Center for Translational Pediatric Research

转化儿科研究中心

• 批准号: 10854464
• 负责人: Alan Tackett
• 金额: $ 95.57万
• 依托单位: ARKANSAS CHILDREN'S HOSPITAL RES INST
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-11 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10854464
• 关键词: 2019-nCoV; Acute respiratory infection; Address; Adenoviruses; Administrative Supplement; Age; Arkansas; Award; Bioinformatics; Black Populations; CLIA certified; COVID-19; COVID-19 pandemic; Centers of Research Excellence; Cessation of life; Characteristics; Child; Childhood; Classification; Clinical; Clinical Research; Clinical Treatment; Collaborations; Collection; Complex; Data; Data Correlations; Development; Disease; Disease Outbreaks; Electronic Health Record; Environment; Epidemiologist; Epidemiology; Ethnic Origin; Excision; Foundations; Funding; Genetic Variation; Genomics; Geographic Locations; Geography; Goals; Grant; Hispanic Populations; Hospitalization; Hypersensitivity; Immunology; Infection; Influenza; Institution; Intervention; Knowledge; Laboratories; Lead; Monitor; Nasopharynx; National Institute of Allergy and Infectious Disease; Native Americans; New Mexico; Oligonucleotides; Outcome; Parents; Patients; Pattern; Pediatric Hospitals; Pediatric Research; Phylogenetic Analysis; Population; Prevention; Protocols documentation; Publishing; Race; Recording of previous events; Research; Research Institute; Research Personnel; Respiratory Syncytial Virus Infections; Respiratory Tract Infections; Rhinovirus; Rhinovirus infection; Risk; Role; Rural Population; Sampling; Science; Scientist; Seasonal Variations; Seasons; Severities; Severity of illness; Shipping; Site; Social Distance; Specimen; Symptoms; Systems Biology; Technology; Testing; Time; Translational Research; Vaccination; Variant; Viral; Viral Genome; Viral Respiratory Tract Infection; Virulence; Virus; Virus Diseases; World Health Organization; asthma exacerbation; biobank; bioinformatics pipeline; clinically relevant; comorbidity; coronavirus disease; demographics; design; disease transmission; experience; genetic strain; genetic variant; genomic variation; health care availability; human genomics; improved; innovation; multidisciplinary; next generation; next generation sequencing; novel; pathogen; prognostic; prospective; regional difference; respiratory; respiratory virus; transmission process; viral genomics; virus genetics

Project Summary Parent award. The parent award for this supplement is associated with the Arkansas Children's Research Institute (ACRI) Center for Translational Pediatric Research (CTPR: P20GM121293-05S1). The CTPR aims to build an innovative, multi-disciplinary pediatric research center that utilizes cutting-edge systems biology technologies and state-of-the-art translational research to study pediatric diseases. The COBRE Administrative Supplement NOSI supports the development of team science projects that bring together… investigators from IDeA states with different perspectives and expertise to address complex, clinical and/or translational research questions with complementary approaches. These goals are in lockstep, and this proposal utilizes team science approaches from investigators with a history of successful collaborations from two IDeA states. The current proposal is directly in line with the goals of the CTPR and is headed by one current and two former COBRE-funded investigators from two IDeA states. The overall objective of the Pediatric Acute Respiratory Infection Study (PARIS) is to conduct a comprehensive genomic assessment of current circulating respiratory viruses and compare those to viruses collected since 2015 to elucidate the clinical impact of viral genetic diversity and the geographic and temporal distribution of respiratory virus strains and how respiratory viruses change throughout the seasons and over multiple years. Research question. Respiratory infections cause approximately 2 million global deaths each year. As was seen during the COVID-19 pandemic, different genetic strains of the same virus may have varying levels of virulence and clinical manifestations. Differentiating and determining these factors during clinical presentations is crucial for all respiratory viruses. This supplement aims to differentiate and determine the clinical impact of viral genetic diversity, distribution, and seasonal variations of respiratory viruses, expanding our knowledge beyond SARS- CoV-2. By sequencing and comparing historical and current viral samples, we will provide actionable information on transmission patterns, genomics, phylogenetics, and epidemiology of respiratory viruses to clinicians. Further, we will compare Electronic Health Records data from Arkansas and New Mexico to classify the severity of clinical outcomes using the World Health Organization's Ordinal Scale for Clinical Improvement and based on the isolated viral variant. Team science approach. We represent a collaboration between clinicians, genomic scientists, and epidemiologists. Dr. Kennedy is an Allergy and Immunology clinician at Arkansas Children's Hospital and ACRI, who has extensively studied the role of respiratory infections causing asthma exacerbations. Dr. Dinwiddie is an expert in respiratory viruses and human genomics and has over fifteen years of experience designing, developing, and implementing next-generation sequencing protocols, including in a CAP/CLIA-approved environment. Dr. Domman is a microbiologist, bioinformatician, and genomic epidemiologist who has published extensively on the use of sequence data to understand the transmission of infectious diseases. Together, we each bring expertise that, when combined in the form of team science, enables a robust and extensive study to investigate the role of genomic and temporal variation of respiratory viruses in the clinical outcomes of pediatric respiratory infections.

项目摘要 家长奖。这一补充的家长奖与阿肯色州儿童研究有关 研究所（阿克里）转化儿科研究中心（CTPR：P20 GM 121293 - 05 S1）。CTPR旨在 建立一个创新的，多学科的儿科研究中心，利用尖端的系统生物学 技术和最先进的转化研究，以研究儿科疾病。COBRE行政 NOSI支持团队科学项目的发展，这些项目汇集了...... 从不同的角度和专业知识来解决复杂的，临床和/或翻译 用互补的方法研究问题。这些目标是步调一致的，本提案利用团队 科学的方法，从研究人员的成功合作的历史，从两个IDEA国家。 目前的建议与CTPR的目标直接一致，由一名现任和两名前任领导。 来自两个州的COBRE-funded调查人员。儿科急性呼吸道疾病的总体目标 感染研究（巴黎）将对当前循环呼吸道感染进行全面的基因组评估。 病毒，并将其与2015年以来收集的病毒进行比较，以阐明病毒遗传多样性的临床影响 以及呼吸道病毒株的地理和时间分布以及呼吸道病毒如何变化 在整个季节和多年里。 研究问题。呼吸道感染每年在全球造成约200万人死亡。正如所见， 在COVID-19大流行期间，同一病毒的不同基因株可能具有不同的毒力水平 和临床表现。在临床表现中区分和确定这些因素至关重要 所有呼吸道病毒。本补充旨在区分和确定病毒遗传的临床影响， 呼吸道病毒的多样性、分布和季节性变化，扩展了我们对SARS以外的知识- 二型冠状病毒通过对历史和当前病毒样本进行测序和比较，我们将提供可操作的信息 呼吸道病毒的传播模式、基因组学、遗传学和流行病学。此外，本发明还 我们将比较阿肯色州和新墨西哥州的电子健康记录数据， 结果使用世界卫生组织的临床改善顺序量表，并基于 分离的病毒变体。 团队科学方法。我们代表了临床医生、基因组科学家和 流行病学家肯尼迪博士是阿肯色州儿童医院和阿克里的过敏和免疫学临床医生， 世卫组织广泛研究了呼吸道感染引起哮喘恶化的作用。丁威迪博士是一位 呼吸道病毒和人类基因组学专家，拥有超过十五年的设计经验， 开发和实施下一代测序方案，包括CAP/CLIA批准的 环境Domman博士是微生物学家、生物信息学家和基因组流行病学家， 广泛地利用序列数据来了解传染病的传播。一起我们 每个人都带来了专业知识，当以团队科学的形式结合在一起时，可以进行强大而广泛的研究， 研究呼吸道病毒的基因组和时间变异在儿科临床结局中的作用 呼吸道感染

项目成果

Identification of natural compounds tubercidin and lycorine HCl against small-cell lung cancer and BCAT1 as a therapeutic target.

• DOI: 10.1111/jcmm.17246
• 发表时间: 2022-05
• 期刊: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
• 影响因子: 5.3
• 作者: Chen, Jungang;Barrett, Lindsey;Lin, Zhen;Kendrick, Samantha;Mu, Shengyu;Dai, Lu;Qin, Zhiqiang
• 通讯作者: Qin, Zhiqiang

Role of bacterial infections in extracellular vesicles release and impact on immune response.

• DOI: 10.1016/j.bj.2020.05.006
• 发表时间: 2021-04
• 期刊: Biomedical journal
• 影响因子: 5.5
• 作者: Spencer N;Yeruva L
• 通讯作者: Yeruva L

Conditional mutagenesis in vivo reveals cell type- and infection stage-specific requirements for LANA in chronic MHV68 infection.

• DOI: 10.1371/journal.ppat.1006865
• 发表时间: 2018-01
• 期刊: PLoS pathogens
• 影响因子: 6.7
• 作者: Salinas E;Gupta A;Sifford JM;Oldenburg DG;White DW;Forrest JC
• 通讯作者: Forrest JC

Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer.

• DOI: 10.1039/d1mo00117e
• 发表时间: 2021-10-11
• 期刊: Molecular omics
• 影响因子: 2.9
• 作者: Chappell K;Manna K;Washam CL;Graw S;Alkam D;Thompson MD;Zafar MK;Hazeslip L;Randolph C;Gies A;Bird JT;Byrd AK;Miah S;Byrum SD
• 通讯作者: Byrum SD

Deficiency of N-glycanase 1 perturbs neurogenesis and cerebral development modeled by human organoids.

• DOI: 10.1038/s41419-022-04693-0
• 发表时间: 2022-03-24
• 期刊: Cell death & disease
• 影响因子: 9
• 作者: Lin VJT;Hu J;Zolekar A;Salick MR;Mittal P;Bird JT;Hoffmann P;Kaykas A;Byrum SD;Wang YC
• 通讯作者: Wang YC