Core 1: Biospecimen and Pathology Core

核心 1：生物样本和病理学核心

基本信息

批准号：
9983044
负责人：
HARRY VINTERS
金额：
$ 17.8万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-11 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9983044
关键词：
Adherent Culture Animal Model Animals Archives Bioinformatics Biology Biometry Blood Brain Neoplasms Cancer Patient Cell Culture Techniques Cells Cerebrospinal Fluid Chromogenic in situ Hybridization Clinical Clinical Trials Clinical/Radiologic Collaborations Collection Consent Data Databases Development Diagnostic Ensure Family Formalin Freezing Glioblastoma Glioma Goals Grant Growth Health Insurance Portability and Accountability Act Histology Hospitals Human Immunohistochemistry Informatics Institutional Review Boards Joints Label Malignant neoplasm of brain Medical Genetics Microdissection Modeling Molecular Molecular Genetics Monitor Paraffin Pathologic Pathology Patients Pharmaceutical Preparations Primary Neoplasm Privacy Publications Recording of previous events Recurrent tumor Reporter Research Research Activity Research Personnel Research Project Grants Research Support Resources Sampling Services Slide Specimen System Temperature Therapeutic Therapeutic Studies Tissue Microarray Tissue Procurements Tissues Translational Research Tumor Burden Tumor Tissue Urine Work Xenograft Model Xenograft procedure biobank cancer cell career collaborative environment comparative cost data management drug discovery experience flexibility genetic information improved in vivo innovation neoplastic cell neuro-oncology neuroimaging neuropathology next generation novel novel therapeutic intervention pre-clinical preservation prognostic programs public repository sample collection success synergism translational diagnostics treatment response tumor tumor xenograft

项目摘要

Core 1: Biospecimen and Pathology Core (BiPC) SUMMARY/ABSTRACT The Biospecimen and Pathology Core (BiPC, Core 1), a biorepository and multi-faceted research resource led by experienced neuropathologists and cell biologists with ongoing active research expertise, will provide critical support for the translational prognostic, diagnostic, and therapeutic studies proposed in the UCLA SPORE in Brain Cancer. Working closely with the Biostatistics, Bioinformatics, and Data Management Core (BBD, Core 3), BiPC will maximize optimal biospecimen collection/storage and efficient disbursement of consented, clinically annotated, and molecularly characterized biospecimens. This Core will support all four SPORE projects with 24/7 tissue procurement, clinical and family history annotation, and molecular characterization of tissues, plus research support in gliomasphere/neurosphere cultures, tissue microarray, and patient-derived orthotopic xenografts (PDOX). The Biospecimen and Pathology Core Co-Directors and Investigators have a long collaboration history with each other and with all the SPORE Project Leaders, as shown in joint publications, grants, and consortia. In addition to an excellent program for the collection, processing, storage, and dissemination of important biospecimens in support of the proposed SPORE research projects, the BiPC agenda goes well beyond these core functions to the innovative development of new scientific approaches for the maximization of rare/sparse specimen collection and the development of new animal models for therapeutic drug discovery. As part of this core, brain cancer cells grown in animals will be specially adapted to have a fluorescent label so that growth or shrinkage of the tumor can be serially followed in vivo when experimental treatments are given to the animals. The BiPC will develop and provide these materials, resources, and information to SPORE investigators and others, both inside and outside of UCLA. An outstanding team of experienced, accomplished, determined, and productive investigators has been assembled for this Biospecimen and Pathology Core. It also has strong institutional commitment in an excellent collaborative environment, which will help to ensure the success of the overall goals of this SPORE proposal.

核心1：生物测量和病理核心（BIPC）摘要/摘要生物测量和病理学核心（BIPC，核心1），生物验证和多方面的研究资源LED 由经验丰富的神经病理学家和细胞生物学家拥有持续的积极研究专业知识，将提供关键支持UCLA孢子中提出的转化预后，诊断和治疗研究脑癌。与生物统计学，生物信息学和数据管理核心紧密合作（BBD，核心 3），BIPC将最大化最佳的生物测量收集/存储和有效的同意支出，临床注释，并具有分子表征的生物测量。该核心将支持所有四个孢子具有24/7组织采购，临床和家族史注释以及分子表征的项目组织，以及神经胶质细胞/神经圈培养物，组织微阵列和患者衍生的研究支持原位异种移植物（PDOX）。生物测量和病理学核心联合导演和研究人员具有彼此之间以及与所有孢子项目负责人之间的长期合作历史，如图所示出版物，赠款和财团。除了用于收集，处理，存储的出色程序外，并传播重要的生物测量以支持拟议的孢子研究项目，BIPC 议程远远超出了这些核心功能，这是新的科学方法的创新发展稀有/稀疏标本收集的最大化以及开发新动物模型治疗药物发现。作为该核心的一部分，在动物中生长的脑癌细胞将特别适应具有荧光标签，以便可以在体内串行肿瘤的生长或收缩对动物进行实验治疗。 BIPC将开发并提供这些材料，在UCLA内外，资源以及向孢子调查人员和其他人提供的信息。一个杰出的经验丰富，成就，决心和富有成效的调查员的团队已经为此生物植物和病理核心组装。它在出色的协作环境将有助于确保该孢子提案的总体目标成功。