Non-invasive biometric screening for cerebrovascular disorders in persons with Down syndrome.
唐氏综合症患者脑血管疾病的无创生物识别筛查。
基本信息
- 批准号:10353415
- 负责人:
- 金额:$ 18.53万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-02-17 至 2026-01-31
- 项目状态:未结题
- 来源:
- 关键词:AccountingActive LearningAddressAgeArchitectureAreaBioinformaticsBiological MarkersBiometryBlood PressureBlood VesselsCCL2 geneCaringCerebrovascular CirculationCerebrovascular DisordersChildChildhoodChronicClinical TrialsClinical Trials DesignCommunicationCompetenceDataData AnalysesDepositionDevelopmentDevelopment PlansDiagnosisDiseaseDisease PathwayDown SyndromeEarly DiagnosisEarly InterventionEarly identificationEdemaEducational workshopEnsureEpidemiologyEtiologyFunctional disorderFundingGenetic DiseasesGliosisGoalsGoldGranulocyte-Macrophage Colony-Stimulating FactorHead and neck structureHealthHealthcareHeightHemosiderinHomeHypertensionHypotensionImageImmuneIncidenceIndividualInfantInflammationInflammatoryInstitutionInterferon Type IIInterleukin-6InvestigationK-Series Research Career ProgramsKnowledgeLearningLinkLocationLos AngelesMagnetic Resonance ImagingMeasurementMeasuresMentorsMentorshipMetabolic dysfunctionModalityMorbidity - disease rateMoyamoya DiseaseNeckNeurocognitiveNeurologicNeurologic SymptomsPGF genePatientsPersonsPhysiciansPositioning AttributePrevalencePreventionProgram DevelopmentProspective StudiesPublishingRegression AnalysisReproducibilityResearchResearch PersonnelRetrospective StudiesRiskRoleScienceScientistScreening procedureSecondary toStandardizationStenosisStrokeTNF geneTechniquesTherapeutic InterventionTimeTrainingTranscranial Doppler UltrasonographyUltrasonographyUnited StatesUnited States National Institutes of HealthVascular Cell Adhesion Molecule-1Vascular DiseasesVascular Endothelial Growth FactorsWeightWorkagedbasebiomedical informaticsblood pressure elevationblood pressure reductionbrain magnetic resonance imagingcareercareer developmentcerebrovascularchronic inflammatory diseasecohortcostdesignearly screeningexperiencefeasibility researchimprovedinterleukin-22mortalityneurocognitive testneurodevelopmentneuroimagingpopulation basedpredictive markerpreventprospectiveresponsescreeningsexskillssystemic inflammatory responsetoolvascular inflammation
项目摘要
ABSTRACT:
Dr. Jonathan Santoro is a clinician-scientist focused on exploring the interface between vascular disease,
cerebrovascular disease (CeVD) and inflammation in persons with Down syndrome (DS). This five-year
mentored career development award will provide him with advanced training and skills in population-based
data analysis, biostatistics, neuroimaging, and clinical trials development to ensure a successful transition to
an independent research career. The outlined proposal builds on previously published work by Dr. Santoro and
leverages a mentorship team of experts in DS, neurodevelopment, vascular disease, and cerebrovascular-
inflammatory disorders in persons with DS at his home institution and other large academic DS centers.
Research Context: Persons with DS have an increased risk of early CeVD, specifically moyamoya syndrome,
and the initial presentation is often irreversible neurologic insult secondary to cerebrovascular accident. For
persons with DS, there exists no validated means of assessing risk for CeVD. This K23 career development
builds on previous work by Dr. Santoro who identified non-invasive ways to screen for CeVD in children with
DS. This study will prospectively asses blood pressure (BP) in persons with DS and subsequently use this to
predict pre-symptomatic CeVD (Aim 1). Next, this study will compare gold standard CeVD neuroimaging
studies to various non-invasive, low-cost, biometric tools such as repeated BP measurements, transcranial
Doppler ultrasound and neurocognitive testing to assess internal and predictive validity of these measures in
the prediction of CeVD (Aim 2). As persons with DS are established to have immune dysregulation and
systemic inflammatory profiles, we will also explore the role of systemic and vascular inflammatory biomarkers
in the development of CeVD with the goal of identifying contributory inflammatory cascades that could be
targeted with therapeutic interventions geared towards preventing CeVD in subsequent studies (Aim 3).
Career Development Plan: Dr. Santoro will complete coursework in healthcare and science communication,
data analysis, epidemiology, clinical trial design and biomedical informatics. This plan also will strengthen his
competence in both bioinformatics and neuroimaging and be supplemented by institutional workshops and
seminars. This experiential learning is designed to promote knowledge and skillset development needed to
both execute his research and ensure that skills are developed for his transition to an independent researcher.
Dr. Santoro’s career development goals will be supported through close mentorship by an experienced and
committed interdisciplinary team and a combination of didactic, experiential, and team-based learning. This
proposal and subsequent R01 proposals seek to improve the neurologic care of young persons with DS.
文摘:
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jonathan Douglas Santoro其他文献
Pediatric Bickerstaff brainstem encephalitis: a systematic review of literature and case series
- DOI:
10.1007/s00415-017-8684-8 - 发表时间:
2017-11-24 - 期刊:
- 影响因子:4.600
- 作者:
Jonathan Douglas Santoro;Daniel V. Lazzareschi;Cynthia Jane Campen;Keith P. Van Haren - 通讯作者:
Keith P. Van Haren
Jonathan Douglas Santoro的其他文献
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{{ truncateString('Jonathan Douglas Santoro', 18)}}的其他基金
Non-invasive biometric screening for cerebrovascular disorders in persons with Down syndrome.
唐氏综合症患者脑血管疾病的无创生物识别筛查。
- 批准号:
10816240 - 财政年份:2023
- 资助金额:
$ 18.53万 - 项目类别:
Non-invasive biometric screening for cerebrovascular disorders in persons with Down syndrome.
唐氏综合症患者脑血管疾病的无创生物识别筛查。
- 批准号:
10580713 - 财政年份:2021
- 资助金额:
$ 18.53万 - 项目类别:
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