ApoJ as a novel hepatokine targeting muscle glucose metabolism

ApoJ 作为一种靶向肌肉葡萄糖代谢的新型肝因子

基本信息

  • 批准号:
    9978058
  • 负责人:
  • 金额:
    $ 43.25万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-09-20 至 2022-07-31
  • 项目状态:
    已结题

项目摘要

A major challenge in the field of metabolic physiology has been to understand the interorgan communication networks linking to glucose metabolism. One critical factor for this interorgan system is now known as hepatokines, identified from liver-derived proteins, and that play a pivotal role in regulating glucose metabolism and insulin sensitivity in skeletal muscle. ApoJ (apolipoprotienJ, also called clusterin) was not previously suspected to be involved in the regulation of glucose homeostasis and insulin signaling. Our preliminary data demonstrate that ApoJ may function as a hepatokine targeting insulin signaling and glucose metabolism in skeletal muscle, which could be mediated via the LRP1/2 (low-density lipoprotein receptor-related protein-1/2) signaling cascade. We thus hypothesize that the ApoJ → LRP1/2 axis is a novel metabolic signaling network that is crucial for the maintenance of normal glucose homeostasis and insulin signaling and that this couples with the insulin receptor system. The overall objective of this proposal is to identify ApoJ as a novel hepatokine that controls muscle glucose homeostasis via LRP1/2 signaling coupled with the insulin receptor system. Specifically, Aim1 will establish the biological function of ApoJ as a new hepatokine in glucose metabolism. Aim2 will determine whether the ApoJ → LRP1/2 signaling pathway is a key component of insulin action in skeletal muscle. Aim3 will elucidate the cellular mechanisms for the insulin-sensitizing effects of ApoJ. To accomplish these aims, we will use state-of-the-art technologies, including a conditional floxed ApoJ, LRP1 and LRP2 models as well as human subjects to clarify the metabolic function of the ApoJ → LRP2 axis in the context of interorgan communication networks. These studies provide a unique opportunity to establish a new paradigm in which the ApoJ → LRP2 signaling network is a key determinant of glucose homeostasis, and may offer a novel target for the treatment of obesity and diabetes.
代谢生理学领域的一个主要挑战是理解器官间的关系

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Urine clusterin/apolipoprotein J is linked to tubular damage and renal outcomes in patients with type 2 diabetes mellitus.
  • DOI:
    10.1111/cen.13360
  • 发表时间:
    2017-08
  • 期刊:
  • 影响因子:
    3.2
  • 作者:
    Kim SS;Song SH;Kim JH;Jeon YK;Kim BH;Kang MC;Chun SW;Hong SH;Chung M;Kim YK;Kim IJ;Kim YB
  • 通讯作者:
    Kim YB
TET2: Is a potential gatekeeper for the action of thiazolidinedione in fat cells?
TET2:噻唑烷二酮在脂肪细胞中的作用是否是潜在的看门人?
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

YOUNG-BUM KIM其他文献

YOUNG-BUM KIM的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('YOUNG-BUM KIM', 18)}}的其他基金

Role of LRP1 in Alzheimer’s disease
LRP1 在阿尔茨海默病中的作用
  • 批准号:
    10596290
  • 财政年份:
    2023
  • 资助金额:
    $ 43.25万
  • 项目类别:
Rho-kinase signaling in energy balance
能量平衡中的 Rho 激酶信号传导
  • 批准号:
    10529777
  • 财政年份:
    2022
  • 资助金额:
    $ 43.25万
  • 项目类别:
Rho-kinase signaling in energy balance
能量平衡中的 Rho 激酶信号传导
  • 批准号:
    10659215
  • 财政年份:
    2022
  • 资助金额:
    $ 43.25万
  • 项目类别:
Role of tanycytic LRP in Aβ clearance
tanycytic LRP 在 Aβ 清除中的作用
  • 批准号:
    10281970
  • 财政年份:
    2020
  • 资助金额:
    $ 43.25万
  • 项目类别:
Control of leptin transport system by LRP
LRP 控制瘦素转运系统
  • 批准号:
    10396523
  • 财政年份:
    2020
  • 资助金额:
    $ 43.25万
  • 项目类别:
Control of leptin transport system by LRP
LRP 控制瘦素转运系统
  • 批准号:
    10620359
  • 财政年份:
    2020
  • 资助金额:
    $ 43.25万
  • 项目类别:
Control of Energy Balance by ApoJ Signaling
通过 ApoJ 信号传导控制能量平衡
  • 批准号:
    9977165
  • 财政年份:
    2017
  • 资助金额:
    $ 43.25万
  • 项目类别:
Control of Energy Balance by ApoJ Signaling
通过 ApoJ 信号传导控制能量平衡
  • 批准号:
    10197311
  • 财政年份:
    2017
  • 资助金额:
    $ 43.25万
  • 项目类别:
Control of Energy Balance by ApoJ Signaling
通过 ApoJ 信号传导控制能量平衡
  • 批准号:
    9234692
  • 财政年份:
    2017
  • 资助金额:
    $ 43.25万
  • 项目类别:
Leptin Signaling in Hypothalamic Neurons and Glutamate Receptors
下丘脑神经元和谷氨酸受体中的瘦素信号传导
  • 批准号:
    8661767
  • 财政年份:
    2012
  • 资助金额:
    $ 43.25万
  • 项目类别:

相似海外基金

Nitrous Oxide Management in a Novel Biological Process
新型生物过程中的一氧化二氮管理
  • 批准号:
    2789227
  • 财政年份:
    2023
  • 资助金额:
    $ 43.25万
  • 项目类别:
    Studentship
Dynamic regulation of RNA modification and biological process
RNA修饰和生物过程的动态调控
  • 批准号:
    18H05272
  • 财政年份:
    2018
  • 资助金额:
    $ 43.25万
  • 项目类别:
    Grant-in-Aid for Scientific Research (S)
Micro-Scale Biological Process Automation: Modelling, Sensing and Control
微尺度生物过程自动化:建模、传感和控制
  • 批准号:
    42116-2013
  • 财政年份:
    2017
  • 资助金额:
    $ 43.25万
  • 项目类别:
    Discovery Grants Program - Individual
Micro-Scale Biological Process Automation: Modelling, Sensing and Control
微尺度生物过程自动化:建模、传感和控制
  • 批准号:
    42116-2013
  • 财政年份:
    2016
  • 资助金额:
    $ 43.25万
  • 项目类别:
    Discovery Grants Program - Individual
Organizing the Waterloo Biofilter biological process for treating wastewater concentrated by extreme water conservation plumbing
组织滑铁卢生物过滤器生物工艺处理通过极端节水管道浓缩的废水
  • 批准号:
    479764-2015
  • 财政年份:
    2015
  • 资助金额:
    $ 43.25万
  • 项目类别:
    Engage Grants Program
Micro-Scale Biological Process Automation: Modelling, Sensing and Control
微尺度生物过程自动化:建模、传感和控制
  • 批准号:
    42116-2013
  • 财政年份:
    2015
  • 资助金额:
    $ 43.25万
  • 项目类别:
    Discovery Grants Program - Individual
Development of Biological Process for VOC treatment
VOC处理生物工艺的开发
  • 批准号:
    476672-2014
  • 财政年份:
    2015
  • 资助金额:
    $ 43.25万
  • 项目类别:
    Experience Awards (previously Industrial Undergraduate Student Research Awards)
Micro-Scale Biological Process Automation: Modelling, Sensing and Control
微尺度生物过程自动化:建模、传感和控制
  • 批准号:
    42116-2013
  • 财政年份:
    2014
  • 资助金额:
    $ 43.25万
  • 项目类别:
    Discovery Grants Program - Individual
Optimization of a biological process treating winery wastewater: anaerobic digestion integrated with Waterloo biofilter
处理酿酒厂废水的生物工艺优化:厌氧消化与滑铁卢生物过滤器集成
  • 批准号:
    463193-2014
  • 财政年份:
    2014
  • 资助金额:
    $ 43.25万
  • 项目类别:
    Engage Grants Program
Micro-Scale Biological Process Automation: Modelling, Sensing and Control
微尺度生物过程自动化:建模、传感和控制
  • 批准号:
    42116-2013
  • 财政年份:
    2013
  • 资助金额:
    $ 43.25万
  • 项目类别:
    Discovery Grants Program - Individual
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了