Core I: 90+ Cohort

核心一：90 队列

• 批准号: 10582654
• 负责人: Maria Corrada
• 金额: $ 18.67万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10582654
• 关键词: Age Years; Agreement; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Asian Americans; Autopsy; Biological Markers; Brain; Brain imaging; California; Clinical; Collaborations; Collection; Complement; Consent; Data; Data Set; Dedications; Dementia; Ecosystem; Education; Enrollment; Ensure; Environment; Ethnic Origin; Exclusion; Fatigue; Genetic; Goals; Hispanic Populations; Image; Impaired cognition; Individual; Investigation; Longevity; Longitudinal Studies; Participant; Pathologic; Persons; Population; Populations at Risk; Procedures; Research; Research Personnel; Resolution; Resource Sharing; Resources; Risk; Role; Special Population; Testing; Training and Education; Universities; Visual impairment; Work; brain magnetic resonance imaging; career; cohort; data management; data resource; education research; hearing impairment; imaging study; improved; innovation; mortality; multimodal data; neuroimaging; neuropathology; next generation; novel; outreach; patient engagement; recruit; resilience

Core I: The 90+ Core Project Summary/Abstract The overall objective of the 90+ Core is to expand the integration of The 90+ Study's (R01AG20055, MPI: C. Kawas, M. Corrada) data and resources into the research environment of the UCI ADRC. The 90+ Study is an ongoing longitudinal study of the oldest-old at UCI that has been operating for 16 years and has acquired an unparalleled amount of high-quality data from well-characterized participants including clinical, imaging, genetic, and neuropathological data. The study has become an invaluable resource for research on the oldest- old, people 90 years of age and older. The oldest-old represent the fastest growing segment of the population and have the highest rates of dementia. Yet, oldest-old individuals are severely understudied as they are often excluded from research. The 90+ Core includes participants from The 90+ Study who have agreed to brain autopsy or brain imaging. The 90+ Core will act as a centralized resource to improve the capacity for much- needed research in the oldest-old and will enable effective management and coordination of resources and collaboration between The 90+ Study and the ADRD research environment within and beyond the UCI ADRC. The efficient sharing and distribution of data and resources will encourage research in the oldest-old with the ultimate goal of understanding dementia and its pathological underpinnings, cognitive impairment, resilience, and the role of biomarkers in our oldest citizens. The 90+ Core will coordinate brain donation and post-mortem brain MRI from participants who have agreed to autopsy, will increase recruitment of individuals from underrepresented ethnicities into our autopsy and imaging studies, and will identify participants relevant to other ADRC investigators. In addition, The 90+ Core will also assemble and maintain an easily accessible, de-identified, interlinked data resource that includes clinical, biomarker, genetics, and neuropathology data to facilitate resource sharing and will develop strategies for handling analytic problems particularly relevant to research in the oldest-old. Finally, with particular expertise for conducting studies of the oldest-old, The 90+ Core will contribute to the education and training of the next generation of ADRD clinicians and researchers. In close collaboration with other Cores and the Research Education Component, The 90+ Core will provide opportunities to connect and collaborate and will serve as a centralized resource to facilitate and encourage novel research in the oldest-old across the UCI ADRC and larger AD ecosystem.

核心一：90+核心 项目总结/摘要 90+核心的总体目标是扩大90+研究（R01AG20055，MPI：C. Kawas，M. Corrada）的数据和资源到UCI ADRC的研究环境中。90+研究是一项 正在进行的对UCI最年长者的纵向研究，该研究已经开展了16年， 来自特征良好的参与者的无与伦比的高质量数据量，包括临床，成像， 遗传学和神经病理学数据。这项研究已成为研究最古老的- 90岁以上的老人。最年长的人是人口中增长最快的部分 痴呆症的发病率最高然而，年龄最大的人往往被严重低估， 排除在研究之外。90+核心包括来自90+研究的参与者，他们同意使用大脑 尸检或脑部成像90+核心将作为一个集中的资源，以提高能力， 需要在最古老的研究，并将使有效的管理和协调资源， 90+研究与UCI ADRC内外的ADRD研究环境之间的合作。 数据和资源的有效共享和分配将鼓励对最老的老年人进行研究， 最终目标是了解痴呆症及其病理基础，认知障碍，恢复力， 以及生物标志物在老年人中的作用。 90 + Core将协调同意参与者的大脑捐赠和死后大脑MRI， 尸检，将增加从代表性不足的种族招募个人进入我们的尸检， 影像学研究，并将确定参与者相关的其他ADRC调查。90+核心 还将收集和维护一个易于访问、去识别、相互关联的数据资源，包括 临床、生物标志物、遗传学和神经病理学数据，以促进资源共享，并将制定战略 处理分析问题，特别是与最古老的研究有关的问题。最后，特别是 专业知识进行研究的最古老的老人，90+核心将有助于教育和培训， 下一代ADRD临床医生和研究人员。 在与其他核心和研究教育组件的密切合作，90+核心将提供 联系和协作的机会，并将作为集中资源来促进和鼓励 在UCI ADRC和更大的AD生态系统中，对最古老的老年人进行了新的研究。