Evaluating the Contribution of Synthetic Oxytocin Exposure in the Peripartum Period to Postpartum Depressive Symptoms in African American Women

项目总结 背景：合成催产素是一种围产期常用的药物，用于诱导 或增加分娩次数，防止产后出血。然而，它的长期后果， 尤其是与产后情绪有关的因素，在很大程度上是未知的。这一点尤其与 非裔美国母亲是产后抑郁症风险较高的人群。非洲 一般来说，美国女性有更高的变数导致缓慢分娩和 因此，从理论上讲，她们比高加索人有更大的风险接触合成催产素 母亲们。 目的：本研究的目的是首先描述该病的适应症和曝光率。 非裔美国女性对围产期合成催产素的反应。其次，我们将评估 围产期合成催产素暴露与抑郁症状的关系 非裔美国妇女在产后1周、3个月和6个月时，在控制 确定了潜在的混杂变量。 方法：我们将招募160名非洲裔美国女性的社会经济多样性队列来参加 这项研究。作为两项更大的纵向研究的一部分，参与者在10-14岁之间被招募 孕周，产后6个月随访。他们在家中接受了拜访，时间是 产后1周、3个月和6个月产后抑郁的评估 使用爱丁堡产后抑郁量表进行症状学评估。对于选定的子集，我们 将审查他们的分娩记录，以获得有关围产期合成催产素的详细数据 曝光。我们将把产前、产中和产后变量合并到一个新的数据集 描述合成催产素暴露情况，并评价其与产后抑郁症的关系。 影响：这项研究的结果将首次提供有关接触的信息 一种可能伴随着合成激素的比率增加了产后抑郁症的风险 这群非洲裔美国妇女，在出生和出生方面已经处于高度健康差距的风险中 婴儿结局。这些发现有可能在许多方面影响实践，包括 对修订剂量标准和改进风险评估和监测的思考 暴露于产后的妇女产后抑郁症。

PROJECT SUMMARY Background: Synthetic oxytocin is a medication commonly administered perinatally to induce or augment labor and prevent postpartum hemorrhage. However, its long term consequences, especially related to postpartum mood, are largely unknown. This is especially pertinent in African American mothers, a population at higher risk of postpartum depression. African American women have higher rates, in general, of variables that lead to slow labor and therefore are theoretically at greater risk of synthetic oxytocin exposure than Caucasian mothers. Purpose: The purpose of this study is firstly to characterize the indication for and exposure rate of African American women to perinatal synthetic oxytocin. Secondly, we will evaluate the association between exposure to perinatal synthetic oxytocin and depressive symptomatology in African American women at 1 week, 3 months, and 6 months postpartum, after controlling for identified potential confounding variables. Methods: We will enroll a socioeconomically diverse cohort of 160 African American women for this study. As part of two larger, longitudinal studies, participants were recruited between 10-14 weeks gestation and followed through 6 months postpartum. They were visited in their homes at 1 week, 3 months, and 6 months postpartum and assessed for postpartum depression symptomatology using the Edinburgh Postnatal Depression Scale. For the selected subset, we will review their labor and delivery records for detailed data on perinatal synthetic oxytocin exposure. We will combine prenatal, intrapartum, and postpartum variables into a novel dataset to describe synthetic oxytocin exposure and evaluate its relationship to postpartum depression. Implications: The results of this study will provide, for the first time, information on exposure rates to a synthetic hormone that may carry with it increased risk of postpartum depression in this population of African American women, already at high risk of health disparities in birth and infant outcomes. Findings have the potential to impact practice in many ways, including consideration of revising dosing standards and improved risk assessment and surveillance for postpartum depression in exposed women.