Center for Translational Pediatric Research (CTPR)

阿肯色州儿童医院研究所(ACHRI)建议建立一个主题、多学科的研究中心，名为转化性儿科研究中心(CTPR)。ACHRI位于阿肯色州儿童医院，这是阿肯色州唯一的儿科医院；因此，为研究包括癌症在内的儿科疾病提供了独特的环境和临床人群。儿科学教授、发育表观遗传学、癌症、系统生物学和蛋白质组学领域的国际公认领导者艾伦·塔克特博士将领导该中心。他拥有丰富的管理经验，曾指导过多名初级教员，甚至获得了第一批R01。Tackett博士是阿肯色州人，NIH在他的整个职业生涯中一直在资助他，他参与NIH IDEA计划(通过Cobre和INBRE赠款)已有十多年。CTPR的科学主题是从系统生物学和机械观点研究儿科疾病是如何发展的，最终目的是确定疾病和发展的交叉点，这反过来又将产生治疗干预和新疗法开发的目标。CTPR的主题重点是全国范围内由Cobre支持的项目所独有的。CTPR的核心将是使用最先进的系统生物学方法来揭示和机械地探索儿科疾病的基础。CTPR将有一个行政核心、三个研究核心和四个研究项目。行政核心将指导中心的活动，建立和支持研究核心，监督试点项目计划，并通过全面的学院发展计划监督对项目负责人的指导。CTPR将支持蛋白质组学、基因组学和系统生物学生物信息学研究核心，这些核心对于中心的专题任务都是必不可少的。该中心最初将投资于四名初级教员，他们都将利用系统生物学工具研究与脑发育、慢性肾脏疾病、胃肠道发育、骨髓衰竭和癌症相关的各种儿科疾病。CTPR将真正成为一个主题、多学科的中心，汇集了儿科研究、发育生物学、癌症、成像、系统生物学、生物信息学、蛋白质组学和基因组学方面的专业知识。CTPR的长期目标是为一个专题、多学科的儿科研究中心提供长寿和可持续性，该中心利用尖端系统生物技术和最先进的转化研究来研究儿科疾病。CTPR第一阶段的短期目标是遵循中心组织和管理计划，以建立中心的基础，通过教师发展计划发展和指导初级调查人员，并将中心成员培养到必要的临界量，使集团在Cobre资助之外的外部支持方面具有竞争力。

The Arkansas Children's Hospital Research Institute (ACHRI) proposes to establish a thematic, multidisciplinary research center titled the Center for Translational Pediatric Research (CTPR). ACHRI is located at Arkansas Children's Hospital, which is the only pediatric hospital in Arkansas; thus, providing a unique environment and clinical population to study pediatric diseases including cancer. Dr. Alan Tackett, a Professor of Pediatrics and an internationally recognized leader in the field of developmental epigenetics, cancer, systems biology and proteomics, will direct the center. He has extensive administrative experience and has mentored multiple junior faculty to the point of receiving their first R01s. NIH has continually funded Dr. Tackett, a native Arkansan, for his entire career, and he has been involved with the NIH IDeA program (through COBRE and INBRE grants) for over a decade. The scientific theme of the CTPR is the study of how pediatric diseases develop from systems biology and mechanistic standpoints with the ultimate goal of identifying intersections of disease and development, which, in turn, will produce targets for therapeutic intervention and the development of new treatments. The thematic focus of the CTPR is unique to COBRE-supported programs nation-wide. The centerpiece of the CTPR will be the use of state-of-the-art systems biology approaches to uncover and mechanistically explore the basis of pediatric diseases. The CTPR will have an Administrative Core, three Research Cores and four Research Projects. The Administrative Core will direct the activities of the center, establish and support Research Cores, oversee a Pilot Project Program and oversee mentoring of Project Leaders through a comprehensive Faculty Development Plan. The CTPR will support Proteomic, Genomic and Systems Biology Bioinformatics Research Cores, which are each essential for the thematic mission of the center. The center will initially invest in four junior faculty members all of whom will utilize systems biology tools to study a variety of pediatric conditions related to brain development, chronic kidney disease, gastrointestinal tract development, bone marrow failure, and cancer. The CTPR will truly be a thematic, multi-disciplinary center bringing together expertise in pediatric research, developmental biology, cancer, imaging, systems biology, bioinformatics, proteomics and genomics. The long-term goal of the CTPR is to provide longevity and sustainability for a thematic, multidisciplinary pediatric research center that utilizes cutting-edge systems biology technologies and state-of-the-art translational research to study pediatric diseases. The short- term goal for Phase I of the CTPR is to follow a Center Organization and Management Plan to establish the foundation of the center, develop and mentor junior investigators with a Faculty Development Plan, and grow the center members to a critical mass necessary to position the group to be competitive for extramural support beyond COBRE-funding.