Optically Sensorized, Actuated Needles for Oncological Applications

用于肿瘤学应用的光学传感驱动针

• 批准号: 9984206
• 负责人: Behzad Moslehi
• 金额: $ 2.63万
• 依托单位: INTELLIGENT FIBER OPTIC SYSTEMS CORP
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-26 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9984206
• 关键词: Ablation; Anatomy; Animals; Biopsy; Body part; Caliber; Clinical; Development; Devices; Drug Delivery Systems; Effectiveness; Ensure; Fiber; Fiber Optics; Freedom; Human; Image; Imaging technology; In Situ; Intelligence; Intervention; Interview; Intuition; Lasers; Liver; Magnetic Resonance Imaging; Measurement; Methods; Motor; Needle biopsy procedure; Needles; Obstruction; Organ; Patients; Phase; Procedures; Property; Prostate; Protocols documentation; Reaction; Rotation; Route; Series; Small Business Innovation Research Grant; System; Tendon structure; Testing; Texas; Time; Tissues; Universities; Work; base; clinical application; commercialization; design; dexterity; experimental study; improved; in vivo; innovation; kidney biopsy; minimally invasive; optical sensor

Optically Sensorized, Actuated Needles for Oncological Applications Intelligent Fiber Optic Systems Corporation (IFOS) 2363 Calle del Mundo, Santa Clara, CA 95054-1008 www.ifos.com PROJECT SUMMARY/ABSTRACT (MAXIMUM 30 LINES) In this Direct-to-Phase-II SBIR application, IFOS and Texas A&M University propose to develop and validate an actively steered, tendon-actuated, small-caliber needle for precise imaging-assisted percutaneous procedures with focus on deep tissue biopsies. Interviews with clinicians have confirmed that steering capability would greatly improve clinical methods for biopsy and drug delivery. With current methods, precise needle placement is not always possible in procedures targeting deep tissue, where routes of entry are restricted due to anatomical obstructions and the need to avoid vital organs. Furthermore, as the needle is inserted, forces from the surrounding tissue cause the needle to deflect off the planned path. Such deviations result in multiple reinsertions, adding to patient discomfort and procedure time, and compromising the effectiveness of minimally invasive procedures. The proposed active steering can compensate for deflection encountered during insertion, which becomes increasingly significant as the path to the target lengthens. The active steering concept is based on linear servo motors that actuate needle tip flexion through connected tendon fibers. The design feature of a hollow NiTi needle allows for applications like drug delivery and laser ablation when another needle is inserted within the host needle core. This design also incorporates a removable core with attached fiber Bragg gratings to sense obstructing internal body parts, reducing the need for assistive MR imaging during the procedure. Imaging technologies are still options if the operator wants to view these obstructions during the procedure, since the needle itself is MRI compatible. In prior work, bending rates of over 2 degrees per second have been repeatably achieved in phantoms that mimic the properties of human prostate tissue, and, we have implemented a thinner needle design, an intuitive console design concept, and a closed-loop control system that enables real-time needle curvature and in situ tissue reaction force measurements. The initial effort is designed to demonstrate still greater deflection efficiency using various needle insertion strategies and finalize the design of the clinically deployable needle and the associated controlling console with input from experts and potential consumers. This work will lead to further development activities, including thinner needle designs, an enhanced console design for implementation, and a closed-loop control system that enables real-time needle curvature and in situ tissue reaction force measurements. The IFOS team will also investigate steering protocols that would take advantage of axial rotation and other known passive control strategies, thereby adding bending degrees-of-freedom and dexterity to the needle system. These studies will culminate in a series of in vivo experiments, targeting liver/kidney biopsy and drug delivery procedures. Optimizing the needle for these specific clinical applications will drive the innovative IFOS product towards commercialization.

用于肿瘤学应用的光学传感驱动针 智能光纤系统公司 (IFOS) 2363 Calle del Mundo, 圣克拉拉, CA 95054-1008 www.ifos.com 项目摘要/摘要（最多 30 行） 在这个直接进入第二阶段的 SBIR 应用中，IFOS 和德克萨斯 A&M 大学建议开发和验证 主动转向、肌腱驱动、小口径针，用于精确成像辅助经皮穿刺 重点关注深层组织活检的程序。对临床医生的采访证实，转向 能力将极大地改善活检和药物输送的临床方法。用目前的方法，精确 在针对深层组织的手术中并不总是可以放置针头，因为进入的路径是 由于解剖学障碍和需要避开重要器官而受到限制。此外，由于针是 插入时，来自周围组织的力会导致针偏离计划的路径。这样的偏差 导致多次重新插入，增加患者不适和手术时间，并影响手术效果 微创手术的有效性。所提出的主动转向可以补偿偏转 在插入过程中遇到的问题，随着到达目标的路径延长，这种情况变得越来越重要。 主动转向概念基于线性伺服电机，通过连接的驱动针尖弯曲 肌腱纤维。空心镍钛针的设计特点允许药物输送和激光等应用 当另一根针插入宿主针芯内时发生消融。该设计还包含一个可拆卸的 核心附有光纤布拉格光栅，可感知阻碍的内部身体部位，从而减少对辅助的需求 手术过程中的 MR 成像。如果操作员想要查看这些信息，成像技术仍然是一种选择 由于针本身与 MRI 兼容，因此在手术过程中不会出现阻塞。在之前的工作中，弯曲率为 在模仿人类特性的模型中，每秒可重复实现超过 2 度的速度 前列腺组织，并且，我们实施了更细的针设计、直观的控制台设计概念以及 闭环控制系统，可实现实时针曲率和原位组织反作用力 测量。 最初的努力旨在通过不同的针插入方式展示更高的偏转效率 策略并最终确定临床可部署针头和相关控制台的设计 专家和潜在消费者的意见。这项工作将导致进一步的开发活动，包括 更细的针设计、增强的实施控制台设计以及闭环控制系统 实现实时针曲率和原位组织反作用力测量。 IFOS 团队还将研究利用轴向旋转和其他技术的转向协议。 已知的被动控制策略，从而增加针的弯曲自由度和灵活性 系统。这些研究最终将进行一系列体内实验，针对肝/肾活检和药物 交货程序。针对这些特定临床应用优化针头将推动创新的 IFOS 产品走向商业化。