Synthetic Models of the Oxygen Evolving Complex of Photosystem II
光系统II放氧复合物的合成模型
基本信息
- 批准号:9980923
- 负责人:
- 金额:$ 20.94万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-09-01 至 2023-04-30
- 项目状态:已结题
- 来源:
- 关键词:Active SitesAddressAffectAtmosphereBehaviorBenchmarkingBindingBiochemicalBiochemical ReactionBiologicalBiological ModelsBiological ProcessCatalysisChemicalsComplementComplexCyanobacteriumDioxygenElectron Spin Resonance SpectroscopyElectronsGenerationsGoalsHandHumanInvestigationIsotope LabelingLifeLigandsMetalsMethodsMissionModelingNatureOrganismOxidation-ReductionOxygenPhotosynthesisPhysiologic pulsePlanet EarthPlantsProcessProductionPropertyProteinsProtonsRoleRouteSiteSpectrum AnalysisStructural ModelsStructureSystemTechniquesTestingTheoretical StudiesUnited States National Institutes of HealthWaterWorkX ray spectroscopybiological systemschemical propertyelectronic structureexperimental studyinterestmanganese oxidemetal complexmetal oxideoxidationphotosystem IIphysical propertyprotein complexprotonationsmall moleculespectroscopic survey
项目摘要
Abstract
Biological dioxygen generation occurs within Photosystem II (PSII) in cyanobacteria and plants. The
active site responsible for this transformation, the Oxygen Evolving Complex (OEC), consists of a
Mn4CaOn cluster embedded in a large protein complex. This metal cluster is responsible for the
oxygenic atmosphere on Earth, and consequently for most life as we know it. Given the broad
fundamental interest and potential applications of water splitting to make dioxygen, the structure of
this cluster and the mechanism of catalysis have been the subject of many spectroscopic,
computational, synthetic, crystallographic and biochemical studies. Despite significant advances, the
mechanism of oxygen production is still not well understood. The exact Mn oxidation states along the
catalytic cycle and the site of O-O bond formation continue to be debated. The large protein matrix
has complicated direct studies of the OEC active site and the rational synthesis of accurate small-
molecule models suitable for structure-function studies has been hampered by the complexity of the
cluster.
Our goals include developing synthetic routes to MnxMOn models (x=3, 4; M=Ca, Mn, other metals) of
the OEC and its subsites and undertaking mechanistic studies that will allow a deeper understanding
of the effects different constituents (metals, ancillary and oxo ligands, protonation state) have on the
chemical and physical properties of the cluster relevant to achieving high oxidation states and
effecting O2 production. To that end, we will test hypotheses regarding electron, oxygen-atom and
proton transfers and ligand substitution in these complex systems with implications for O-O bond
formation. With few exceptions, the synthesis of predictable manganese oxide clusters has been
frustrated by the propensity of oxo ligands to bridge and form complicated oligomeric structures. Our
approach to overcoming this problem is to use relatively small, but rigid organic frameworks to support
trimanganese complexes that have been elaborated to site-differentiated metal-oxo clusters, including
close structural and functional models of the biological system. These synthetic clusters will allow for
spectroscopic benchmarking (EPR, XES, XAS) in comparison with the biological system. Our work on
synthetic complexes will complement the studies performed on the protein by allowing systematic
structure-property studies to uncover the chemical features that control the reactivity and
spectroscopy of these clusters and the mechanism of catalysis.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Theodor Agapie其他文献
Theodor Agapie的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Theodor Agapie', 18)}}的其他基金
Synthetic Models of the Oxygen Evolving Complex of Photosystem II
光系统II放氧复合物的合成模型
- 批准号:
9278192 - 财政年份:2013
- 资助金额:
$ 20.94万 - 项目类别:
Synthetic Models of the Oxygen Evolving Complex of Photosystem II
光系统II放氧复合物的合成模型
- 批准号:
9066718 - 财政年份:2013
- 资助金额:
$ 20.94万 - 项目类别:
Synthetic Models of the Oxygen Evolving Complex of Photosystem II
光系统II放氧复合物的合成模型
- 批准号:
8724526 - 财政年份:2013
- 资助金额:
$ 20.94万 - 项目类别:
Synthetic Models of the Oxygen Evolving Complex of Photosystem II
光系统II放氧复合物的合成模型
- 批准号:
8506791 - 财政年份:2013
- 资助金额:
$ 20.94万 - 项目类别:
Synthetic Models of the Oxygen Evolving Complex of Photosystem II
光系统II放氧复合物的合成模型
- 批准号:
10393595 - 财政年份:2013
- 资助金额:
$ 20.94万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 20.94万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 20.94万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 20.94万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 20.94万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 20.94万 - 项目类别:
Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 20.94万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 20.94万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 20.94万 - 项目类别:
EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 20.94万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 20.94万 - 项目类别:
Research Grant