Core I: 90+ Cohort

核心一：90 队列

• 批准号: 10188389
• 负责人: Maria Corrada
• 金额: $ 19.27万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10188389
• 关键词: Age-Years; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Asian Americans; Autopsy; Biological Markers; Brain; Brain imaging; California; Clinical; Collaborations; Collection; Complement; Consent; Data; Data Set; Dedications; Dementia; Ecosystem; Education; Enrollment; Ensure; Environment; Ethnic Origin; Fatigue; Genetic; Goals; Hispanics; Impaired cognition; Individual; Investigation; Kava; Longevity; Longitudinal Studies; Magnetic Resonance Imaging; Participant; Pathologic; Population; Populations at Risk; Procedures; Research; Research Personnel; Resolution; Resource Sharing; Resources; Risk; Role; Special Population; Testing; Training and Education; Universities; Visual impairment; Work; career; clinical biomarkers; cohort; data management; data resource; education research; hearing impairment; imaging genetics; imaging study; improved; innovation; mortality; multimodal data; neuroimaging; neuropathology; next generation; novel; outreach; patient engagement; recruit; resilience

Core I: The 90+ Core Project Summary/Abstract The overall objective of the 90+ Core is to expand the integration of The 90+ Study's (R01AG20055, MPI: C. Kawas, M. Corrada) data and resources into the research environment of the UCI ADRC. The 90+ Study is an ongoing longitudinal study of the oldest-old at UCI that has been operating for 16 years and has acquired an unparalleled amount of high-quality data from well-characterized participants including clinical, imaging, genetic, and neuropathological data. The study has become an invaluable resource for research on the oldest- old, people 90 years of age and older. The oldest-old represent the fastest growing segment of the population and have the highest rates of dementia. Yet, oldest-old individuals are severely understudied as they are often excluded from research. The 90+ Core includes participants from The 90+ Study who have agreed to brain autopsy or brain imaging. The 90+ Core will act as a centralized resource to improve the capacity for much- needed research in the oldest-old and will enable effective management and coordination of resources and collaboration between The 90+ Study and the ADRD research environment within and beyond the UCI ADRC. The efficient sharing and distribution of data and resources will encourage research in the oldest-old with the ultimate goal of understanding dementia and its pathological underpinnings, cognitive impairment, resilience, and the role of biomarkers in our oldest citizens. The 90+ Core will coordinate brain donation and post-mortem brain MRI from participants who have agreed to autopsy, will increase recruitment of individuals from underrepresented ethnicities into our autopsy and imaging studies, and will identify participants relevant to other ADRC investigators. In addition, The 90+ Core will also assemble and maintain an easily accessible, de-identified, interlinked data resource that includes clinical, biomarker, genetics, and neuropathology data to facilitate resource sharing and will develop strategies for handling analytic problems particularly relevant to research in the oldest-old. Finally, with particular expertise for conducting studies of the oldest-old, The 90+ Core will contribute to the education and training of the next generation of ADRD clinicians and researchers. In close collaboration with other Cores and the Research Education Component, The 90+ Core will provide opportunities to connect and collaborate and will serve as a centralized resource to facilitate and encourage novel research in the oldest-old across the UCI ADRC and larger AD ecosystem.

核心 I：90+ 核心 项目概要/摘要 90+ 核心的总体目标是扩展 90+ 研究（R01AG20055，MPI：C. Kawas, M. Corrada）将数据和资源引入 UCI ADRC 的研究环境。 90+ 研究是一项 正在进行的对 UCI 最年长老人的纵向研究，该研究已经运营了 16 年，并获得了 来自特征明确的参与者的无与伦比的高质量数据，包括临床、影像、 遗传和神经病理学数据。该研究已成为最古老的研究的宝贵资源。 老，90岁以上的人。最年长的老年人代表了人口增长最快的部分 并且痴呆症发病率最高。然而，最年长的个体却被严重低估，因为他们经常 被排除在研究之外。 90+ 核心包括 90+ 研究中同意大脑的参与者 尸检或脑成像。 90+ 核心将充当集中资源，以提高更多能力- 需要对最年长的老年人进行研究，这将有助于有效管理和协调资源和 90+ 研究与 UCI ADRC 内外的 ADRD 研究环境之间的合作。 数据和资源的有效共享和分配将鼓励老年人的研究 最终目标是了解痴呆症及其病理基础、认知障碍、复原力、 以及生物标志物在我们最古老的公民中的作用。 90+ 核心将协调同意参加者的脑部捐赠和尸检脑部 MRI 尸检，将增加招募来自代表性不足的种族的个人参与我们的尸检， 影像研究，并将确定与其他 ADRC 研究人员相关的参与者。此外，90+核心 还将组装和维护一个易于访问、去识别化、相互链接的数据资源，其中包括 临床、生物标志物、遗传学和神经病理学数据，以促进资源共享并制定策略 用于处理特别与老年人研究相关的分析问题。最后，以特别 90岁以上核心人员拥有对最年长老人进行研究的专业知识，将有助于教育和培训 下一代 ADRD 临床医生和研究人员。 通过与其他核心和研究教育部分的密切合作，90+ 核心将提供 联系和协作的机会，并将作为集中资源来促进和鼓励 在 UCI ADRC 和更大的 AD 生态系统中最古老的研究中进行的新颖研究。