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A Neurocognitive Mechanism for Precision of Visual Working Memory Representations

视觉工作记忆表征精度的神经认知机制

基本信息

批准号：
9983158
负责人：
Weiwei Zhang
金额：
$ 28.22万
依托单位：
UNIVERSITY OF CALIFORNIA RIVERSIDE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-09 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9983158
关键词：
Affect Architecture Basic Science Behavioral Paradigm Brain Clinical Research Cognition Cognitive Complex Data Development Disease Exhibits Eye Eye Movements Fogs Functional Magnetic Resonance Imaging Future General Population Hippocampus (Brain)Human Impaired cognition Impairment Individual Individual Differences Intelligence Intervention Knowledge Life Literature Maintenance Measures Medial Memory Memory impairment Mental disorders Methods Mind Modeling Neurocognitive Noise Parietal Lobe Patient Self-Report Patients Pattern Perception Population Prefrontal Cortex Process Psyche structure Psychotic Disorders Research Research Design Role Running Saccades Schizophrenia Short-Term Memory Snakes Speed Stimulus Structure Symptoms System Temporal Lobe Tern Time Translating Translational Research Vertebral column Vision Visual base behavior measurement cognitive function cognitive neuroscience dentate gyrus design high risk language comprehension long term memory memory retention mental representation neuromechanism novel relating to nervous system vision science visual memory

项目摘要

The proposed research will explore the core cognitive and neural mechanisms for maintaining precise mental representations over a few seconds in working memory. Current research indicates that imprecise working memory is a key cognitive dysfunction in mental illness, which may be responsible for a common complaint of “brain fog” (e.g., blurry memory) from patients with mental disorders. Greater knowledge of the cognitive and neural mechanisms by which precise memory representations are maintained is pivotal not only to further our understanding of the overall architecture of the human mind in the healthy brain, but also to lay the groundwork for future clinical research on cognitive dysfunctions in mental disorders, including schizophrenia spectrum disorders. The research on working memory and its deficits in schizophrenia spectrum disorders in the past several decades has emphasized the quantitative aspect (capacity) of working memory and the corresponding neural mechanisms. However, only until recently has research begun to establish the theoretical and translational significance of the qualitative aspect (precision) of information maintained in working memory. The project will investigate the process and circuitry that support representing and retaining precise information in working memory using a combination of novel behavioral paradigms, individual differences, non-invasive brain stimulation, and functional magnetic resonance imaging. A novel cognitive and neural mechanism, namely pattern separation (Aim 2) in the hippocampal dentate gyrus subfield (Aim 3), is hypothesized to underlie mental clarity in working memory (Aim 1), based on the large literature on pattern separation and the emerging state model of memory that postulates a close relationship between short-term and long-term memories. The results will feed directly into our ongoing translational research (Aim 4) on foggy memory in schizophrenia spectrum disorders, including schizotypy (individuals at high risk for individuals at high-risk for psychosis symptoms). The present project will provide a clearer understanding of the functional limitations in working memory, which will establish the basic science backbone for future research designed to understand and treat cognitive dysfunction in schizophrenia spectrum disorders.

本研究将探讨维持的核心认知和神经机制