Preventing Risky Drinking and PTSD After Sexual Assault: A Web-Based Intervention

拟议的独立之路奖的长期目标是支持申请人 建立一个独立的研究计划，并支持她过渡到一个独立的研究科学家 助理教授的职位广泛地说，她的研究迄今已调查的促进者和障碍， 创伤恢复，重点是这些过程发生的社会背景，她最近 开始研究酒精使用是否是创伤的结果她打算把博士后的研究训练 从理解创伤后饮酒的病因学机制， 以技术为基础的干预措施，以防止创伤后高危饮酒的发展。这些 目标将通过5年培训计划实现，申请人将获得技能， 通过导师制，课程，研讨会， 讲习班和全国会议。研究计划的长期目标是开发一个有效的网络， 基于早期干预策略，以减轻性侵犯女性幸存者的高危饮酒和PTSD (SA)鉴于SA是该人群中特别常见和有害的创伤形式， 与饮酒问题和创伤后应激障碍有关干预措施将调整现有的基于证据的 以符合理论和研究的方式进行实践，通过增加社会 支持和减轻负面社会反应的危害（例如，受害者责任）。K99阶段将涉及 实现具体目标1和2。具体目标1：利用现有的专门知识资源， 为原型干预措施的开发提供信息，将通过咨询现有的临床干预措施来完成 手册，并与社区利益攸关方进行定性访谈和焦点小组， 的幸存者。具体目标2涉及征求幸存者的反馈意见，以告知改善 原型干预的可用性和用户满意度。具体目标3（即，评估参与者的 对干预的反应）和4（即，评估干预措施对学习和症状的影响） 在R00阶段，通过干预的可行性试验，以具有以下特征的妇女为样本， 最近被性侵犯了本研究将为向NIAAA提交的R01申请提供试验数据， R00阶段，将在RCT中测试干预的有效性。凯森医生爱德华兹医生卢医生 Areán将担任该奖项的导师，并提供酒精研究，干预等领域的专业知识。 针对社会支持，随机对照试验，统计和基于技术的干预措施。的 华盛顿大学的培训环境非常有利于培养技能和专业知识 需要转变为酒精研究领域的独立研究科学家， 科技创新拟议的奖项与NIH开发新的独立药物的目标是一致的。 研究人员在他们的内容领域有很强的技能，谁是NIH的资金竞争力。

The long-term objectives of the proposed Pathway to Independence Award are to support the applicant in building an independent program of research, and support her transition into an independent research scientist in an assistant professor position. Broadly, her research to date has investigated facilitators of and barriers to trauma recovery, with a focus on the social contexts in which these processes occur, and she has recently begun examining alcohol use as an outcome of trauma. She intends to shift her postdoctoral research training from understanding mechanisms involved in the etiology of drinking after trauma to the creation and testing of technologically-based interventions to prevent the development of high-risk drinking after trauma. These objectives will be achieved through a 5-year training plan in which the applicant will acquire the skills and expertise necessary to establish her program of research through mentorship, coursework, seminars, workshops, and national conferences. The long-term goal of the research plan is to develop an effective web- based early intervention strategy to mitigate high-risk drinking and PTSD in female survivors of sexual assault (SA), given that SA is a particularly common and deleterious form of trauma in this population that is commonly associated with co-occurring drinking problems and PTSD. The intervention will adapt existing evidence-based practices in a manner consistent with theory and research to target these outcomes by increasing social support and mitigating the harm of negative social reactions (e.g., victim blame). The K99 phase will involve the accomplishment of Specific Aims 1 and 2. Specific Aim 1, which is to use existing sources of expertise to inform the development of a prototype intervention, will be accomplished by consulting existing clinical manuals and conducting qualitative interviews and focus groups with community stakeholders serving survivors of SA. Specific Aim 2 involves eliciting feedback from survivors to inform changes that improve the usability of and user satisfaction with the prototype intervention. Specific Aims 3 (i.e., assess participant reaction to the intervention) and 4 (i.e., assess the impact of the intervention on learning and symptoms) will be accomplished in the R00 phase via a feasibility trial of the intervention with a sample of women who have recently been sexually assaulted. This research will provide pilot data for an R01 submission to NIAAA during the R00 phase which will test the efficacy of the intervention in an RCT. Drs. Kaysen, Edwards, Rhew, and Areán will serve as mentors for this award and offer expertise in the areas of alcohol research, interventions targeting social support, randomized controlled trials, statistics, and technology-based interventions. The University of Washington training environment is highly conducive to developing the skills and expertise needed to transition into a role as an independent research scientist in the area of alcohol research and technological innovation. The proposed award is consistent with NIH's goal of developing new independent investigators with strong skills in their content area who are competitive for NIH funding.