinoma in situ of the Bladder
BCCMA:暴露于致癌物的退伍军人尿路上皮癌症发生的基本和转化机制:PPARg 在膀胱原位癌形成和进展中的作用
- 批准号:
10616472 - 财政年份:2022
- 资助金额:
$ 54.52万 - 项目类别:
Role of Tamm-Horsfall Protein in Urinary Tract Defense
Tamm-Horsfall 蛋白在尿路防御中的作用
- 批准号:
8785878 - 财政年份:2014
- 资助金额:
$ 54.52万 - 项目类别:
Molecular and Genetic Studies of Bladder Tumorigenesis
膀胱肿瘤发生的分子和遗传学研究
- 批准号:
10427138 - 财政年份:2013
- 资助金额:
$ 54.52万 - 项目类别:
相似国自然基金
多模态超声VisTran-Attention网络评估早期子宫颈癌保留生育功能手术可行性
- 批准号:
- 批准年份:2022
- 资助金额:30 万元
- 项目类别:青年科学基金项目
Ultrasomics-Attention孪生网络早期精准评估肝内胆管癌免疫治疗的研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
相似海外基金
Development of social attention indicators of emerging technologies and science policies with network analysis and text mining
利用网络分析和文本挖掘开发新兴技术和科学政策的社会关注指标
- 批准号:
24K16438 - 财政年份:2024
- 资助金额:
$ 54.52万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Improving Flexible Attention to Numerical and Spatial Magnitudes in Young Children
提高幼儿对数字和空间大小的灵活注意力
- 批准号:
2410889 - 财政年份:2024
- 资助金额:
$ 54.52万 - 项目类别:
Continuing Grant
The Information-Attention Tradeoff: Toward an Understanding of the Fundamentals of Online Attention
信息与注意力的权衡:了解在线注意力的基本原理
- 批准号:
2343858 - 财政年份:2024
- 资助金额:
$ 54.52万 - 项目类别:
Continuing Grant
The everyday learning opportunities of young children with attention and motor difficulties: From understanding constraints to reshaping intervention
注意力和运动困难幼儿的日常学习机会:从理解限制到重塑干预
- 批准号:
MR/X032922/1 - 财政年份:2024
- 资助金额:
$ 54.52万 - 项目类别:
Fellowship
Towards a cognitive process model of how attention and choice interact
建立注意力和选择如何相互作用的认知过程模型
- 批准号:
DP240102605 - 财政年份:2024
- 资助金额:
$ 54.52万 - 项目类别:
Discovery Projects
DDRIG in DRMS: Communicating risks in a sensational media environment-Using short video multimodal features to attract attention and reduce psychological reactance for persuasion
DRMS中的DDRIG:耸人听闻的媒体环境中沟通风险——利用短视频多模态特征吸引注意力,减少说服心理抵触
- 批准号:
2343506 - 财政年份:2024
- 资助金额:
$ 54.52万 - 项目类别:
Standard Grant
Assessing the Influence of Reading Fiction on Multiple Tests of Attention
评估阅读小说对注意力多重测试的影响
- 批准号:
24K16033 - 财政年份:2024
- 资助金额:
$ 54.52万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
CAREER: Designing Ultra-Energy-Efficient Intelligent Hardware with On-Chip Learning, Attention, and Inference
职业:设计具有片上学习、注意力和推理功能的超节能智能硬件
- 批准号:
2336012 - 财政年份:2023
- 资助金额:
$ 54.52万 - 项目类别:
Continuing Grant
CPS: Small: Brain-Inspired Memorization and Attention for Intelligent Sensing
CPS:小:智能传感的受大脑启发的记忆和注意力
- 批准号:
2312517 - 财政年份:2023
- 资助金额:
$ 54.52万 - 项目类别:
Standard Grant
CAREER: Understanding the Relationship of Covert and Overt Attention Using Concurrent EEG and Eye Tracking
职业:使用并发脑电图和眼动追踪了解隐性注意力和显性注意力的关系
- 批准号:
2345898 - 财政年份:2023
- 资助金额:
$ 54.52万 - 项目类别:
Continuing Grant